SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ocz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		5 / 12 VAL A   4
TYR A 198
TYR A  92
ILE A 114
LEU A  28
 None
 1.12A 1z9hA-2oczA:
undetectable		 1z9hA-2oczA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		5 / 12 VAL A   4
TYR A 198
TYR A  92
ILE A 114
LEU A  28
 None
 1.11A 1z9hB-2oczA:
undetectable		 1z9hB-2oczA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		5 / 12 VAL A   4
TYR A 198
TYR A  92
ILE A 114
LEU A  28
 None
 1.13A 1z9hC-2oczA:
undetectable		 1z9hC-2oczA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		5 / 12 VAL A   4
TYR A 198
TYR A  92
ILE A 114
LEU A  28
 None
 1.11A 1z9hD-2oczA:
undetectable		 1z9hD-2oczA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		5 / 11 GLN A 171
VAL A 141
MET A 134
SER A 116
ASP A  94
 None
 1.49A 2c12B-2oczA:
undetectable		 2c12B-2oczA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		5 / 12 SER A 116
MET A 178
ILE A 176
PHE A 120
LEU A  61
 None
EDO  A 503 ( 4.3A)
None
None
None
 1.41A 3aocC-2oczA:
undetectable		 3aocC-2oczA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		4 / 4 ARG A 162
ASP A 153
GLY A 182
THR A 175
 None
 1.47A 3k4vB-2oczA:
undetectable		 3k4vB-2oczA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		4 / 6 PRO A   6
ILE A  48
TYR A  23
PHE A  52
 None
 0.89A 4g10A-2oczA:
undetectable		 4g10A-2oczA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		4 / 7 VAL A 199
ALA A   5
LYS A  55
TYR A  92
 None
 1.07A 4lb2A-2oczA:
undetectable		 4lb2A-2oczA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		4 / 4 ILE A  81
ARG A  62
TYR A  77
GLU A  96
 None
 1.30A 4zzbD-2oczA:
undetectable		 4zzbD-2oczA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ocz 3-DEHYDROQUINATE
DEHYDRATASE
(Streptococcus
pyogenes) 		4 / 6 VAL A   4
TYR A 198
ILE A 114
ASP A  94
 None
 1.26A 5iwuA-2oczA:
undetectable		 5iwuA-2oczA:
23.99