SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A 137
ILE A 151
GLY A 149
ALA A 150
LEU A 127
 None
 1.04A 1cqeA-2o6wA:
undetectable		 1cqeA-2o6wA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A 137
ILE A 151
GLY A 149
ALA A 150
LEU A 127
 None
 1.04A 1cqeB-2o6wA:
undetectable		 1cqeB-2o6wA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		4 / 8 ALA A 145
LEU A 162
ALA A 140
THR A 160
 None
 0.89A 1ie4B-2o6wA:
undetectable
1ie4D-2o6wA:
undetectable		 1ie4B-2o6wA:
16.77
1ie4D-2o6wA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A 132
VAL A 155
LEU A 157
ILE A 165
ALA A 145
 None
 1.18A 2gj5A-2o6wA:
undetectable		 2gj5A-2o6wA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A 107
GLY A 129
LEU A 147
LEU A 112
LEU A  92
 None
 1.10A 2zbpA-2o6wA:
undetectable		 2zbpA-2o6wA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A 107
GLY A 129
LEU A 147
LEU A 112
LEU A  92
 None
 1.16A 3cjtG-2o6wA:
undetectable		 3cjtG-2o6wA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A 137
ILE A 151
GLY A 149
ALA A 150
LEU A 127
 None
 1.07A 3n8xB-2o6wA:
undetectable		 3n8xB-2o6wA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 THR A 160
LEU A 157
ASN A 156
LEU A 132
LEU A 142
 None
 1.32A 3ndvA-2o6wA:
undetectable
3ndvB-2o6wA:
undetectable		 3ndvA-2o6wA:
18.70
3ndvB-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 THR A 160
LEU A 157
ASN A 156
LEU A 162
LEU A 142
 None
 1.38A 3ndvA-2o6wA:
undetectable
3ndvB-2o6wA:
undetectable		 3ndvA-2o6wA:
18.70
3ndvB-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		6 / 11 LEU A 112
LEU A  92
THR A 110
LEU A 107
ASN A  86
LEU A  82
 None
 1.49A 3ndvA-2o6wA:
undetectable
3ndvB-2o6wA:
undetectable		 3ndvA-2o6wA:
18.70
3ndvB-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 LEU A 142
THR A 160
LEU A 157
ASN A 156
LEU A 132
 None
 1.28A 3ndvA-2o6wA:
undetectable
3ndvB-2o6wA:
undetectable		 3ndvA-2o6wA:
18.70
3ndvB-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 LEU A 162
THR A 160
LEU A 157
ASN A 156
LEU A 132
 None
 1.39A 3ndvA-2o6wA:
undetectable
3ndvB-2o6wA:
undetectable		 3ndvA-2o6wA:
18.70
3ndvB-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 THR A 160
LEU A 157
ASN A 156
LEU A 132
LEU A 142
 None
 1.30A 3ndvC-2o6wA:
undetectable
3ndvD-2o6wA:
undetectable		 3ndvC-2o6wA:
18.70
3ndvD-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 THR A 160
LEU A 157
ASN A 156
LEU A 132
LEU A 162
 None
 1.40A 3ndvC-2o6wA:
undetectable
3ndvD-2o6wA:
undetectable		 3ndvC-2o6wA:
18.70
3ndvD-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 LEU A 142
THR A 160
LEU A 157
ASN A 156
LEU A 132
 None
 1.33A 3ndvC-2o6wA:
undetectable
3ndvD-2o6wA:
undetectable		 3ndvC-2o6wA:
18.70
3ndvD-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 11 LEU A 162
LEU A 142
THR A 160
LEU A 157
ASN A 156
 None
 1.38A 3ndvC-2o6wA:
undetectable
3ndvD-2o6wA:
undetectable		 3ndvC-2o6wA:
18.70
3ndvD-2o6wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		4 / 6 ALA A 125
ASN A 126
LEU A 107
VAL A 108
 None
 0.99A 4g24A-2o6wA:
undetectable		 4g24A-2o6wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		4 / 6 ALA A 135
ASN A 136
LEU A 117
GLU A 158
 None
 1.08A 4g24A-2o6wA:
undetectable		 4g24A-2o6wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 ARG A  59
ALA A  77
ASN A  53
GLY A  55
LEU A  56
 None
 1.06A 4oaeA-2o6wA:
undetectable		 4oaeA-2o6wA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		4 / 8 ALA A 130
ASN A 126
LEU A 122
ALA A  85
 None
 0.69A 4wboB-2o6wA:
undetectable		 4wboB-2o6wA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		4 / 8 ALA A 150
ASN A 146
LEU A 142
ALA A 105
 None
 0.77A 4wboB-2o6wA:
undetectable		 4wboB-2o6wA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 10 LEU A 117
LEU A 137
ASN A 131
SER A 113
ALA A 125
 None
 1.03A 4xj7C-2o6wA:
undetectable
4xj7D-2o6wA:
undetectable		 4xj7C-2o6wA:
21.43
4xj7D-2o6wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 8 LEU A 137
LEU A 142
LEU A 147
ALA A 150
ALA A 135
 None
 1.07A 4z90A-2o6wA:
undetectable
4z90B-2o6wA:
undetectable
4z90C-2o6wA:
undetectable
4z90D-2o6wA:
undetectable
4z90E-2o6wA:
undetectable		 4z90A-2o6wA:
20.82
4z90B-2o6wA:
20.82
4z90C-2o6wA:
20.82
4z90D-2o6wA:
20.82
4z90E-2o6wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 LEU A  97
ILE A 165
THR A 110
ALA A 130
LEU A 147
 None
 1.22A 5ienA-2o6wA:
undetectable		 5ienA-2o6wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		6 / 12 LEU A  97
LEU A 117
ILE A 165
THR A 110
ALA A 130
LEU A 147
 None
 0.99A 5ienB-2o6wA:
undetectable		 5ienB-2o6wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 GLU A 166
LEU A 142
GLY A 124
ASN A 126
LEU A 107
 None
 1.27A 5kbwA-2o6wA:
undetectable		 5kbwA-2o6wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN
(Cyanothece) 		5 / 12 ILE A 100
LEU A 102
GLY A 139
ALA A 140
LEU A 142
 None
 1.14A 5zwrA-2o6wA:
undetectable		 5zwrA-2o6wA:
18.88