SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2of3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBM_A_CAMA517_0 (CYTOCHROME P450-CAM)	2of3	ZYG-9 (Caenorhabditis elegans)	4 / 8	THR A 770 VAL A 813 THR A 812 ILE A 801	None	0.90A	2qbmA-2of3A: undetectable	2qbmA-2of3A: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VQ5_B_LDPB1197_1 (S-NORCOCLAURINE SYNTHASE)	2of3	ZYG-9 (Caenorhabditis elegans)	4 / 7	LEU A 640 LEU A 644 PHE A 657 LEU A 695	None	0.96A	2vq5B-2of3A: undetectable	2vq5B-2of3A: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z77_D_NCAD200_0 (PUTATIVE STEROID ISOMERASE)	2of3	ZYG-9 (Caenorhabditis elegans)	5 / 9	SER A 761 LEU A 738 LEU A 773 LEU A 739 TYR A 795	None	1.39A	2z77D-2of3A: undetectable	2z77D-2of3A: 18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BSZ_E_RTLE177_0 (PLASMA RETINOL-BINDING PROTEIN)	2of3	ZYG-9 (Caenorhabditis elegans)	5 / 11	LEU A 652 ALA A 666 ALA A 667 LEU A 689 HIS A 658	None	1.14A	3bszE-2of3A: undetectable	3bszE-2of3A: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_B_EPAB1_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2of3	ZYG-9 (Caenorhabditis elegans)	4 / 7	VAL A 753 VAL A 757 LEU A 760 SER A 761	None	0.70A	3hs6B-2of3A: undetectable	3hs6B-2of3A: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTY_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2of3	ZYG-9 (Caenorhabditis elegans)	5 / 12	LEU A 777 LEU A 790 VAL A 824 ALA A 828 LEU A 832	None	0.94A	4otyA-2of3A: undetectable	4otyA-2of3A: 18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTY_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2of3	ZYG-9 (Caenorhabditis elegans)	5 / 12	LEU A 777 LEU A 790 VAL A 824 ALA A 828 LEU A 832	None	0.93A	4otyB-2of3A: 0.9	4otyB-2of3A: 18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R20_B_AERB602_1 (CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2)	2of3	ZYG-9 (Caenorhabditis elegans)	5 / 9	ALA A 799 VAL A 757 GLY A 765 THR A 770 VAL A 791	None	1.21A	4r20B-2of3A: undetectable	4r20B-2of3A: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_A_CVIA301_0 (REGULATORY PROTEIN TETR)	2of3	ZYG-9 (Caenorhabditis elegans)	5 / 12	MET A 653 ALA A 667 SER A 670 LEU A 605 ASP A 676	None	1.50A	5vlmA-2of3A: undetectable	5vlmA-2of3A: 20.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2QBM_A_CAMA517_0","CYTOCHROME P450-CAM","2of3","ZYG-9","Caenorhabditis elegans",4,"THR A 770;VAL A 813;THR A 812;ILE A 801","None","0.90A","2qbmA-2of3A:undetectable","2qbmA-2of3A:19.62"],["2VQ5_B_LDPB1197_1","S-NORCOCLAURINE SYNTHASE","2of3","ZYG-9","Caenorhabditis elegans",4,"LEU A 640;LEU A 644;PHE A 657;LEU A 695","None","0.96A","2vq5B-2of3A:undetectable","2vq5B-2of3A:23.13"],["2Z77_D_NCAD200_0","PUTATIVE STEROID ISOMERASE","2of3","ZYG-9","Caenorhabditis elegans",5,"SER A 761;LEU A 738;LEU A 773;LEU A 739;TYR A 795","None","1.39A","2z77D-2of3A:undetectable","2z77D-2of3A:18.08"],["3BSZ_E_RTLE177_0","PLASMA RETINOL-BINDING PROTEIN","2of3","ZYG-9","Caenorhabditis elegans",5,"LEU A 652;ALA A 666;ALA A 667;LEU A 689;HIS A 658","None","1.14A","3bszE-2of3A:undetectable","3bszE-2of3A:21.35"],["3HS6_B_EPAB1_2","PROSTAGLANDIN G\/H SYNTHASE 2","2of3","ZYG-9","Caenorhabditis elegans",4,"VAL A 753;VAL A 757;LEU A 760;SER A 761","None","0.70A","3hs6B-2of3A:undetectable","3hs6B-2of3A:18.29"],["4OTY_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","2of3","ZYG-9","Caenorhabditis elegans",5,"LEU A 777;LEU A 790;VAL A 824;ALA A 828;LEU A 832","None","0.94A","4otyA-2of3A:undetectable","4otyA-2of3A:18.31"],["4OTY_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","2of3","ZYG-9","Caenorhabditis elegans",5,"LEU A 777;LEU A 790;VAL A 824;ALA A 828;LEU A 832","None","0.93A","4otyB-2of3A:0.9","4otyB-2of3A:18.31"],["4R20_B_AERB602_1","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","2of3","ZYG-9","Caenorhabditis elegans",5,"ALA A 799;VAL A 757;GLY A 765;THR A 770;VAL A 791","None","1.21A","4r20B-2of3A:undetectable","4r20B-2of3A:20.61"],["5VLM_A_CVIA301_0","REGULATORY PROTEIN TETR","2of3","ZYG-9","Caenorhabditis elegans",5,"MET A 653;ALA A 667;SER A 670;LEU A 605;ASP A 676","None","1.50A","5vlmA-2of3A:undetectable","5vlmA-2of3A:20.68"]]