SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 8 SER B 470
GLN B 522
GLY B 529
GLY B 467
 None
 0.66A 1aq7A-2o8eB:
undetectable		 1aq7A-2o8eB:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 4 VAL B 480
PHE B 466
SER B 470
VAL B 474
 None
 1.37A 1e7cA-2o8eB:
0.0		 1e7cA-2o8eB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.20A 1hrkB-2o8eB:
undetectable		 1hrkB-2o8eB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 11 LEU B 887
LYS B 883
VAL B 878
PRO B 802
LEU B 798
 None
 1.20A 1klmA-2o8eB:
undetectable		 1klmA-2o8eB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 11 LEU B1063
ALA B 787
VAL B 762
MET B1156
LEU B 778
 None
 1.36A 1kt6A-2o8eB:
undetectable		 1kt6A-2o8eB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 11 LEU B1063
ALA B 787
VAL B 762
MET B1156
LEU B 778
 None
 1.36A 1kt7A-2o8eB:
undetectable		 1kt7A-2o8eB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 7 GLN B1146
MET B1153
MET B1074
ALA B1162
 None
 1.25A 1linA-2o8eB:
undetectable		 1linA-2o8eB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 7 MET B1074
MET B1156
MET B1153
ALA B1154
 None
 1.35A 1linA-2o8eB:
undetectable		 1linA-2o8eB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 5 TYR B 556
PHE B 582
ILE B 608
ARG B 554
 None
 1.49A 1vaoA-2o8eB:
0.0		 1vaoA-2o8eB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 5 TYR B 556
PHE B 582
ILE B 608
ARG B 554
 None
 1.49A 1vaoB-2o8eB:
0.0		 1vaoB-2o8eB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 GLY B 770
ASP B1058
ASN B 534
 None
 0.65A 1vq1A-2o8eB:
2.4		 1vq1A-2o8eB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 4 LEU B 473
SER B 470
TYR B 469
LEU B 447
 None
 1.21A 1xz1A-2o8eB:
2.3		 1xz1A-2o8eB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 4 LEU B 473
SER B 470
TYR B 469
LEU B 447
 None
 1.20A 1xz3A-2o8eB:
undetectable		 1xz3A-2o8eB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 6 ASP B 736
ARG B1172
ASP B1171
THR B 716
 None
 1.12A 2j2pE-2o8eB:
undetectable
2j2pF-2o8eB:
undetectable		 2j2pE-2o8eB:
12.84
2j2pF-2o8eB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 LEU B 684
LEU B 638
PHE B 706
 None
 0.46A 2pgrA-2o8eB:
undetectable		 2pgrA-2o8eB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.24A 2pnjB-2o8eB:
undetectable		 2pnjB-2o8eB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.19A 2po5A-2o8eB:
undetectable		 2po5A-2o8eB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.19A 2po7A-2o8eB:
undetectable		 2po7A-2o8eB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 ASP B1026
THR B 488
PRO B 489
 None
 0.65A 2pynB-2o8eB:
undetectable		 2pynB-2o8eB:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 ASP B1026
THR B 488
PRO B 489
 None
 0.66A 2q64B-2o8eB:
undetectable		 2q64B-2o8eB:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 ASP B1026
THR B 488
PRO B 489
 None
 0.63A 2qakB-2o8eB:
undetectable		 2qakB-2o8eB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 6 SER B 682
PRO B 623
GLY B 624
TRP B 628
 None
 1.47A 2y7pA-2o8eB:
undetectable		 2y7pA-2o8eB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 5 THR B 750
THR B1142
HIS B1096
LEU B1149
 None
 1.31A 2zj0A-2o8eB:
undetectable		 2zj0A-2o8eB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.20A 3aqiB-2o8eB:
undetectable		 3aqiB-2o8eB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B1167
LEU B1091
ILE B 788
SER B1094
PRO B1097
 None
 1.33A 3aqiB-2o8eB:
undetectable		 3aqiB-2o8eB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 5 THR B 750
THR B1142
HIS B1096
LEU B1149
 None
 1.33A 3ce6A-2o8eB:
undetectable		 3ce6A-2o8eB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 5 THR B 750
THR B1142
HIS B1096
LEU B1149
 None
 1.31A 3ce6C-2o8eB:
undetectable		 3ce6C-2o8eB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 LEU B 862
LEU B 909
ARG B 911
 None
 0.72A 3hcnB-2o8eB:
undetectable		 3hcnB-2o8eB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 ARG B 732
GLU B 707
TYR B 589
 None
 0.85A 3k37B-2o8eB:
undetectable		 3k37B-2o8eB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 6 TYR B1159
ASN B 789
LEU B 792
ASP B 793
 None
 1.34A 3lslG-2o8eB:
undetectable		 3lslG-2o8eB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.24A 3w1wA-2o8eB:
undetectable		 3w1wA-2o8eB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.21A 3w1wB-2o8eB:
undetectable		 3w1wB-2o8eB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 ALA B 879
ILE B 874
ILE B 871
LEU B 893
ILE B1054
 None
 0.98A 4azvA-2o8eB:
undetectable		 4azvA-2o8eB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 7 ASN B 600
LEU B 601
GLY B 557
TYR B 556
 None
 1.01A 4cp3A-2o8eB:
undetectable
4cp3B-2o8eB:
undetectable		 4cp3A-2o8eB:
8.78
4cp3B-2o8eB:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 6 SER B 714
ARG B 581
GLY B 557
GLY B 571
 None
 0.89A 4koeA-2o8eB:
0.3
4koeB-2o8eB:
undetectable
4koeC-2o8eB:
undetectable		 4koeA-2o8eB:
18.70
4koeB-2o8eB:
18.70
4koeC-2o8eB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 7 ARG B 581
SER B 714
GLY B 557
GLY B 571
 None
 0.91A 4koeA-2o8eB:
undetectable
4koeB-2o8eB:
undetectable
4koeD-2o8eB:
undetectable		 4koeA-2o8eB:
18.70
4koeB-2o8eB:
18.70
4koeD-2o8eB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 7 ASN B1020
GLU B 946
GLU B1023
ARG B1025
 None
 0.71A 4mi4B-2o8eB:
undetectable
4mi4C-2o8eB:
undetectable		 4mi4B-2o8eB:
11.23
4mi4C-2o8eB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 8 ASN B1020
GLU B 946
GLU B1023
ARG B1025
 None
 0.73A 4mj8B-2o8eB:
undetectable
4mj8C-2o8eB:
undetectable		 4mj8B-2o8eB:
11.19
4mj8C-2o8eB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 GLY B 467
GLY B 529
ARG B 482
SER B 470
LEU B 447
 None
 1.12A 4mwzA-2o8eB:
undetectable		 4mwzA-2o8eB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 GLY B1216
ILE B1227
ALA B1228
PHE B1245
VAL B1231
 None
 1.13A 4u8yB-2o8eB:
2.4		 4u8yB-2o8eB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 10 LEU B1131
ASP B1255
TYR B1256
SER B1257
ALA B1228
 None
 1.02A 4xj7C-2o8eB:
undetectable
4xj7D-2o8eB:
undetectable		 4xj7C-2o8eB:
14.53
4xj7D-2o8eB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 6 GLY B 557
GLY B 571
SER B 714
ARG B 581
 None
 0.87A 4z53A-2o8eB:
undetectable
4z53B-2o8eB:
2.5		 4z53A-2o8eB:
21.76
4z53B-2o8eB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 7 ARG B 581
GLY B 557
GLY B 571
SER B 714
 None
 0.92A 4z53A-2o8eB:
undetectable
4z53B-2o8eB:
2.7		 4z53A-2o8eB:
21.76
4z53B-2o8eB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 12 SER B 564
GLN B 522
VAL B 474
GLN B 593
TYR B 524
 None
 1.45A 4zj8A-2o8eB:
3.6		 4zj8A-2o8eB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 10 PHE B 573
LEU B 601
GLU B 544
LEU B 542
THR B 605
 None
 1.23A 4zmeB-2o8eB:
undetectable		 4zmeB-2o8eB:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 8 LEU B1209
LEU B1211
LEU B1091
LEU B1089
 None
 0.67A 5jqbA-2o8eB:
undetectable
5jqbB-2o8eB:
undetectable		 5jqbA-2o8eB:
15.83
5jqbB-2o8eB:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 6 THR B 407
GLY B 409
TYR B 436
ILE B 425
 None
 0.89A 5kmfA-2o8eB:
3.4
5kmfC-2o8eB:
3.4		 5kmfA-2o8eB:
14.69
5kmfC-2o8eB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 5 HIS B1317
ILE B1313
SER B1297
ALA B1303
 None
 1.01A 5msdA-2o8eB:
undetectable		 5msdA-2o8eB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 VAL B 558
TYR B 556
GLN B 572
 None
 0.66A 5qgkA-2o8eB:
undetectable		 5qgkA-2o8eB:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 VAL B 558
TYR B 556
GLN B 572
 None
 0.68A 5qgrA-2o8eB:
undetectable		 5qgrA-2o8eB:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		3 / 3 VAL B 558
TYR B 556
GLN B 572
 None
 0.70A 5qgtA-2o8eB:
undetectable		 5qgtA-2o8eB:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		5 / 11 GLY B1148
ALA B1147
ALA B1151
ILE B1170
VAL B1173
 None
 1.18A 5yk2A-2o8eB:
0.2		 5yk2A-2o8eB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens) 		4 / 8 ALA B 555
GLY B 557
LEU B 679
LYS B 676
 None
 0.81A 6mdqA-2o8eB:
undetectable		 6mdqA-2o8eB:
6.01