SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2odh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		5 / 12 ILE A 134
ALA A 128
LEU A 148
LEU A 230
ILE A 185
 None
None
ACT  A 239 (-4.5A)
None
None
 1.16A 1xzxX-2odhA:
undetectable		 1xzxX-2odhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		5 / 12 LEU A  75
ILE A 153
ILE A 185
THR A 189
LEU A 191
 None
 1.03A 2bdmA-2odhA:
undetectable		 2bdmA-2odhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		4 / 8 LEU A 148
ILE A 153
ILE A 188
ILE A 185
 ACT  A 239 (-4.5A)
None
None
None
 0.81A 2bu8A-2odhA:
undetectable		 2bu8A-2odhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		4 / 8 LEU A 227
ILE A 222
LEU A  73
LEU A 182
 PEG  A 240 ( 4.8A)
None
None
None
 0.60A 2xfhA-2odhA:
undetectable		 2xfhA-2odhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		5 / 12 ILE A 134
ALA A 128
LEU A 148
LEU A 230
ILE A 185
 None
None
ACT  A 239 (-4.5A)
None
None
 1.05A 3uvvA-2odhA:
undetectable		 3uvvA-2odhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		4 / 8 LEU A  61
VAL A  46
LEU A 237
LEU A  13
 None
 0.77A 4l1xA-2odhA:
undetectable		 4l1xA-2odhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		4 / 6 ILE A 188
ILE A 234
ILE A 153
LEU A 197
 None
PEG  A 240 ( 4.4A)
None
None
 0.59A 4o8fB-2odhA:
undetectable		 4o8fB-2odhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		5 / 10 LEU A 227
LEU A 182
VAL A 159
LEU A  13
VAL A   9
 PEG  A 240 ( 4.8A)
None
None
None
None
 1.20A 4po0A-2odhA:
undetectable		 4po0A-2odhA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		3 / 3 PHE A  93
ILE A  89
ASP A 200
 None
 0.72A 5cswB-2odhA:
undetectable		 5cswB-2odhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2odh R.BCNI
(Brevibacillus
centrosporus) 		4 / 8 LEU A 237
GLU A   8
LEU A  53
ILE A  51
 None
 1.00A 5mzjA-2odhA:
undetectable		 5mzjA-2odhA:
16.98