SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ofx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 GLU A 108
ARG A 111
ARG A 112
LEU A  99
 None
 0.91A 1cmaA-2ofxA:
undetectable
1cmaB-2ofxA:
undetectable		 1cmaA-2ofxA:
19.81
1cmaB-2ofxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 10 LEU A 119
ALA A 123
LEU A 125
HIS A 146
LEU A 151
 None
 1.49A 1pcgB-2ofxA:
undetectable		 1pcgB-2ofxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 ASN A  96
GLY A  88
ASP A  89
PHE A 101
GLY A 100
 None
PPS  A1100 (-3.6A)
PPS  A1100 (-2.7A)
PPS  A1100 (-3.5A)
None
 1.48A 2fqyA-2ofxA:
4.2		 2fqyA-2ofxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 10 LEU A 119
ALA A 123
LEU A 125
HIS A 146
LEU A 151
 None
 1.48A 2ocfA-2ofxA:
undetectable		 2ocfA-2ofxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 PRO A  82
LEU A 125
ARG A  40
 None
 0.86A 3aqiB-2ofxA:
undetectable		 3aqiB-2ofxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 GLY A  62
GLY A  64
THR A  66
 ADP  A1300 (-3.4A)
ADP  A1300 (-3.3A)
MG  A 301 ( 3.1A)
 0.44A 3si7B-2ofxA:
2.7		 3si7B-2ofxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 THR A 204
ALA A 160
LEU A 162
VAL A 158
 ADP  A1300 (-4.0A)
None
None
None
 0.95A 4iizB-2ofxA:
undetectable		 4iizB-2ofxA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 7 ASP A 159
PRO A 161
ASP A 205
SER A 206
 None
PO4  A 403 (-4.2A)
None
None
 1.27A 4k7gB-2ofxA:
undetectable		 4k7gB-2ofxA:
21.33