SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 115
LEU A  13
LEU A 108
LEU A 323
ALA A 329
 None
 1.06A 1bzfA-2o78A:
undetectable		 1bzfA-2o78A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 8 MET A 405
GLN A 408
GLU A 383
ASP A 382
ARG A 379
 None
 1.30A 1dtlA-2o78A:
undetectable		 1dtlA-2o78A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 191
GLY A 120
THR A 125
LEU A 193
ASP A 332
 None
 1.04A 1liiA-2o78A:
undetectable		 1liiA-2o78A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A  82
THR A  81
ALA A  84
LEU A 199
ILE A  53
 None
 1.00A 1qknA-2o78A:
undetectable		 1qknA-2o78A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 320
ASP A  20
ASN A 215
 None
 0.75A 2bm9D-2o78A:
undetectable		 2bm9D-2o78A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 369
VAL A 368
LEU A 222
LEU A 362
THR A 364
 None
 0.95A 2egvA-2o78A:
undetectable		 2egvA-2o78A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 369
VAL A 368
LEU A 222
LEU A 362
THR A 364
 None
 0.94A 2egvB-2o78A:
undetectable		 2egvB-2o78A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 8 HIS A 346
ALA A 344
LEU A  62
THR A  63
 None
 0.83A 2it4A-2o78A:
undetectable		 2it4A-2o78A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 465
LEU A 500
ARG A 504
LEU A 473
CYH A 236
 None
 1.07A 2oaxA-2o78A:
undetectable		 2oaxA-2o78A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 465
LEU A 500
ARG A 504
LEU A 473
CYH A 236
 None
 1.04A 2oaxE-2o78A:
undetectable		 2oaxE-2o78A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 229
THR A 230
LEU A 237
LEU A 380
ILE A 459
 None
 1.07A 2ouzA-2o78A:
undetectable		 2ouzA-2o78A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 LEU A 233
ARG A 273
ARG A 238
GLY A 388
 None
 1.06A 3hcrB-2o78A:
undetectable		 3hcrB-2o78A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 LEU A 467
ARG A 379
SER A 483
GLY A 239
 None
 1.06A 3hcrB-2o78A:
undetectable		 3hcrB-2o78A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 6 VAL A  87
LEU A  49
ILE A 126
ALA A 198
 None
 0.87A 3kk6B-2o78A:
0.0		 3kk6B-2o78A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 8 ARG A  31
LEU A  34
LEU A 108
ILE A 126
 None
 0.79A 3ln1A-2o78A:
0.0		 3ln1A-2o78A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 ARG A  31
LEU A  34
LEU A 108
ILE A 126
 None
 0.76A 3ln1B-2o78A:
undetectable		 3ln1B-2o78A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 517
LEU A 465
ILE A 510
ALA A 511
GLU A 509
 None
 1.14A 3mdvA-2o78A:
undetectable		 3mdvA-2o78A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 HIS A 354
GLY A 352
GLU A 326
ALA A 356
 None
 0.94A 3tehB-2o78A:
undetectable		 3tehB-2o78A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 8 SER A 143
LEU A 161
ALA A 157
THR A 154
 None
 1.00A 4ikjA-2o78A:
undetectable
4ikjB-2o78A:
undetectable		 4ikjA-2o78A:
12.57
4ikjB-2o78A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 ASP A 197
THR A 125
SER A 194
HIS A 195
 None
 1.37A 4o4dA-2o78A:
undetectable		 4o4dA-2o78A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 12 CYH A 466
LEU A 467
ALA A 411
ALA A 407
ILE A 459
 None
 0.89A 4x20B-2o78A:
undetectable		 4x20B-2o78A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 8 LEU A 327
ASP A  18
ALA A  22
VAL A  25
 None
 0.80A 4zbqA-2o78A:
1.3		 4zbqA-2o78A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 10 ALA A 373
ILE A 459
GLY A 223
LEU A 222
ALA A 457
 None
 1.18A 5ajqB-2o78A:
undetectable		 5ajqB-2o78A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 ALA A 103
ARG A 185
GLY A 182
GLU A 181
 None
 0.89A 5bs8A-2o78A:
undetectable
5bs8C-2o78A:
undetectable
5bs8D-2o78A:
undetectable		 5bs8A-2o78A:
26.07
5bs8C-2o78A:
26.07
5bs8D-2o78A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 ALA A 103
ARG A 185
GLY A 182
GLU A 181
 None
 0.87A 5btdA-2o78A:
undetectable
5btdB-2o78A:
undetectable
5btdC-2o78A:
undetectable		 5btdA-2o78A:
26.07
5btdB-2o78A:
21.03
5btdC-2o78A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 6 ALA A 103
ARG A 185
GLY A 182
GLU A 181
 None
 0.87A 5btgA-2o78A:
undetectable
5btgB-2o78A:
undetectable
5btgC-2o78A:
undetectable		 5btgA-2o78A:
26.07
5btgB-2o78A:
21.03
5btgC-2o78A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 7 ALA A 103
ARG A 185
GLY A 182
GLU A 181
 None
 0.86A 5btgA-2o78A:
undetectable
5btgC-2o78A:
undetectable
5btgD-2o78A:
undetectable		 5btgA-2o78A:
26.07
5btgC-2o78A:
26.07
5btgD-2o78A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 6 VAL A 214
HIS A  23
HIS A 221
LEU A 518
 None
 1.47A 5hrqH-2o78A:
undetectable
5hrqK-2o78A:
undetectable
5hrqL-2o78A:
undetectable		 5hrqH-2o78A:
4.58
5hrqK-2o78A:
2.67
5hrqL-2o78A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 11 ALA A 411
THR A 412
ALA A 413
GLY A 406
ALA A 407
 None
 1.04A 5lf3K-2o78A:
undetectable
5lf3L-2o78A:
undetectable		 5lf3K-2o78A:
17.17
5lf3L-2o78A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 10 PRO A 139
LEU A 129
ILE A 114
ALA A 121
VAL A 202
 None
 1.31A 5m0oA-2o78A:
undetectable		 5m0oA-2o78A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		5 / 9 THR A 331
SER A 113
ILE A 114
THR A 205
SER A 206
 None
 1.45A 5muoA-2o78A:
2.8
5muoB-2o78A:
2.9
5muoC-2o78A:
2.8
5muoD-2o78A:
2.8
5muoE-2o78A:
2.7		 5muoA-2o78A:
9.94
5muoB-2o78A:
9.94
5muoC-2o78A:
9.94
5muoD-2o78A:
9.94
5muoE-2o78A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 6 HIS A 158
VAL A 141
LEU A 156
THR A 154
 None
 1.23A 5ogjA-2o78A:
undetectable		 5ogjA-2o78A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 6 HIS A 158
VAL A 141
LEU A 156
THR A 154
 None
 1.24A 5ohhB-2o78A:
undetectable		 5ohhB-2o78A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE
(Rhodobacter
sphaeroides) 		4 / 6 LEU A 201
THR A 331
LEU A 129
GLU A 123
 None
 0.96A 5tudD-2o78A:
2.6		 5tudD-2o78A:
23.09