SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2obx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 7 LEU A 111
ALA A  73
LEU A  75
VAL A  12
 None
 0.71A 1tyrB-2obxA:
undetectable		 1tyrB-2obxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 7 LEU A  75
GLY A  41
ILE A  40
ILE A  14
 None
 0.75A 2aojB-2obxA:
undetectable		 2aojB-2obxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		5 / 12 LEU A  75
GLY A  42
GLY A  41
ILE A  40
ILE A  14
 None
 1.00A 2r5pA-2obxA:
undetectable		 2r5pA-2obxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		5 / 12 LEU A  75
GLY A  42
GLY A  41
ILE A  40
ILE A  14
 None
 1.00A 2r5pC-2obxA:
undetectable		 2r5pC-2obxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 7 LEU A 111
ALA A  73
LEU A  75
VAL A  12
 None
 0.85A 3d2tA-2obxA:
undetectable		 3d2tA-2obxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 7 HIS A  22
ILE A  25
PRO A 117
HIS A 126
 INI  A 201 ( 4.9A)
None
None
None
 1.04A 4g5jA-2obxA:
undetectable		 4g5jA-2obxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 8 LEU A 111
ALA A  73
LEU A  75
VAL A  12
 None
 0.78A 4iizB-2obxA:
undetectable		 4iizB-2obxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 8 LEU A 111
ALA A  73
LEU A  75
VAL A  12
 None
 0.82A 4ik6B-2obxA:
undetectable		 4ik6B-2obxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 5 LEU A 111
ALA A  73
LEU A  75
VAL A  12
 None
 0.86A 5cr1A-2obxA:
undetectable		 5cr1A-2obxA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 8 ALA A  55
HIS A  22
HIS A  88
THR A 116
 INI  A 201 (-3.4A)
INI  A 201 ( 4.9A)
None
None
 1.30A 5db5A-2obxA:
undetectable
5db5B-2obxA:
undetectable		 5db5A-2obxA:
18.70
5db5B-2obxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		5 / 8 VAL A  52
THR A  77
VAL A  16
PHE A  50
VAL A  17
 None
 1.39A 5l94A-2obxA:
undetectable		 5l94A-2obxA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 8 PRO A  59
ILE A  96
VAL A 114
TYR A  56
 None
None
None
INI  A 201 (-4.7A)
 0.85A 5mzrE-2obxA:
2.4		 5mzrE-2obxA:
18.35