SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		5 / 10 GLY A 175
HIS A 181
ALA A 194
ALA A 195
ILE A 198
 None
TCB  A 500 ( 4.6A)
None
None
None
 0.98A 1likA-2o9rA:
undetectable		 1likA-2o9rA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		3 / 3 ASN A 163
ILE A 115
MET A  13
 None
 0.74A 2h42C-2o9rA:
undetectable		 2h42C-2o9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 8 ILE A 342
PHE A 256
GLY A 294
ILE A 354
 None
 0.99A 2qwxA-2o9rA:
undetectable
2qwxB-2o9rA:
undetectable		 2qwxA-2o9rA:
19.56
2qwxB-2o9rA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 7 ILE A 352
LEU A 396
PHE A 389
ARG A 341
 None
 1.22A 2zxwN-2o9rA:
undetectable
2zxwW-2o9rA:
undetectable		 2zxwN-2o9rA:
20.38
2zxwW-2o9rA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 4 THR A  39
VAL A  47
GLY A 179
THR A 178
 None
 1.03A 3cflA-2o9rA:
undetectable		 3cflA-2o9rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		5 / 9 PHE A 251
TYR A 169
ALA A 195
ALA A 191
LEU A 311
 None
 1.46A 3l4dB-2o9rA:
undetectable		 3l4dB-2o9rA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		5 / 9 PHE A 251
TYR A 169
ALA A 195
ALA A 191
LEU A 311
 None
 1.50A 3l4dC-2o9rA:
undetectable		 3l4dC-2o9rA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 7 TYR A 297
ASN A 248
LEU A 293
LEU A 338
 None
 1.29A 3nk2X-2o9rA:
undetectable		 3nk2X-2o9rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		5 / 10 ILE A  36
GLY A 175
TYR A 176
GLU A 190
GLY A 179
 None
 1.20A 4bwlC-2o9rA:
10.5		 4bwlC-2o9rA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		5 / 12 LEU A 111
ALA A 112
LEU A  76
LEU A 114
ILE A 115
 None
 1.02A 4dm8B-2o9rA:
undetectable		 4dm8B-2o9rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 5 HIS A  62
THR A 427
GLU A 429
HIS A 422
 None
 1.46A 4hvcB-2o9rA:
undetectable		 4hvcB-2o9rA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		3 / 3 ASP A 124
TRP A 402
SER A  81
 None
TCB  A 500 ( 3.6A)
None
 0.93A 4lrhB-2o9rA:
undetectable		 4lrhB-2o9rA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		3 / 3 ASP A 124
TRP A 402
SER A  81
 None
TCB  A 500 ( 3.6A)
None
 1.01A 4lrhF-2o9rA:
undetectable		 4lrhF-2o9rA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 8 GLY A 419
THR A  16
LEU A  73
PHE A 404
 None
 0.96A 4m5mA-2o9rA:
undetectable		 4m5mA-2o9rA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 7 GLU A 225
SER A 301
ILE A 303
VAL A 314
 None
 1.16A 4tvtA-2o9rA:
undetectable		 4tvtA-2o9rA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		3 / 3 ASN A 166
PHE A 400
TYR A  78
 None
 0.65A 4u15A-2o9rA:
undetectable		 4u15A-2o9rA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 8 ALA A 252
PRO A 289
LEU A 293
LEU A 350
 None
 1.02A 5dzkF-2o9rA:
1.6
5dzkT-2o9rA:
undetectable		 5dzkF-2o9rA:
19.64
5dzkT-2o9rA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		4 / 8 ASN A 357
TRP A 438
PHE A 439
THR A 324
 None
 1.30A 5hqaA-2o9rA:
7.6		 5hqaA-2o9rA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2o9r BETA-GLUCOSIDASE B
(Paenibacillus
polymyxa) 		5 / 12 PRO A  34
GLY A  30
ASP A  58
GLY A  25
ALA A  83
 None
 1.00A 6nj9K-2o9rA:
undetectable		 6nj9K-2o9rA:
20.75