SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  93
ILE A  78
ILE A  75
SER A 121
LEU A  21
 None
 1.10A 1xdkB-2oewA:
undetectable		 1xdkB-2oewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 291
ARG A 290
PHE A 242
VAL A 295
 None
 1.10A 2fl5E-2oewA:
undetectable
2fl5F-2oewA:
undetectable		 2fl5E-2oewA:
20.90
2fl5F-2oewA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 170
THR A 166
ALA A 159
ALA A 128
ILE A 179
 None
 1.15A 2nyrA-2oewA:
undetectable		 2nyrA-2oewA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 PRO A  83
PHE A 355
LYS A  81
 None
 1.16A 3bjwG-2oewA:
1.1		 3bjwG-2oewA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A  59
LEU A  58
GLN A   8
 None
 0.81A 3g4lA-2oewA:
undetectable		 3g4lA-2oewA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 6 VAL A 343
SER A 188
ILE A 190
ALA A 128
LEU A 124
 None
 1.32A 3kk6B-2oewA:
undetectable		 3kk6B-2oewA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  65
LEU A 124
ILE A 347
THR A 341
ALA A 128
 None
 0.92A 3mdvB-2oewA:
undetectable		 3mdvB-2oewA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 132
LEU A 237
VAL A 241
PHE A 125
ALA A  98
 None
 1.44A 3u9fD-2oewA:
undetectable
3u9fE-2oewA:
undetectable		 3u9fD-2oewA:
16.15
3u9fE-2oewA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 132
LEU A 237
VAL A 241
PHE A 125
ALA A  98
 None
 1.41A 3u9fG-2oewA:
undetectable
3u9fH-2oewA:
undetectable		 3u9fG-2oewA:
16.15
3u9fH-2oewA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 123
ASN A 126
CYH A 127
LEU A  58
ARG A  50
 None
 1.28A 4po0A-2oewA:
2.2		 4po0A-2oewA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 131
LEU A 130
ALA A 129
PHE A 125
LEU A 187
 None
 1.20A 5k9dA-2oewA:
undetectable		 5k9dA-2oewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  93
ILE A  78
ILE A  75
SER A 121
LEU A  21
 None
 1.14A 5uanB-2oewA:
1.5		 5uanB-2oewA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A  50
TYR A  71
GLU A 119
LEU A  21
 None
 1.19A 5umwB-2oewA:
undetectable
5umwE-2oewA:
undetectable		 5umwB-2oewA:
15.91
5umwE-2oewA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 ALA A 128
ALA A 131
ALA A 156
ALA A 159
 None
 0.73A 6gtqA-2oewA:
0.0
6gtqB-2oewA:
0.0		 6gtqA-2oewA:
20.42
6gtqB-2oewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 ALA A 156
ALA A 159
ALA A 128
ALA A 131
 None
 0.73A 6gtqA-2oewA:
0.0
6gtqB-2oewA:
0.0		 6gtqA-2oewA:
20.42
6gtqB-2oewA:
20.42