SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ofk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		3 / 3 TRP A  46
VAL A   7
TRP A  21
 PGE  A 701 (-3.6A)
None
PGE  A 701 ( 4.6A)
 1.48A 1gmkC-2ofkA:
undetectable
1gmkD-2ofkA:
undetectable		 1gmkC-2ofkA:
9.21
1gmkD-2ofkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		4 / 7 ASN A 173
HIS A 175
ILE A 135
TRP A   6
 None
ZN  A 201 (-3.1A)
None
PGE  A 701 (-3.4A)
 1.48A 1tdnA-2ofkA:
undetectable		 1tdnA-2ofkA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		5 / 12 ALA A  94
PHE A 156
GLY A 158
THR A 159
THR A 160
 None
 0.92A 2zifA-2ofkA:
undetectable		 2zifA-2ofkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		5 / 11 ALA A 101
LEU A 103
ARG A 100
ILE A  68
PRO A  65
 None
None
PGE  A 903 (-2.9A)
None
None
 1.00A 3bpxA-2ofkA:
undetectable
3bpxB-2ofkA:
undetectable		 3bpxA-2ofkA:
21.28
3bpxB-2ofkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		3 / 3 GLU A 106
ASP A 114
ASP A  27
 None
PGE  A 904 (-4.0A)
None
 0.75A 3jb2A-2ofkA:
undetectable		 3jb2A-2ofkA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		5 / 10 ARG A  89
GLU A  74
LEU A  79
LEU A  80
ILE A  92
 None
 1.01A 3kvrA-2ofkA:
undetectable		 3kvrA-2ofkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		5 / 12 PHE A  63
PHE A  32
LEU A  44
ILE A  86
ALA A  94
 None
 1.14A 4a83A-2ofkA:
undetectable		 4a83A-2ofkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		4 / 5 GLU A  25
LYS A  30
GLU A  33
GLU A  20
 None
 1.35A 5onlA-2ofkA:
0.0		 5onlA-2ofkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		4 / 5 GLU A  25
LYS A  30
GLU A  33
GLU A  20
 None
 1.30A 6hrjA-2ofkA:
0.0		 6hrjA-2ofkA:
20.56