SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		4 / 8 ALA A 237
GLY A 257
ILE A 132
ILE A 242
 None
 0.70A 1d4yB-2ocaA:
undetectable		 1d4yB-2ocaA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 12 ALA A 423
LEU A 454
LEU A 339
ALA A 350
ILE A 363
 None
 1.24A 1g5yB-2ocaA:
undetectable		 1g5yB-2ocaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 8 ALA A 237
GLY A 257
ILE A 132
ILE A 246
ILE A 242
 None
 1.48A 1hshD-2ocaA:
undetectable		 1hshD-2ocaA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 8 ALA A 267
ILE A  51
PRO A  61
ILE A 246
ILE A 242
 None
 1.45A 1hshD-2ocaA:
undetectable		 1hshD-2ocaA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 ASP A 232
LEU A 135
LEU A 258
 None
 0.68A 1ikeA-2ocaA:
undetectable		 1ikeA-2ocaA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		4 / 8 PHE A  10
GLU A  87
TYR A 156
TYR A 152
 None
 1.37A 2aoxA-2ocaA:
3.7		 2aoxA-2ocaA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 11 ILE A  68
ILE A   3
HIS A   6
GLY A  63
LEU A  54
 None
 1.20A 2azyA-2ocaA:
undetectable		 2azyA-2ocaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 11 ILE A  68
ILE A   3
HIS A   6
GLY A 274
LEU A  54
 None
 0.99A 2azyA-2ocaA:
undetectable		 2azyA-2ocaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		4 / 8 ALA A 174
ALA A 146
ARG A 150
LEU A 143
 None
 0.82A 2bxmA-2ocaA:
undetectable		 2bxmA-2ocaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 SER A  20
ASP A  16
ASP A   2
 None
 0.79A 2plwA-2ocaA:
undetectable		 2plwA-2ocaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		4 / 6 ILE A 144
ILE A 188
LEU A 133
MET A 230
 None
 0.98A 3adsA-2ocaA:
undetectable		 3adsA-2ocaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		4 / 7 ILE A 144
ILE A 188
LEU A 133
MET A 230
 None
 0.98A 3adxA-2ocaA:
undetectable		 3adxA-2ocaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 11 ARG A 150
VAL A 164
PRO A 165
ILE A 160
ILE A 188
 None
 1.45A 3ganA-2ocaA:
0.0		 3ganA-2ocaA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 ILE A  15
PHE A  22
HIS A  12
 None
 0.74A 3h0aA-2ocaA:
undetectable		 3h0aA-2ocaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 9 THR A  21
GLU A  19
LEU A  25
LEU A  54
ILE A  15
 None
 1.34A 3nbqA-2ocaA:
undetectable		 3nbqA-2ocaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 ARG A 441
LEU A 297
THR A 285
 None
 0.88A 3oxcA-2ocaA:
undetectable		 3oxcA-2ocaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 SER A 261
ASP A 232
ASP A 176
 None
 0.86A 3uj7A-2ocaA:
undetectable		 3uj7A-2ocaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 PRO A  61
LEU A  60
GLN A  67
 None
 0.70A 4pevB-2ocaA:
2.7		 4pevB-2ocaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		6 / 12 ILE A 482
ILE A 430
VAL A 432
LEU A 433
VAL A 451
ILE A 299
 None
 1.26A 5mueA-2ocaA:
undetectable		 5mueA-2ocaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 LYS A 355
HIS A 424
HIS A 356
 None
 1.14A 5oexA-2ocaA:
undetectable		 5oexA-2ocaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 LYS A 355
HIS A 424
HIS A 356
 None
 1.15A 5oexB-2ocaA:
undetectable		 5oexB-2ocaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 LYS A 355
HIS A 424
HIS A 356
 None
 1.16A 5oexC-2ocaA:
undetectable		 5oexC-2ocaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 LYS A 355
HIS A 424
HIS A 356
 None
 1.15A 5oexD-2ocaA:
undetectable		 5oexD-2ocaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		5 / 10 MET A 353
PHE A 351
ALA A 449
LEU A 417
ALA A 350
 None
 1.45A 5oy0b-2ocaA:
undetectable		 5oy0b-2ocaA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2oca ATP-DEPENDENT DNA
HELICASE UVSW
(Escherichia
virus
T4) 		4 / 8 GLU A 113
PHE A 183
PHE A 177
MET A 173
 None
 1.10A 5y2tB-2ocaA:
undetectable		 5y2tB-2ocaA:
undetectable