SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 8 GLY A  28
GLU A 134
SER A 132
HIS A  25
 None
 0.91A 1ax9A-2oasA:
undetectable		 1ax9A-2oasA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 6 LEU A  53
LEU A  50
ILE A 111
GLU A 134
 None
 1.05A 1mt1A-2oasA:
undetectable
1mt1F-2oasA:
undetectable		 1mt1A-2oasA:
9.70
1mt1F-2oasA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 6 PHE A 264
ALA A 265
LEU A 266
ILE A 211
 None
 1.05A 1sbrA-2oasA:
undetectable
1sbrB-2oasA:
undetectable		 1sbrA-2oasA:
19.63
1sbrB-2oasA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 7 GLY A  28
GLU A 134
SER A 132
HIS A  25
 None
 0.89A 2ackA-2oasA:
undetectable		 2ackA-2oasA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		3 / 3 LEU A 207
MET A 209
MET A 284
 None
 0.95A 2vavF-2oasA:
undetectable		 2vavF-2oasA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 7 VAL A 384
THR A 385
ILE A 193
ILE A 214
 None
 0.86A 3deuA-2oasA:
undetectable		 3deuA-2oasA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		6 / 10 ALA A 350
VAL A 197
ILE A 304
GLY A 210
ILE A 211
ALA A 217
 None
 1.16A 3t3cB-2oasA:
undetectable		 3t3cB-2oasA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		5 / 12 PHE A  76
LEU A 219
ASP A 216
GLY A 212
ILE A 211
 COA  A 501 (-4.5A)
None
None
None
None
 1.44A 4djeA-2oasA:
undetectable		 4djeA-2oasA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		3 / 3 TYR A 387
HIS A 409
ARG A 413
 None
 1.16A 4e7bC-2oasA:
undetectable		 4e7bC-2oasA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		5 / 12 GLY A 130
GLY A  28
ALA A  29
ILE A 180
SER A 182
 None
 1.03A 4rtmA-2oasA:
2.4		 4rtmA-2oasA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 7 THR A 136
ARG A 167
ALA A 114
ILE A 146
 None
 0.97A 4txnC-2oasA:
undetectable		 4txnC-2oasA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		3 / 3 SER A 128
ASP A 237
ASP A 276
 None
 0.65A 4uckA-2oasA:
undetectable		 4uckA-2oasA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 5 ILE A 193
LEU A 404
HIS A 381
VAL A 348
 None
 1.15A 5jmnB-2oasA:
undetectable		 5jmnB-2oasA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 7 VAL A 118
ILE A 116
VAL A 171
ALA A 148
 None
 0.73A 5ospA-2oasA:
undetectable		 5ospA-2oasA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 7 VAL A 118
ILE A 116
VAL A 171
ALA A 148
 None
 0.76A 5osrA-2oasA:
undetectable		 5osrA-2oasA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 5 LEU A 397
ALA A 401
LEU A 404
LEU A 428
 None
 0.76A 5vkqA-2oasA:
undetectable
5vkqD-2oasA:
undetectable		 5vkqA-2oasA:
13.71
5vkqD-2oasA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 5 LEU A 428
LEU A 397
ALA A 401
LEU A 404
 None
 0.77A 5vkqA-2oasA:
undetectable
5vkqB-2oasA:
undetectable		 5vkqA-2oasA:
13.71
5vkqB-2oasA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 5 LEU A 428
LEU A 397
ALA A 401
LEU A 404
 None
 0.75A 5vkqB-2oasA:
undetectable
5vkqC-2oasA:
undetectable		 5vkqB-2oasA:
13.71
5vkqC-2oasA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		4 / 5 LEU A 428
LEU A 397
ALA A 401
LEU A 404
 None
 0.81A 5vkqC-2oasA:
undetectable
5vkqD-2oasA:
undetectable		 5vkqC-2oasA:
13.71
5vkqD-2oasA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		5 / 12 GLY A 263
LEU A 219
GLY A 210
PHE A 335
ILE A 211
 None
 1.15A 5vooA-2oasA:
undetectable		 5vooA-2oasA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE
(Shewanella
oneidensis) 		5 / 12 GLY A  57
ILE A 214
GLY A 210
PHE A 183
THR A  55
 None
 1.17A 6e8qA-2oasA:
undetectable		 6e8qA-2oasA:
12.26