SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ob1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  84
TYR A  79
ILE A 294
GLU A 298
 None
 0.79A 1mrjA-2ob1A:
undetectable		 1mrjA-2ob1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 126
LEU A 176
ALA A 172
LEU A 171
 None
 0.96A 1nh8A-2ob1A:
undetectable		 1nh8A-2ob1A:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
GLY A 107
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.26A 1rjdA-2ob1A:
53.6		 1rjdA-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
SER A 132
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.66A 1rjdA-2ob1A:
53.6		 1rjdA-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 6 ARG A  81
ASP A 128
ASP A 175
ASN A 177
GLU A 201
 None
 0.37A 1rjdA-2ob1A:
53.6		 1rjdA-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
GLY A 107
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.26A 1rjdB-2ob1A:
53.0		 1rjdB-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
SER A 132
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.66A 1rjdB-2ob1A:
53.0		 1rjdB-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 6 ARG A  81
ASP A 128
ASP A 175
ASN A 177
GLU A 201
 None
 0.38A 1rjdB-2ob1A:
53.0		 1rjdB-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
GLY A 107
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.23A 1rjdC-2ob1A:
52.8		 1rjdC-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
SER A 132
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.66A 1rjdC-2ob1A:
52.8		 1rjdC-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 6 ARG A  81
ASP A 128
ASP A 175
ASN A 177
GLU A 201
 None
 0.44A 1rjdC-2ob1A:
52.8		 1rjdC-2ob1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 254
ASP A  11
CYH A  15
 None
 1.12A 2br4E-2ob1A:
9.1		 2br4E-2ob1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 111
ASP A 128
ASP A 175
 PO4  A2001 (-3.4A)
None
None
 0.73A 2ejtA-2ob1A:
9.1		 2ejtA-2ob1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 107
ASP A 128
ASP A 175
LEU A 176
 None
 0.70A 2uyqA-2ob1A:
22.9		 2uyqA-2ob1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 GLY A 105
GLY A 107
ASP A 109
LEU A 176
ASN A 177
TYR A 206
MET A 207
 None
None
PO4  A2001 (-3.1A)
None
None
None
None
 0.68A 2zw9A-2ob1A:
31.1		 2zw9A-2ob1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A  81
ASP A 128
ASP A 175
GLU A 201
 None
 0.52A 2zw9A-2ob1A:
31.1		 2zw9A-2ob1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		9 / 12 GLY A 105
GLY A 107
ASP A 109
ASP A 175
LEU A 176
ASN A 177
GLU A 201
TYR A 206
MET A 207
 None
None
PO4  A2001 (-3.1A)
None
None
None
None
None
None
 0.73A 2zw9B-2ob1A:
7.8		 2zw9B-2ob1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 203
GLY A 105
GLY A 107
SER A 108
ILE A 127
 None
 1.03A 3cjtG-2ob1A:
10.2		 3cjtG-2ob1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 203
GLY A 105
GLY A 107
SER A 108
ILE A 127
 None
 1.01A 3cjtO-2ob1A:
10.0		 3cjtO-2ob1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 190
ARG A 168
ILE A 219
PHE A 223
VAL A 101
 None
 1.39A 3ijdB-2ob1A:
0.7		 3ijdB-2ob1A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  12
GLY A 105
GLY A 107
ASP A 175
LEU A 176
GLU A 201
CYH A 202
 None
 0.51A 3o7wA-2ob1A:
30.8		 3o7wA-2ob1A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  12
GLY A 105
GLY A 107
GLU A 201
CYH A 202
TYR A 206
 None
 0.60A 3o7wA-2ob1A:
30.8		 3o7wA-2ob1A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 107
ASP A 128
ASP A 175
 None
 0.43A 3ou7C-2ob1A:
11.2		 3ou7C-2ob1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 113
TYR A 124
TYR A 169
LEU A 140
 None
 1.13A 4b3qA-2ob1A:
undetectable		 4b3qA-2ob1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 111
GLU A 201
ASN A 103
 PO4  A2001 (-3.4A)
None
None
 0.78A 4imaD-2ob1A:
3.5		 4imaD-2ob1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 111
GLU A 201
ASN A 103
 PO4  A2001 (-3.4A)
None
None
 0.77A 4ip7D-2ob1A:
undetectable		 4ip7D-2ob1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 213
THR A 182
LEU A 203
LEU A 204
 None
 1.03A 4lvcB-2ob1A:
2.9		 4lvcB-2ob1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 223
ILE A 127
ALA A 123
VAL A 102
VAL A 125
 None
 0.92A 4nkxB-2ob1A:
undetectable		 4nkxB-2ob1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  73
PHE A 243
MET A 317
LEU A 262
LEU A 251
 None
 1.43A 4o8fB-2ob1A:
undetectable		 4o8fB-2ob1A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 214
LEU A 215
GLU A 211
ASN A 177
 None
 0.96A 4ww7A-2ob1A:
undetectable		 4ww7A-2ob1A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 230
TYR A 271
TYR A 231
GLU A 201
 None
 1.10A 5aclA-2ob1A:
undetectable		 5aclA-2ob1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  49
LEU A  13
ARG A 141
 None
 0.40A 5hnzB-2ob1A:
undetectable		 5hnzB-2ob1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 306
VAL A  22
LEU A  25
TYR A 231
GLY A  77
 None
 1.34A 5i8fA-2ob1A:
undetectable		 5i8fA-2ob1A:
18.27