SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		3 / 3 TRP A 252
ARG A 237
THR A 269
 None
NAP  A 402 (-4.3A)
None
 0.95A 1df7A-2o7pA:
12.0		 1df7A-2o7pA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 9 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.46A 1ereA-2o7pA:
undetectable		 1ereA-2o7pA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 9 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.46A 1ereB-2o7pA:
undetectable		 1ereB-2o7pA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 9 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.48A 1ereC-2o7pA:
undetectable		 1ereC-2o7pA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 9 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.45A 1ereD-2o7pA:
undetectable		 1ereD-2o7pA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		3 / 3 GLU A  52
HIS A  50
ASP A 102
 None
 0.77A 1i9gA-2o7pA:
2.1		 1i9gA-2o7pA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		4 / 8 LEU A 364
LEU A 153
GLY A 154
ILE A 321
 None
None
NAP  A 402 ( 4.8A)
None
 0.93A 1n13A-2o7pA:
undetectable
1n13F-2o7pA:
undetectable		 1n13A-2o7pA:
9.34
1n13F-2o7pA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 10 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.32A 1qkuA-2o7pA:
undetectable		 1qkuA-2o7pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 10 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.33A 1qkuB-2o7pA:
undetectable		 1qkuB-2o7pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 10 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.32A 1qkuC-2o7pA:
undetectable		 1qkuC-2o7pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 LEU A  72
ALA A 131
GLU A 132
ARG A 143
LEU A 112
 None
 1.14A 1s9pA-2o7pA:
undetectable		 1s9pA-2o7pA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 LEU A  72
ALA A 131
GLU A 132
ARG A 143
LEU A 112
 None
 1.14A 1s9pD-2o7pA:
undetectable		 1s9pD-2o7pA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		3 / 3 SER A 187
ASP A 179
CYH A 361
 None
 0.91A 2br4E-2o7pA:
undetectable		 2br4E-2o7pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 PHE A 146
GLY A 145
GLY A 289
ILE A 230
LEU A 279
 None
 0.84A 2nxeA-2o7pA:
2.2		 2nxeA-2o7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		4 / 7 ILE A 321
LEU A 364
LEU A 153
GLY A 154
 None
None
None
NAP  A 402 ( 4.8A)
 0.96A 2qqcD-2o7pA:
undetectable
2qqcE-2o7pA:
undetectable		 2qqcD-2o7pA:
14.81
2qqcE-2o7pA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 PHE A 146
GLY A 145
GLY A 289
ILE A 230
LEU A 279
 None
 0.77A 2zbpA-2o7pA:
undetectable		 2zbpA-2o7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 10 ALA A 189
LEU A 288
ALA A 254
ILE A 232
LEU A 304
 None
None
None
NAP  A 402 ( 4.8A)
NAP  A 402 (-4.0A)
 1.11A 3fl9A-2o7pA:
13.7		 3fl9A-2o7pA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 10 ALA A 189
LEU A 288
ALA A 254
ILE A 232
LEU A 304
 None
None
None
NAP  A 402 ( 4.8A)
NAP  A 402 (-4.0A)
 1.08A 3fl9F-2o7pA:
13.7		 3fl9F-2o7pA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 GLU A 130
ALA A 131
LEU A 134
GLY A 125
SER A  99
 None
 1.06A 3g2oA-2o7pA:
undetectable		 3g2oA-2o7pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 GLU A 130
ALA A 131
LEU A 134
GLY A 125
SER A  99
 None
 1.04A 3g2oB-2o7pA:
undetectable		 3g2oB-2o7pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
 None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
 1.18A 3ut5B-2o7pA:
undetectable		 3ut5B-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		3 / 3 ARG A 229
GLU A 250
THR A 266
 None
 0.74A 3v4tA-2o7pA:
undetectable		 3v4tA-2o7pA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		4 / 5 LEU A 333
ALA A 305
MET A 163
THR A 161
 None
None
NAP  A 402 (-3.5A)
NAP  A 402 (-4.2A)
 1.14A 3vasB-2o7pA:
undetectable		 3vasB-2o7pA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 294
ILE A 293
TRP A 252
 None
 1.09A 4d39A-2o7pA:
undetectable		 4d39A-2o7pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		3 / 3 GLU A  52
HIS A  50
ASP A 102
 None
 0.74A 5c0oG-2o7pA:
undetectable		 5c0oG-2o7pA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
 None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
 1.14A 5eypB-2o7pA:
undetectable		 5eypB-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 12 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
 None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
 1.21A 5nm5B-2o7pA:
undetectable		 5nm5B-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		4 / 8 LEU A 304
ILE A 149
LEU A 270
ALA A 254
 NAP  A 402 (-4.0A)
None
None
None
 0.83A 5y7pC-2o7pA:
undetectable		 5y7pC-2o7pA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Escherichia
coli) 		5 / 10 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.47A 6cbzB-2o7pA:
undetectable		 6cbzB-2o7pA:
13.01