SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 8 LEU A 491
ALA A 457
ILE A 611
PHE A 504
VAL A 488
 None
 1.29A 1d4sB-2o8rA:
undetectable		 1d4sB-2o8rA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 GLN A  92
TYR A  96
SER A  44
TYR A  51
ASN A 300
 None
SO4  A 705 (-3.4A)
SO4  A 705 (-2.6A)
None
None
 1.43A 1rkwA-2o8rA:
0.3		 1rkwA-2o8rA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 PHE A 206
TYR A 101
TYR A  97
 None
None
SO4  A 705 (-4.5A)
 0.95A 1x70B-2o8rA:
0.7		 1x70B-2o8rA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 8 TYR A 512
PHE A 504
ALA A 438
LEU A 495
 None
 0.95A 1x8vA-2o8rA:
undetectable		 1x8vA-2o8rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 PRO A 123
THR A 121
PRO A 120
 None
SO4  A 709 (-3.9A)
SO4  A 709 (-4.7A)
 0.85A 2d55C-2o8rA:
undetectable		 2d55C-2o8rA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 7 TYR A 349
GLN A 677
ARG A 675
ARG A 682
 None
 1.42A 2qmqA-2o8rA:
undetectable		 2qmqA-2o8rA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 141
TYR A 175
SER A 176
TYR A 228
ALA A 178
 None
 1.44A 2vdmA-2o8rA:
undetectable
2vdmB-2o8rA:
undetectable		 2vdmA-2o8rA:
21.75
2vdmB-2o8rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 TYR A 512
PHE A 504
ALA A 438
THR A 374
LEU A 495
 None
 1.20A 2x2nD-2o8rA:
undetectable		 2x2nD-2o8rA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 6 VAL A  89
ARG A  86
ILE A  90
TYR A  51
 None
 1.18A 2yfbB-2o8rA:
4.6		 2yfbB-2o8rA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 HIS A 595
LEU A 593
GLY A 569
LEU A 565
TRP A 616
 SO4  A 707 (-3.8A)
None
None
None
None
 1.14A 3i5uA-2o8rA:
undetectable		 3i5uA-2o8rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 HIS A 595
LEU A 593
GLY A 569
LEU A 565
TRP A 616
 SO4  A 707 (-3.8A)
None
None
None
None
 1.18A 3i5uB-2o8rA:
undetectable		 3i5uB-2o8rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 LYS A 687
ILE A 598
PHE A 610
 None
 0.90A 3j7zS-2o8rA:
undetectable
3j7za-2o8rA:
undetectable		 3j7zS-2o8rA:
10.77
3j7za-2o8rA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 LYS A 687
ILE A 611
PHE A 610
 None
 0.91A 3j7zS-2o8rA:
undetectable
3j7za-2o8rA:
undetectable		 3j7zS-2o8rA:
10.77
3j7za-2o8rA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 ALA A 391
ARG A 357
LEU A 359
ILE A 456
LEU A 458
 None
SO4  A 710 (-3.7A)
None
None
None
 1.17A 3k2hB-2o8rA:
undetectable		 3k2hB-2o8rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 11 THR A 627
LEU A 459
LEU A 442
LEU A 507
LEU A 491
 None
 1.25A 3ndvA-2o8rA:
undetectable
3ndvB-2o8rA:
undetectable		 3ndvA-2o8rA:
19.01
3ndvB-2o8rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 11 LEU A 507
LEU A 491
THR A 627
LEU A 459
LEU A 442
 None
 1.23A 3ndvA-2o8rA:
undetectable
3ndvB-2o8rA:
undetectable		 3ndvA-2o8rA:
19.01
3ndvB-2o8rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 11 THR A 627
LEU A 459
LEU A 442
LEU A 507
LEU A 491
 None
 1.24A 3ndvC-2o8rA:
undetectable
3ndvD-2o8rA:
undetectable		 3ndvC-2o8rA:
19.01
3ndvD-2o8rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 11 LEU A 507
LEU A 491
THR A 627
LEU A 459
LEU A 442
 None
 1.26A 3ndvC-2o8rA:
undetectable
3ndvD-2o8rA:
undetectable		 3ndvC-2o8rA:
19.01
3ndvD-2o8rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 5 LYS A 212
VAL A 299
MET A 144
ARG A 294
 None
 1.16A 3oezA-2o8rA:
undetectable		 3oezA-2o8rA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 ILE A 210
ASP A 209
LEU A 141
ILE A 155
ILE A 230
 None
 1.12A 3pwwA-2o8rA:
undetectable		 3pwwA-2o8rA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 5 VAL A 160
VAL A 182
ARG A 189
LYS A 212
 None
 1.21A 3rv5A-2o8rA:
0.6
3rv5B-2o8rA:
0.5		 3rv5A-2o8rA:
9.21
3rv5B-2o8rA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 9 LEU A 108
THR A 107
VAL A  33
LEU A 304
ILE A  37
 None
 1.21A 3tbgD-2o8rA:
undetectable		 3tbgD-2o8rA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 6 SER A 460
LEU A 458
MET A 478
THR A 476
 None
 0.95A 3thrB-2o8rA:
undetectable		 3thrB-2o8rA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 5 LEU A 162
PRO A 183
VAL A 182
ASP A 209
 None
 0.95A 3ufnA-2o8rA:
undetectable
3ufnB-2o8rA:
undetectable		 3ufnA-2o8rA:
8.98
3ufnB-2o8rA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 6 TYR A  97
ASP A 102
GLU A 109
LEU A  40
 SO4  A 705 (-4.5A)
None
None
None
 1.27A 4ax8A-2o8rA:
undetectable		 4ax8A-2o8rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 7 ASP A  35
ASP A 590
ASP A  28
GLU A  25
 None
 1.23A 4fevD-2o8rA:
undetectable		 4fevD-2o8rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 7 ASP A  35
ASP A 590
ASP A  28
GLU A  25
 None
 1.22A 4fevF-2o8rA:
undetectable		 4fevF-2o8rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 7 ASP A  35
ASP A 590
ASP A  28
GLU A  25
 None
 1.22A 4gkhG-2o8rA:
undetectable		 4gkhG-2o8rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 6 ASP A  35
ASP A 590
ASP A  28
GLU A  25
 None
 1.28A 4gkhJ-2o8rA:
undetectable		 4gkhJ-2o8rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 8 ASP A  35
ASP A 590
ASP A  28
GLU A  25
 None
 1.21A 4gkiA-2o8rA:
undetectable		 4gkiA-2o8rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 8 ARG A 415
LEU A 416
ASN A 381
ILE A 385
 None
 1.03A 4k0bA-2o8rA:
undetectable		 4k0bA-2o8rA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 7 SER A 473
TYR A 592
ARG A 675
GLU A 594
 None
 1.30A 4xzkA-2o8rA:
undetectable		 4xzkA-2o8rA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 ASP A 270
ARG A 272
TYR A 228
 None
 0.95A 5a7mA-2o8rA:
undetectable		 5a7mA-2o8rA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 ASP A 270
ARG A 272
TYR A 228
 None
 0.95A 5a7mB-2o8rA:
2.5		 5a7mB-2o8rA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A  47
LEU A 661
PHE A  50
THR A  88
ALA A  84
 None
 1.27A 5ieoA-2o8rA:
undetectable		 5ieoA-2o8rA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A  51
TYR A  97
SER A 295
 None
SO4  A 705 (-4.5A)
None
 0.96A 5iktB-2o8rA:
undetectable		 5iktB-2o8rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 6 ILE A 384
ALA A 387
LEU A 388
ILE A 371
 None
 0.87A 5mvmB-2o8rA:
4.6
5mvmC-2o8rA:
3.5		 5mvmB-2o8rA:
8.10
5mvmC-2o8rA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 521
ALA A 628
GLN A 552
ARG A 511
LEU A 621
 None
 1.33A 5syfB-2o8rA:
2.7		 5syfB-2o8rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		4 / 8 TYR A  51
VAL A  55
HIS A  58
ILE A  85
 None
 0.93A 5v0vA-2o8rA:
1.4		 5v0vA-2o8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 HIS A 122
HIS A 125
ARG A 116
 None
None
SO4  A 709 ( 3.4A)
 0.87A 6b58A-2o8rA:
4.8		 6b58A-2o8rA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2o8r POLYPHOSPHATE KINASE
(Porphyromonas
gingivalis) 		3 / 3 SER A  45
SER A  41
ALA A 469
 None
None
SO4  A 708 (-3.3A)
 0.71A 6dwnC-2o8rA:
undetectable		 6dwnC-2o8rA:
7.34