SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 196
VAL A 108
ALA A 115
CYH A 112
 None
 1.07A 1mz9D-2oerA:
undetectable		 1mz9D-2oerA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  79
ARG A  83
ARG A  80
 None
 1.16A 2jb7A-2oerA:
undetectable
2jb7B-2oerA:
undetectable
2jb7C-2oerA:
undetectable		 2jb7A-2oerA:
21.82
2jb7B-2oerA:
21.82
2jb7C-2oerA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
ARG A  79
ARG A  83
 None
 1.16A 2jb7A-2oerA:
undetectable
2jb7B-2oerA:
undetectable
2jb7C-2oerA:
undetectable		 2jb7A-2oerA:
21.82
2jb7B-2oerA:
21.82
2jb7C-2oerA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  83
ARG A  80
ARG A  79
 None
 1.13A 2jb7A-2oerA:
undetectable
2jb7B-2oerA:
undetectable
2jb7C-2oerA:
undetectable		 2jb7A-2oerA:
21.82
2jb7B-2oerA:
21.82
2jb7C-2oerA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 SER A  75
GLN A  74
PHE A  71
 None
 0.78A 3g4lC-2oerA:
undetectable		 3g4lC-2oerA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  23
GLY A  53
ALA A  52
ILE A  56
ILE A  27
 None
 0.86A 3nu3B-2oerA:
undetectable		 3nu3B-2oerA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  23
GLY A  53
ALA A  52
ILE A  56
ILE A  27
 None
 0.88A 3nu4B-2oerA:
undetectable		 3nu4B-2oerA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  23
GLY A  53
ALA A  52
ILE A  56
ILE A  27
 None
 0.89A 3nuoB-2oerA:
undetectable		 3nuoB-2oerA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 ARG A  51
ILE A  69
PHE A  43
LEU A  73
 None
 0.77A 4mmcA-2oerA:
1.6		 4mmcA-2oerA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  23
GLY A  53
ALA A  52
ILE A  56
ILE A  27
 None
 0.82A 4rvjB-2oerA:
undetectable		 4rvjB-2oerA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  23
GLY A  53
ALA A  52
ILE A  56
ILE A  27
 None
 0.82A 4rvjD-2oerA:
undetectable		 4rvjD-2oerA:
19.00