SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 LEU A 157
LEU A 162
TYR A  88
GLY A 175
ALA A 171
 None
 1.02A 1cqeA-2o8sA:
undetectable		 1cqeA-2o8sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 LEU A 157
LEU A 162
TYR A  88
GLY A 175
ALA A 171
 None
 1.01A 1cqeB-2o8sA:
undetectable		 1cqeB-2o8sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 11 ASN A 193
VAL A 196
TYR A  58
TYR A  61
GLY A 195
 None
 1.24A 1fkpA-2o8sA:
undetectable		 1fkpA-2o8sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 PHE A 126
LEU A 153
GLY A 134
ALA A 135
LEU A 145
 None
 0.94A 1igxA-2o8sA:
undetectable		 1igxA-2o8sA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		6 / 12 ALA A 206
LEU A 265
ILE A 251
ILE A 253
PHE A 215
LEU A 266
 None
 1.33A 1xdkF-2o8sA:
undetectable		 1xdkF-2o8sA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 LEU A 157
LEU A 162
TYR A  88
GLY A 175
ALA A 171
 None
 1.08A 2aylA-2o8sA:
undetectable		 2aylA-2o8sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 LEU A 157
LEU A 162
TYR A  88
GLY A 175
ALA A 171
 None
 1.04A 2aylB-2o8sA:
undetectable		 2aylB-2o8sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		4 / 5 TYR A  58
SER A  60
TYR A  61
ARG A  62
 None
 1.35A 2kqeA-2o8sA:
0.0		 2kqeA-2o8sA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		4 / 8 MET A 102
PHE A 101
ALA A 154
LEU A 157
 None
 0.98A 2o01A-2o8sA:
undetectable		 2o01A-2o8sA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 10 LEU A 200
VAL A 196
GLY A 195
LEU A 185
ALA A 189
 None
 0.93A 2v3kA-2o8sA:
undetectable		 2v3kA-2o8sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 TRP A 273
PHE A 269
THR A  55
VAL A  54
LEU A 198
 None
 1.10A 3elzA-2o8sA:
undetectable		 3elzA-2o8sA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 10 ASN A 193
VAL A 196
TYR A  58
TYR A  61
GLY A 195
 None
 1.27A 3lp1A-2o8sA:
undetectable		 3lp1A-2o8sA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 LEU A 157
LEU A 162
TYR A  88
GLY A 175
ALA A 171
 None
 1.03A 3n8wA-2o8sA:
undetectable		 3n8wA-2o8sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 LEU A 157
LEU A 162
TYR A  88
GLY A 175
ALA A 171
 None
 0.97A 3n8zA-2o8sA:
undetectable		 3n8zA-2o8sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		4 / 7 LEU A 162
GLU A 170
ALA A 171
ALA A 172
 None
 0.78A 3r9tB-2o8sA:
undetectable		 3r9tB-2o8sA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		4 / 8 ASN A 193
GLY A 195
VAL A 196
ILE A 271
 None
 0.75A 4fglD-2o8sA:
undetectable		 4fglD-2o8sA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		4 / 7 ASN A 193
GLY A 195
VAL A 196
ILE A 271
 None
 0.90A 4fglC-2o8sA:
undetectable		 4fglC-2o8sA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		4 / 7 MET A 102
PHE A 101
ALA A 154
LEU A 157
 None
 1.11A 4xk8A-2o8sA:
undetectable		 4xk8A-2o8sA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		5 / 12 PRO A  25
ALA A 123
ILE A 127
LEU A 117
ALA A 217
 None
 1.25A 5bw4B-2o8sA:
undetectable		 5bw4B-2o8sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		3 / 3 LYS A 205
PRO A 207
LYS A 210
 None
 1.26A 5y9yA-2o8sA:
undetectable		 5y9yA-2o8sA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		3 / 3 MET A 120
ASP A 147
ARG A 204
 None
 1.13A 5z6jA-2o8sA:
undetectable		 5z6jA-2o8sA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2o8s AGR_C_984P
(Agrobacterium
fabrum) 		3 / 3 MET A 120
ASP A 147
ARG A 204
 None
 1.22A 5z6kA-2o8sA:
undetectable		 5z6kA-2o8sA:
17.70