SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 8 ASP A  57
GLU A 127
SER A 107
THR A 108
 None
 0.77A 1m4iA-2o6sA:
undetectable		 1m4iA-2o6sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 7 TYR A 155
TRP A 177
TYR A 175
GLY A 202
 None
 1.31A 1mxgA-2o6sA:
undetectable		 1mxgA-2o6sA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 LEU A 104
LEU A  80
LEU A  56
LEU A  90
LEU A  87
 None
 1.06A 1sqnB-2o6sA:
undetectable		 1sqnB-2o6sA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 LEU A 128
LEU A 104
LEU A  80
LEU A 114
LEU A 111
 None
 1.07A 1sqnB-2o6sA:
undetectable		 1sqnB-2o6sA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 LEU A 152
LEU A 128
LEU A 104
LEU A 138
LEU A 135
 None
 1.03A 1sqnB-2o6sA:
undetectable		 1sqnB-2o6sA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 9 LEU A 130
LEU A 114
VAL A  94
LEU A 101
PHE A 119
 None
 1.26A 1tbfA-2o6sA:
undetectable		 1tbfA-2o6sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 8 LEU A  98
LEU A  58
VAL A  45
VAL A  94
 None
 1.03A 2bdmA-2o6sA:
undetectable		 2bdmA-2o6sA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 8 LEU A 193
LEU A 152
VAL A 142
GLY A 141
 None
 0.98A 2po5B-2o6sA:
undetectable		 2po5B-2o6sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 7 ILE A 197
TYR A 192
PHE A 167
ASP A 168
 None
 1.14A 2qebB-2o6sA:
undetectable		 2qebB-2o6sA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 LEU A 104
LEU A 122
PRO A  50
THR A  34
THR A  78
 None
 1.13A 3dcjA-2o6sA:
undetectable
3dcjB-2o6sA:
undetectable		 3dcjA-2o6sA:
20.34
3dcjB-2o6sA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 5 LYS A 223
PRO A 224
SER A 215
SER A 194
 None
 1.42A 3ijxH-2o6sA:
undetectable		 3ijxH-2o6sA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		6 / 12 LEU A  63
VAL A  45
ALA A 129
PHE A  95
LEU A  77
VAL A  94
 None
 1.50A 4ib4A-2o6sA:
undetectable		 4ib4A-2o6sA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 6 ARG A 191
ASP A 168
GLY A 165
ASP A 164
 None
 1.06A 5hp1A-2o6sA:
undetectable		 5hp1A-2o6sA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMW_A_PNNA305_0
(BETA-LACTAMASE
TOHO-1)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		4 / 4 ASN A  92
PRO A 115
ASN A 116
ASP A 120
 None
 1.25A 5kmwA-2o6sA:
undetectable		 5kmwA-2o6sA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 THR A  33
GLN A  52
ARG A  42
PRO A  46
GLY A  48
 None
 1.14A 5m50B-2o6sA:
undetectable		 5m50B-2o6sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2o6s VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri) 		5 / 12 LEU A  63
VAL A  45
PHE A  95
LEU A  77
VAL A  94
 None
 1.07A 5tudA-2o6sA:
undetectable		 5tudA-2o6sA:
17.53