SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 9 LEU A 130
LEU A 114
VAL A  94
LEU A 101
PHE A 119
 None
 1.25A 1tbfA-2o6rA:
undetectable		 1tbfA-2o6rA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 8 LEU A  66
LYS A 110
ASN A 109
LEU A 106
 None
 1.15A 2xn3A-2o6rA:
undetectable
2xn3B-2o6rA:
undetectable		 2xn3A-2o6rA:
20.00
2xn3B-2o6rA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 5 SER A 162
ASP A 140
ASP A 144
ILE A 142
 None
 1.25A 3uj7B-2o6rA:
undetectable		 3uj7B-2o6rA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 LEU A  82
LEU A 106
LEU A 130
ALA A 129
LEU A 101
 None
 1.11A 4ltwA-2o6rA:
undetectable		 4ltwA-2o6rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 VAL A 138
LEU A 135
LEU A 173
LEU A 154
ALA A 184
 None
 1.05A 4p65F-2o6rA:
undetectable
4p65H-2o6rA:
undetectable
4p65K-2o6rA:
undetectable
4p65L-2o6rA:
undetectable		 4p65F-2o6rA:
8.47
4p65H-2o6rA:
8.47
4p65K-2o6rA:
8.61
4p65L-2o6rA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 7 SER A  83
TYR A 105
ARG A  55
GLU A  59
 None
 1.43A 4xzkA-2o6rA:
undetectable		 4xzkA-2o6rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 11 LEU A 173
LEU A 106
LEU A 125
LEU A 149
LEU A 104
 None
 0.96A 4zowA-2o6rA:
undetectable		 4zowA-2o6rA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 8 LEU A  80
ILE A  35
PHE A  71
LEU A  63
 None
 0.88A 5eseA-2o6rA:
undetectable		 5eseA-2o6rA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		6 / 12 LEU A  63
VAL A  45
ALA A 129
PHE A  95
LEU A  77
VAL A  94
 None
 1.47A 5tudA-2o6rA:
undetectable		 5tudA-2o6rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2o6r VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 8 LEU A 111
GLN A 134
VAL A 138
LEU A 114
 None
 0.78A 6czmD-2o6rA:
undetectable
6czmF-2o6rA:
undetectable		 6czmD-2o6rA:
20.96
6czmF-2o6rA:
20.96