SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		5 / 11 PHE A  33
ASN A 154
LEU A 111
PHE A  42
LEU A  46
 None
 1.43A 1xpqA-2oezA:
0.0		 1xpqA-2oezA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 144
LEU A 138
ALA A 137
SER A 119
LEU A 117
 None
 1.20A 2aa5B-2oezA:
undetectable		 2aa5B-2oezA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 202
LEU A 242
GLN A 183
VAL A 238
THR A   3
 None
 1.15A 2yloA-2oezA:
undetectable		 2yloA-2oezA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		3 / 4 SER A  72
GLY A 178
GLU A   7
 None
 0.69A 3raeA-2oezA:
undetectable
3raeC-2oezA:
undetectable		 3raeA-2oezA:
18.74
3raeC-2oezA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		4 / 8 PHE A  33
ALA A  30
PHE A 124
ALA A  45
 None
 0.96A 3t3sF-2oezA:
undetectable		 3t3sF-2oezA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		3 / 3 LEU A  62
MET A 102
ASP A  95
 None
 0.85A 3v5wA-2oezA:
3.2		 3v5wA-2oezA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 202
LEU A 242
GLN A 183
VAL A 238
THR A   3
 None
 1.12A 3zqtA-2oezA:
undetectable		 3zqtA-2oezA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2oez UPF0289 PROTEIN
VP2528
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 221
ILE A 214
PRO A 205
PHE A 240
 None
 1.00A 5x23A-2oezA:
undetectable		 5x23A-2oezA:
19.44