SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 6 LEU A  72
LEU A  75
SER A  76
THR A  81
 None
 1.27A 1tyrA-2o9aA:
undetectable		 1tyrA-2o9aA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  65
GLY A  68
SER A 145
 PYR  A 905 (-4.3A)
None
PYR  A 905 (-2.7A)
 0.62A 3loqA-2o9aA:
undetectable		 3loqA-2o9aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 6 VAL A 172
VAL A  26
ILE A 153
PHE A 161
 None
 1.07A 5jw1B-2o9aA:
undetectable		 5jw1B-2o9aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 6 LEU A  72
LEU A  75
SER A  76
THR A  81
 None
 1.23A 5l4iB-2o9aA:
undetectable		 5l4iB-2o9aA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 8 VAL A  26
ILE A  14
LEU A  15
ILE A 133
SER A 116
 None
 1.14A 5numA-2o9aA:
undetectable		 5numA-2o9aA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
MET A  62
PHE A 117
THR A 110
 PYR  A 905 (-3.2A)
None
None
None
EDO  A 901 (-4.6A)
 1.37A 5yf0A-2o9aA:
undetectable		 5yf0A-2o9aA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 4 ALA A  67
ALA A 130
ALA A 143
ALA A  29
 PYR  A 905 (-4.0A)
PYR  A 905 ( 4.9A)
None
None
 0.79A 6gtqA-2o9aA:
0.5
6gtqB-2o9aA:
0.2		 6gtqA-2o9aA:
18.23
6gtqB-2o9aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2o9a ACETATE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 4 ALA A 143
ALA A  29
ALA A  67
ALA A 130
 None
None
PYR  A 905 (-4.0A)
PYR  A 905 ( 4.9A)
 0.81A 6gtqA-2o9aA:
0.5
6gtqB-2o9aA:
0.2		 6gtqA-2o9aA:
18.23
6gtqB-2o9aA:
18.23