SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2obi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 8 VAL A  42
PHE A 138
THR A 139
LYS A  48
 None
 1.18A 2kotB-2obiA:
undetectable		 2kotB-2obiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		5 / 11 VAL A 149
GLY A 126
ARG A 152
THR A 139
ILE A 134
 None
 1.27A 3bf1A-2obiA:
undetectable
3bf1B-2obiA:
undetectable		 3bf1A-2obiA:
20.56
3bf1B-2obiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 7 PHE A  92
ASN A  76
ALA A  43
THR A  49
 None
 0.82A 3t3sC-2obiA:
undetectable		 3t3sC-2obiA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 8 PHE A  92
ASN A  76
ALA A  43
THR A  49
 None
 0.85A 3t3sE-2obiA:
undetectable		 3t3sE-2obiA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 8 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 1.02A 4d33A-2obiA:
undetectable		 4d33A-2obiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 7 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 0.98A 4d33B-2obiA:
undetectable		 4d33B-2obiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 8 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 1.03A 4d39A-2obiA:
undetectable		 4d39A-2obiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		4 / 7 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 1.07A 4d39B-2obiA:
undetectable		 4d39B-2obiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		5 / 12 VAL A 149
GLY A 126
ARG A 152
THR A 139
ILE A 134
 None
 1.28A 4o5fA-2obiA:
undetectable
4o5fB-2obiA:
undetectable		 4o5fA-2obiA:
20.70
4o5fB-2obiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		5 / 12 VAL A 149
GLY A 126
ARG A 152
THR A 139
ILE A 134
 None
 1.26A 4o5fA-2obiA:
undetectable
4o5fB-2obiA:
undetectable		 4o5fA-2obiA:
20.70
4o5fB-2obiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)
(Homo
sapiens) 		5 / 12 VAL A 149
GLY A 126
ARG A 152
THR A 139
ILE A 134
 None
 1.26A 5b8hA-2obiA:
undetectable
5b8hB-2obiA:
undetectable		 5b8hA-2obiA:
20.89
5b8hB-2obiA:
20.89