SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		3 / 4 VAL A 278
TRP A 105
TRP A 276
 None
 1.36A 1gmkC-2o6xA:
undetectable
1gmkD-2o6xA:
undetectable		 1gmkC-2o6xA:
14.06
1gmkD-2o6xA:
14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		7 / 10 GLN A 117
GLY A 121
SER A 122
PHE A 126
SER A 127
ALA A 261
GLY A 165
 None
 1.30A 1stfE-2o6xA:
29.0
1stfI-2o6xA:
undetectable		 1stfE-2o6xA:
30.18
1stfI-2o6xA:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		8 / 10 GLN A 117
GLY A 121
SER A 122
TRP A 124
PHE A 126
SER A 127
HIS A 260
ALA A 261
 None
 0.46A 1stfE-2o6xA:
29.0
1stfI-2o6xA:
undetectable		 1stfE-2o6xA:
30.18
1stfI-2o6xA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 6 LEU A 151
LEU A 180
PRO A 311
VAL A 313
 None
 1.03A 2dqyC-2o6xA:
undetectable		 2dqyC-2o6xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 12 VAL A 224
GLY A 268
ALA A 308
GLY A 266
ILE A 247
 None
 0.89A 2v0zO-2o6xA:
undetectable		 2v0zO-2o6xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 9 ALA A 231
ALA A 308
SER A 306
GLY A 303
ALA A 233
 None
 1.36A 2vh3A-2o6xA:
undetectable		 2vh3A-2o6xA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 12 ALA A 231
PHE A 126
GLY A 130
THR A 131
VAL A 111
 None
 1.12A 2zifB-2o6xA:
undetectable		 2zifB-2o6xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 7 GLN A 117
GLY A 121
HIS A 260
TRP A 282
 None
 0.35A 3ai8A-2o6xA:
25.1		 3ai8A-2o6xA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		3 / 3 ARG A 257
GLU A 237
ASN A 259
 None
 0.92A 4imaD-2o6xA:
undetectable		 4imaD-2o6xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		3 / 3 ARG A 257
GLU A 237
ASN A 259
 None
 0.89A 4ip7D-2o6xA:
undetectable		 4ip7D-2o6xA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 5 GLY A 123
SER A 122
ALA A 125
GLU A 148
 None
 1.01A 4m93B-2o6xA:
undetectable
4m93C-2o6xA:
undetectable		 4m93B-2o6xA:
22.15
4m93C-2o6xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 4 LYS A 115
ASP A 153
GLU A 183
THR A 129
 None
 1.48A 5d4uA-2o6xA:
undetectable		 5d4uA-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 4 LYS A 115
ASP A 153
GLU A 183
THR A 129
 None
 1.49A 5d4uB-2o6xA:
undetectable		 5d4uB-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 4 LYS A 115
ASP A 153
GLU A 183
THR A 129
 None
 1.48A 5d4uC-2o6xA:
undetectable		 5d4uC-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 4 LYS A 115
ASP A 153
GLU A 183
THR A 129
 None
 1.47A 5d4uD-2o6xA:
undetectable		 5d4uD-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 9 MET A 312
GLY A 225
ALA A 230
VAL A 224
ILE A 103
 None
 1.50A 5i3cA-2o6xA:
undetectable		 5i3cA-2o6xA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 12 ALA A 231
TYR A 248
TYR A  56
GLY A  59
HIS A 260
 None
 1.18A 5jlcA-2o6xA:
undetectable		 5jlcA-2o6xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 12 THR A 128
THR A 131
SER A 122
GLY A 123
ALA A 261
 None
 1.40A 5lf3b-2o6xA:
undetectable		 5lf3b-2o6xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		5 / 12 THR A 128
THR A 131
SER A 122
GLY A 123
ALA A 261
 None
 1.40A 5lf3N-2o6xA:
undetectable		 5lf3N-2o6xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 8 THR A 269
TYR A 275
ARG A 298
GLN A 249
 None
 1.10A 5tzoB-2o6xA:
undetectable		 5tzoB-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 8 THR A 269
TYR A 275
ARG A 298
GLN A 249
 None
 1.02A 5tzoC-2o6xA:
undetectable		 5tzoC-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 4 GLY A 283
LEU A 284
VAL A 114
GLU A 113
 None
 1.18A 5yw0A-2o6xA:
undetectable		 5yw0A-2o6xA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 5 GLN A 135
THR A 131
HIS A 213
LEU A 223
 None
 1.06A 6aphA-2o6xA:
undetectable		 6aphA-2o6xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2o6x SECRETED CATHEPSIN L
1
(Fasciola
hepatica) 		4 / 5 GLN A 135
THR A 131
HIS A 213
LEU A 223
 None
 1.11A 6gbnB-2o6xA:
undetectable		 6gbnB-2o6xA:
20.18