SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2obm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2obm ESCN
(Escherichia
coli) 		3 / 3 GLN A 425
HIS A 354
PRO A 356
 None
None
ADP  A 600 ( 4.2A)
 0.98A 1d8cA-2obmA:
undetectable		 1d8cA-2obmA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2obm ESCN
(Escherichia
coli) 		5 / 12 ALA A 160
ILE A 169
THR A 315
LEU A 262
LEU A 186
 None
 1.37A 1eiiA-2obmA:
undetectable		 1eiiA-2obmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2obm ESCN
(Escherichia
coli) 		4 / 8 PHE A 254
TYR A 253
ILE A 250
VAL A 227
 None
 0.86A 1fslA-2obmA:
undetectable		 1fslA-2obmA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2obm ESCN
(Escherichia
coli) 		5 / 11 LEU A 299
ALA A 274
ALA A 272
VAL A 335
LEU A 339
 None
 1.17A 1rlbF-2obmA:
undetectable		 1rlbF-2obmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2obm ESCN
(Escherichia
coli) 		5 / 12 LEU A 218
LEU A 215
LEU A 201
MET A 264
THR A 428
 None
None
None
None
ADP  A 600 (-4.5A)
 1.37A 2aa6A-2obmA:
undetectable		 2aa6A-2obmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2obm ESCN
(Escherichia
coli) 		4 / 8 LEU A 186
ILE A 161
ILE A 175
ILE A 173
 None
 0.72A 2bu8A-2obmA:
undetectable		 2bu8A-2obmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2obm ESCN
(Escherichia
coli) 		5 / 9 GLY A 188
LEU A 215
LEU A 203
ASP A 266
GLU A 206
 None
 1.13A 2j2pB-2obmA:
undetectable
2j2pC-2obmA:
undetectable		 2j2pB-2obmA:
20.73
2j2pC-2obmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2obm ESCN
(Escherichia
coli) 		5 / 12 LEU A 345
ILE A 175
LEU A 441
VAL A 444
VAL A 158
 None
 1.09A 2pnjA-2obmA:
2.4		 2pnjA-2obmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 2obm ESCN
(Escherichia
coli) 		5 / 11 GLY A 193
ALA A 194
ILE A 343
ILE A 161
ASP A 162
 None
 0.94A 4dt8A-2obmA:
undetectable		 4dt8A-2obmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2obm ESCN
(Escherichia
coli) 		5 / 10 GLY A 193
ALA A 194
ILE A 343
ILE A 161
ASP A 162
 None
 1.00A 4dt8B-2obmA:
undetectable		 4dt8B-2obmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2obm ESCN
(Escherichia
coli) 		4 / 8 ASP A 286
VAL A 295
GLY A 279
ALA A 272
 None
 0.90A 4m48A-2obmA:
undetectable		 4m48A-2obmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2obm ESCN
(Escherichia
coli) 		3 / 3 ALA A 196
GLN A 171
GLY A 341
 None
 0.63A 4odoC-2obmA:
undetectable		 4odoC-2obmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2obm ESCN
(Escherichia
coli) 		5 / 12 LEU A 362
GLY A 361
LEU A 165
ARG A 336
ILE A 424
 None
 1.34A 4okbA-2obmA:
undetectable		 4okbA-2obmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2obm ESCN
(Escherichia
coli) 		3 / 3 PRO A 308
VAL A 367
HIS A 369
 None
 0.84A 4pevC-2obmA:
undetectable		 4pevC-2obmA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2obm ESCN
(Escherichia
coli) 		5 / 11 VAL A 445
VAL A 444
ILE A 360
ILE A 424
LEU A 441
 None
 1.09A 5e4dB-2obmA:
undetectable		 5e4dB-2obmA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2obm ESCN
(Escherichia
coli) 		5 / 12 LEU A 156
THR A 319
ILE A 175
LEU A 186
PRO A 356
 None
None
None
None
ADP  A 600 ( 4.2A)
 1.09A 5eajB-2obmA:
undetectable		 5eajB-2obmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2obm ESCN
(Escherichia
coli) 		5 / 9 LEU A 218
LEU A 187
ILE A 190
PRO A 356
LEU A 186
 None
None
None
ADP  A 600 ( 4.2A)
None
 1.43A 5g48B-2obmA:
undetectable		 5g48B-2obmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2obm ESCN
(Escherichia
coli) 		3 / 3 LYS A 436
GLN A 425
ASN A 422
 None
 0.82A 5l2tA-2obmA:
undetectable		 5l2tA-2obmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2obm ESCN
(Escherichia
coli) 		4 / 4 GLU A 123
PRO A 121
ILE A 115
LEU A 114
 None
 1.21A 5m45A-2obmA:
undetectable		 5m45A-2obmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2obm ESCN
(Escherichia
coli) 		4 / 4 GLU A 123
PRO A 121
ILE A 115
LEU A 114
 None
 1.15A 5m45D-2obmA:
undetectable		 5m45D-2obmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2obm ESCN
(Escherichia
coli) 		4 / 4 GLU A 123
PRO A 121
ILE A 115
LEU A 114
 None
 1.20A 5m45G-2obmA:
undetectable		 5m45G-2obmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2obm ESCN
(Escherichia
coli) 		4 / 4 GLU A 123
PRO A 121
ILE A 115
LEU A 114
 None
 1.17A 5m45J-2obmA:
undetectable		 5m45J-2obmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2obm ESCN
(Escherichia
coli) 		5 / 9 LEU A 303
LEU A 299
ILE A 204
LEU A 263
ALA A 275
 None
 1.19A 5og9A-2obmA:
undetectable		 5og9A-2obmA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 2obm ESCN
(Escherichia
coli) 		5 / 12 ALA A 177
GLY A 178
SER A 179
ARG A 270
ASP A 266
 None
 1.20A 5w7pA-2obmA:
3.2		 5w7pA-2obmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2obm ESCN
(Escherichia
coli) 		3 / 3 THR A 389
ALA A 413
LYS A 415
 None
 0.61A 6fgcA-2obmA:
undetectable		 6fgcA-2obmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2obm ESCN
(Escherichia
coli) 		3 / 3 THR A 389
ALA A 413
LYS A 415
 None
 0.61A 6fgdA-2obmA:
undetectable		 6fgdA-2obmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2obm ESCN
(Escherichia
coli) 		4 / 6 LEU A 339
VAL A 229
PHE A 176
GLY A 332
 None
 0.98A 6hd4B-2obmA:
undetectable		 6hd4B-2obmA:
11.99