SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 1jffB-2obaA:
undetectable		 1jffB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  52
PHE A   7
LEU A  93
MET A   1
 None
 1.08A 1wrlE-2obaA:
undetectable		 1wrlE-2obaA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 HIS A  13
HIS A  28
HIS A  30
THR A  81
GLU A  83
GLU A 107
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
None
None
ZN  A 200 (-3.1A)
 0.57A 2dttA-2obaA:
15.5
2dttC-2obaA:
15.4		 2dttA-2obaA:
32.86
2dttC-2obaA:
32.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 HIS A  13
HIS A  28
HIS A  30
THR A  81
GLU A  83
GLU A 107
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
None
None
ZN  A 200 (-3.1A)
 0.79A 2dttD-2obaA:
15.3
2dttF-2obaA:
15.4		 2dttD-2obaA:
32.86
2dttF-2obaA:
32.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 11 HIS A  13
HIS A  28
HIS A  30
THR A  81
GLU A  83
GLU A 107
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
None
None
ZN  A 200 (-3.1A)
 0.55A 2dttD-2obaA:
15.3
2dttE-2obaA:
16.4		 2dttD-2obaA:
32.86
2dttE-2obaA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 2hxfB-2obaA:
undetectable		 2hxfB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 2hxhB-2obaA:
undetectable		 2hxhB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_E_CUE801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  15
HIS A  30
HIS A  13
HIS A  28
 None
ZN  A 200 (-3.4A)
ZN  A 200 (-3.6A)
ZN  A 200 (-3.6A)
 1.32A 2oqeE-2obaA:
0.0		 2oqeE-2obaA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 2p4nB-2obaA:
undetectable		 2p4nB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 2wbeB-2obaA:
undetectable		 2wbeB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 3dcoB-2obaA:
undetectable		 3dcoB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.07A 3edlB-2obaA:
undetectable		 3edlB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.04A 3iz0B-2obaA:
undetectable		 3iz0B-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.04A 5hnwB-2obaA:
undetectable		 5hnwB-2obaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.05A 5hnyB-2obaA:
undetectable		 5hnyB-2obaA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  93
LYS A   5
GLU A   2
LEU A   3
GLU A  99
 None
 1.30A 5nwvA-2obaA:
undetectable		 5nwvA-2obaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A  13
HIS A  30
HIS A  28
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
ZN  A 200 (-3.6A)
 0.61A 5zrdA-2obaA:
undetectable		 5zrdA-2obaA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A  28
HIS A  13
HIS A  30
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
 0.55A 5zrdA-2obaA:
undetectable		 5zrdA-2obaA:
13.58