SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICT_D_T44D129_2 (TRANSTHYRETIN)	2o8x	PROBABLE RNA POLYMERASE SIGMA-C FACTOR (Mycobacterium tuberculosis)	4 / 7	LEU A 141 THR A 162 LEU A 147 SER A 148	None SO4 A 108 (-3.7A) None None	0.60A	1ictD-2o8xA: undetectable	1ictD-2o8xA: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WYG_A_SALA4005_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	2o8x	PROBABLE RNA POLYMERASE SIGMA-C FACTOR (Mycobacterium tuberculosis)	5 / 10	SER A 165 ARG A 166 THR A 162 ALA A 152 GLU A 137	SO4 A 108 ( 3.8A) SO4 A 108 (-4.7A) SO4 A 108 (-3.7A) None None	1.42A	1wygA-2o8xA: undetectable	1wygA-2o8xA: 4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_A_ACTA148_0 (UPF0066 PROTEIN AF_0241)	2o8x	PROBABLE RNA POLYMERASE SIGMA-C FACTOR (Mycobacterium tuberculosis)	3 / 3	VAL A 122 GLU A 119 GLU A 123	None	0.77A	2nv4A-2o8xA: undetectable	2nv4A-2o8xA: 22.63