SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 8 TYR A  81
PHE A  83
GLY A  80
THR A  77
 None
 1.02A 1ykiA-2o8vA:
undetectable
1ykiB-2o8vA:
undetectable		 1ykiA-2o8vA:
21.60
1ykiB-2o8vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 8 THR A  77
TYR A  81
PHE A  83
GLY A  80
 None
 1.03A 1ykiA-2o8vA:
undetectable
1ykiB-2o8vA:
undetectable		 1ykiA-2o8vA:
21.60
1ykiB-2o8vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 8 TYR A  81
PHE A  83
GLY A  80
THR A  77
 None
 1.01A 1ykiC-2o8vA:
undetectable
1ykiD-2o8vA:
undetectable		 1ykiC-2o8vA:
21.60
1ykiD-2o8vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 8 THR A  77
TYR A  81
PHE A  83
GLY A  80
 None
 1.03A 1ykiC-2o8vA:
undetectable
1ykiD-2o8vA:
undetectable		 1ykiC-2o8vA:
21.60
1ykiD-2o8vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		5 / 10 LEU A  28
LEU A 170
LEU A   4
LYS A   2
ASN A  43
 None
 1.32A 2ceoB-2o8vA:
undetectable		 2ceoB-2o8vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
THIOREDOXIN 1
(Escherichia
coli) 		5 / 11 ILE B  72
GLY B  92
GLU A 238
LEU B  79
GLY B  74
 None
 1.38A 2fn1A-2o8vB:
undetectable		 2fn1A-2o8vB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 6 LEU A  41
ARG A  69
ILE A  68
ILE A 190
 None
 0.95A 2xkwB-2o8vA:
undetectable		 2xkwB-2o8vA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2o8v THIOREDOXIN 1
(Escherichia
coli) 		5 / 10 ALA B  46
LEU B  94
LEU B  78
LEU B  42
LEU B  99
 None
 1.14A 2xn6A-2o8vB:
undetectable
2xn6B-2o8vB:
undetectable		 2xn6A-2o8vB:
17.38
2xn6B-2o8vB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2o8v THIOREDOXIN 1
(Escherichia
coli) 		4 / 7 PHE B 102
LEU B  80
LEU B  53
LEU B  24
 None
 0.82A 3bgdB-2o8vB:
undetectable		 3bgdB-2o8vB:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2o8v THIOREDOXIN 1
(Escherichia
coli) 		5 / 10 ASN B  83
ALA B  22
LEU B 103
ASN B 106
LEU B 107
 None
 1.20A 3o02A-2o8vB:
undetectable
3o02B-2o8vB:
undetectable		 3o02A-2o8vB:
16.94
3o02B-2o8vB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 8 ASP A 184
ILE A 183
SER A  53
GLN A  57
 None
 0.91A 4acbB-2o8vA:
2.5
4acbC-2o8vA:
2.8		 4acbB-2o8vA:
19.76
4acbC-2o8vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		3 / 3 TYR A 131
THR A  79
GLU A 114
 None
 0.80A 4df3A-2o8vA:
undetectable		 4df3A-2o8vA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		3 / 3 TYR A 131
THR A  79
GLU A 114
 None
 0.77A 4df3B-2o8vA:
undetectable		 4df3B-2o8vA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 190
THR A 189
VAL A 169
ILE A 183
GLU A  29
 None
 1.33A 4i41A-2o8vA:
undetectable		 4i41A-2o8vA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 7 PHE A  89
ALA A  58
SER A  61
ILE A 190
 None
 0.77A 4uymA-2o8vA:
undetectable		 4uymA-2o8vA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2o8v THIOREDOXIN 1
(Escherichia
coli) 		5 / 11 LEU B 103
LEU B  24
LEU B  99
GLU B  44
LEU B  42
 None
 1.00A 4wg0D-2o8vB:
undetectable
4wg0E-2o8vB:
undetectable
4wg0F-2o8vB:
undetectable		 4wg0D-2o8vB:
6.30
4wg0E-2o8vB:
6.30
4wg0F-2o8vB:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2o8v THIOREDOXIN 1
(Escherichia
coli) 		5 / 11 GLU B  44
LEU B  42
LEU B  99
LEU B 103
LEU B  24
 None
 1.02A 4wg0G-2o8vB:
undetectable
4wg0H-2o8vB:
undetectable
4wg0I-2o8vB:
undetectable		 4wg0G-2o8vB:
6.30
4wg0H-2o8vB:
6.30
4wg0I-2o8vB:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		4 / 8 LEU A  93
LEU A  97
LEU A 194
TYR A 193
 None
 0.71A 5jqbA-2o8vA:
undetectable
5jqbB-2o8vA:
undetectable		 5jqbA-2o8vA:
20.92
5jqbB-2o8vA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		5 / 10 GLU A  29
ALA A  38
GLY A  35
ALA A  33
ASP A 184
 None
 1.19A 5lf3H-2o8vA:
undetectable
5lf3I-2o8vA:
undetectable		 5lf3H-2o8vA:
21.45
5lf3I-2o8vA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Escherichia
coli) 		5 / 10 GLU A  29
ALA A  38
GLY A  35
ALA A  33
ASP A 184
 None
 1.19A 5lf3V-2o8vA:
undetectable
5lf3W-2o8vA:
undetectable		 5lf3V-2o8vA:
21.45
5lf3W-2o8vA:
20.91