SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2of5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 ALA H 856
LEU H 857
LEU H 853
LEU H 787
ALA H 796
 None
 1.01A 1h9zA-2of5H:
undetectable		 1h9zA-2of5H:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 ALA H 856
LEU H 857
LEU H 853
LEU H 787
ALA H 796
 None
 1.00A 1ha2A-2of5H:
undetectable		 1ha2A-2of5H:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU H 799
LEU H 836
GLN H 863
LEU H 779
VAL H 869
 None
 1.37A 2qd4B-2of5H:
undetectable		 2qd4B-2of5H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2of5 DEATH
DOMAIN-CONTAINING
PROTEIN CRADD
(Homo
sapiens) 		5 / 11 ILE A 165
ALA A 163
LEU A 123
ILE A 120
SER A 179
 None
 1.01A 2w9sA-2of5A:
undetectable		 2w9sA-2of5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2of5 DEATH
DOMAIN-CONTAINING
PROTEIN CRADD
(Homo
sapiens) 		5 / 11 ILE A 165
ALA A 163
LEU A 123
ILE A 120
SER A 179
 None
 0.97A 2w9sB-2of5A:
undetectable		 2w9sB-2of5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2of5 DEATH
DOMAIN-CONTAINING
PROTEIN CRADD
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 177
ARG A 118
MET A 197
 None
 1.20A 2zxwN-2of5A:
undetectable
2zxwW-2of5A:
undetectable		 2zxwN-2of5A:
12.25
2zxwW-2of5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 VAL H 795
ALA H 796
GLY H 797
LEU H 787
PHE H 837
 None
 1.08A 3qxyA-2of5H:
undetectable		 3qxyA-2of5H:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 VAL H 795
ALA H 796
GLY H 797
LEU H 787
PHE H 837
 None
 1.04A 3rc0A-2of5H:
undetectable		 3rc0A-2of5H:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 VAL H 795
ALA H 796
GLY H 797
LEU H 787
PHE H 837
 None
 1.05A 3rc0B-2of5H:
undetectable		 3rc0B-2of5H:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 9 ALA H 840
LEU H 836
LEU H 793
ASN H 791
ILE H 832
 None
 1.40A 3wdmA-2of5H:
undetectable		 3wdmA-2of5H:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 TRP H 839
LEU H 787
LEU H 779
GLY H 780
 None
 0.87A 4c9nA-2of5H:
undetectable		 4c9nA-2of5H:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2of5 DEATH
DOMAIN-CONTAINING
PROTEIN CRADD
(Homo
sapiens) 		4 / 8 LEU A 180
PHE A 177
ARG A 118
MET A 197
 None
 0.95A 5zcoA-2of5A:
undetectable
5zcoJ-2of5A:
undetectable		 5zcoA-2of5A:
12.25
5zcoJ-2of5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 HIS H 834
ARG H 819
ILE H 820
 None
 0.85A 6fgdA-2of5H:
undetectable		 6fgdA-2of5H:
15.76