SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.78A 1c6yB-2o7qA:
undetectable		 1c6yB-2o7qA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 GLU A 167
ARG A 170
ARG A 171
GLU A 194
 None
 1.01A 1cmaA-2o7qA:
undetectable
1cmaB-2o7qA:
undetectable		 1cmaA-2o7qA:
11.84
1cmaB-2o7qA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.77A 1hsgB-2o7qA:
undetectable		 1hsgB-2o7qA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 5 ARG A 317
LEU A 148
ASP A 121
LEU A  95
 None
 1.27A 1n13B-2o7qA:
undetectable
1n13C-2o7qA:
undetectable		 1n13B-2o7qA:
12.87
1n13C-2o7qA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.81A 1sdtB-2o7qA:
undetectable		 1sdtB-2o7qA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.80A 1sdvB-2o7qA:
undetectable		 1sdvB-2o7qA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 110
LEU A 294
ALA A 115
GLU A 117
 None
 1.29A 1xvaA-2o7qA:
2.7
1xvaB-2o7qA:
4.5		 1xvaA-2o7qA:
20.11
1xvaB-2o7qA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.84A 2avoB-2o7qA:
undetectable		 2avoB-2o7qA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.85A 2avvB-2o7qA:
undetectable		 2avvB-2o7qA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.82A 2avvE-2o7qA:
undetectable		 2avvE-2o7qA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 488
VAL A 458
GLY A 471
 None
None
CSO  A 424 ( 3.4A)
 0.62A 2avvE-2o7qA:
undetectable		 2avvE-2o7qA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.81A 2bpxB-2o7qA:
undetectable		 2bpxB-2o7qA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 ASN A 421
ASP A 396
GLY A 471
TYR A 470
 CSO  A 424 ( 4.2A)
None
CSO  A 424 ( 3.4A)
None
 0.93A 2f6dA-2o7qA:
undetectable		 2f6dA-2o7qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.83A 2fxeB-2o7qA:
undetectable		 2fxeB-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 ASN A 134
ILE A 142
MET A 108
 None
 0.76A 2h42C-2o7qA:
undetectable		 2h42C-2o7qA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.79A 2o4kB-2o7qA:
undetectable		 2o4kB-2o7qA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.80A 2o4lB-2o7qA:
undetectable		 2o4lB-2o7qA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.81A 2o4sB-2o7qA:
undetectable		 2o4sB-2o7qA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 LEU A 289
LEU A 148
PHE A 291
 None
None
DHK  A9241 (-3.4A)
 0.61A 2pgrA-2o7qA:
3.7		 2pgrA-2o7qA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.82A 2qakA-2o7qA:
undetectable		 2qakA-2o7qA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 462
ALA A 461
ILE A 402
VAL A 479
ILE A 481
 SO4  A1401 (-3.4A)
None
None
None
None
 1.00A 2qakB-2o7qA:
undetectable		 2qakB-2o7qA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.83A 2r5pB-2o7qA:
undetectable		 2r5pB-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.83A 2r5pD-2o7qA:
undetectable		 2r5pD-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.83A 2r5qB-2o7qA:
undetectable		 2r5qB-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 10 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.83A 2r5qD-2o7qA:
undetectable		 2r5qD-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 557
LEU A 558
ASP A 547
ILE A 459
 None
 1.16A 2rlfB-2o7qA:
undetectable
2rlfC-2o7qA:
undetectable		 2rlfB-2o7qA:
5.16
2rlfC-2o7qA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.77A 3d1yA-2o7qA:
undetectable		 3d1yA-2o7qA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 236
ALA A 237
ASP A 238
ILE A 232
 None
 0.56A 3el0A-2o7qA:
undetectable		 3el0A-2o7qA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.85A 3el1B-2o7qA:
undetectable		 3el1B-2o7qA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 THR A 407
VAL A 333
LEU A 359
ILE A 328
TYR A 355
 None
None
None
DHK  A4733 (-3.9A)
None
 1.42A 3elzC-2o7qA:
undetectable		 3elzC-2o7qA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 10 ILE A 249
VAL A 325
GLY A 377
VAL A 333
LEU A 363
 None
None
None
None
CSO  A 391 ( 4.4A)
 1.27A 3em0A-2o7qA:
undetectable		 3em0A-2o7qA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.82A 3em4A-2o7qA:
undetectable		 3em4A-2o7qA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 4 GLN A 526
PRO A 527
VAL A 529
GLU A 531
 None
 1.50A 3huoA-2o7qA:
undetectable		 3huoA-2o7qA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.74A 3jw2B-2o7qA:
undetectable		 3jw2B-2o7qA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 SER A 429
PHE A 575
LEU A 468
ASP A 423
 None
None
None
DHK  A4733 (-2.8A)
 1.01A 3m0wE-2o7qA:
undetectable
3m0wF-2o7qA:
undetectable
3m0wG-2o7qA:
undetectable
3m0wH-2o7qA:
undetectable		 3m0wE-2o7qA:
11.31
3m0wF-2o7qA:
11.31
3m0wG-2o7qA:
11.31
3m0wH-2o7qA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 VAL A 187
SER A 212
ILE A 232
GLY A 236
ALA A 237
 None
 1.13A 3n8yA-2o7qA:
undetectable		 3n8yA-2o7qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 ARG A 488
GLY A 465
GLY A 460
GLU A 386
ALA A 464
 None
None
None
SO4  A1401 (-3.8A)
None
 1.31A 3t7sC-2o7qA:
undetectable		 3t7sC-2o7qA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.80A 3tl9A-2o7qA:
undetectable		 3tl9A-2o7qA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 MET A 574
PHE A 546
PHE A 575
LEU A 558
GLN A 526
 None
 1.36A 4dx7A-2o7qA:
0.1		 4dx7A-2o7qA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 PHE A 586
HIS A 357
THR A 381
SER A 336
GLY A 330
 None
None
DHK  A4733 (-3.9A)
DHK  A4733 (-2.5A)
None
 1.45A 4hvcA-2o7qA:
5.8		 4hvcA-2o7qA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 SER A 297
LEU A 609
SER A 296
THR A 306
 None
 0.98A 4ikjA-2o7qA:
undetectable
4ikjB-2o7qA:
undetectable		 4ikjA-2o7qA:
12.82
4ikjB-2o7qA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.81A 4jecA-2o7qA:
undetectable		 4jecA-2o7qA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 151
VAL A 123
PRO A 149
LYS A 208
ILE A 185
 None
 1.28A 4lb2B-2o7qA:
0.0		 4lb2B-2o7qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 9 ASN A 483
ALA A 489
GLY A 498
ILE A 496
ILE A 459
 SO4  A1402 (-4.0A)
None
None
None
None
 1.15A 4nptA-2o7qA:
undetectable		 4nptA-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 482
ALA A 518
ALA A 464
GLY A 465
LEU A 468
 None
 1.04A 4oaeA-2o7qA:
undetectable		 4oaeA-2o7qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 PHE A 586
HIS A 357
THR A 381
SER A 336
GLY A 330
 None
None
DHK  A4733 (-3.9A)
DHK  A4733 (-2.5A)
None
 1.45A 4olfA-2o7qA:
4.1		 4olfA-2o7qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 388
LEU A 417
ASP A 423
ASN A 421
TYR A 355
 None
CSO  A 391 ( 4.6A)
DHK  A4733 (-2.8A)
CSO  A 424 ( 4.2A)
None
 0.87A 4pclA-2o7qA:
5.0		 4pclA-2o7qA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 PHE A 291
SER A 300
ALA A 243
LEU A 269
 DHK  A9241 (-3.4A)
DHK  A9241 (-2.8A)
DHK  A9241 ( 4.6A)
DHK  A9241 (-3.7A)
 0.96A 4rkuA-2o7qA:
undetectable
4rkuJ-2o7qA:
undetectable		 4rkuA-2o7qA:
20.52
4rkuJ-2o7qA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 506
LEU A 468
ALA A 464
ALA A 518
GLY A 460
 None
 1.30A 4rn6A-2o7qA:
0.0		 4rn6A-2o7qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 10 ALA A 182
THR A 112
ILE A 125
THR A 150
LEU A 127
 None
 0.93A 4rz7A-2o7qA:
undetectable		 4rz7A-2o7qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 PHE A 291
SER A 300
ALA A 243
LEU A 269
 DHK  A9241 (-3.4A)
DHK  A9241 (-2.8A)
DHK  A9241 ( 4.6A)
DHK  A9241 (-3.7A)
 1.02A 4xk8A-2o7qA:
undetectable		 4xk8A-2o7qA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 292
GLY A 303
THR A 290
ASP A 121
ILE A 307
 None
 0.89A 5ikmA-2o7qA:
undetectable		 5ikmA-2o7qA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 236
ALA A 237
ASP A 238
ILE A 210
ILE A 232
 None
 0.81A 5kqxA-2o7qA:
undetectable		 5kqxA-2o7qA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 VAL A 457
LEU A 517
ILE A 534
ASN A 508
 None
 0.71A 5numA-2o7qA:
undetectable		 5numA-2o7qA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 509
VAL A 457
ILE A 459
ALA A 482
 None
 0.71A 5ospA-2o7qA:
undetectable		 5ospA-2o7qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 509
VAL A 457
ILE A 459
ALA A 482
 None
 0.65A 5osrA-2o7qA:
undetectable		 5osrA-2o7qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 276
GLY A 275
GLY A 272
VAL A 270
LEU A 281
 None
 1.21A 5uc1A-2o7qA:
undetectable		 5uc1A-2o7qA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 4 GLY A 303
PRO A 302
VAL A 299
ARG A 279
 None
None
None
DHK  A9241 (-2.7A)
 1.25A 5uunA-2o7qA:
0.0
5uunB-2o7qA:
0.0		 5uunA-2o7qA:
20.88
5uunB-2o7qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLU A 531
VAL A 529
PRO A 552
THR A 551
THR A 381
 None
None
None
None
DHK  A4733 (-3.9A)
 1.25A 5xioB-2o7qA:
5.2		 5xioB-2o7qA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 10 ASN A 483
ARG A 488
GLU A 491
GLY A 465
ILE A 496
 SO4  A1402 (-4.0A)
None
None
None
None
 1.17A 6bniA-2o7qA:
undetectable		 6bniA-2o7qA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 10 ASN A 483
ARG A 488
GLU A 491
GLY A 465
ILE A 496
 SO4  A1402 (-4.0A)
None
None
None
None
 1.20A 6bniB-2o7qA:
undetectable		 6bniB-2o7qA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 GLY A 236
ASP A 238
ILE A 210
 None
 0.58A 6dgxB-2o7qA:
undetectable		 6dgxB-2o7qA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 267
SER A 212
LEU A  95
ASP A 186
ILE A 232
 None
 1.25A 6dwnB-2o7qA:
undetectable		 6dwnB-2o7qA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 ILE A 280
GLU A 273
HIS A 357
VAL A 356
 None
 1.00A 6j20A-2o7qA:
undetectable		 6j20A-2o7qA:
20.64