SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2og7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 7 PHE A 216
GLU A 125
GLN A 132
ASN A 158
 None
AHB  A7002 (-3.2A)
None
AHB  A7002 (-3.5A)
 1.43A 1jqdA-2og7A:
0.8		 1jqdA-2og7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 11 ASN A  95
GLU A 125
ALA A 147
GLY A 148
PHE A 307
 None
AHB  A7002 (-3.2A)
None
None
None
 1.49A 1l5rA-2og7A:
undetectable		 1l5rA-2og7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.41A 1nncA-2og7A:
undetectable		 1nncA-2og7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 7 VAL A 228
LEU A 229
ALA A 255
LEU A 256
 None
 0.75A 1pthA-2og7A:
undetectable		 1pthA-2og7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 7 VAL A 228
LEU A 229
ALA A 255
LEU A 256
 None
 0.76A 1pthB-2og7A:
undetectable		 1pthB-2og7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.48A 2cmlC-2og7A:
undetectable		 2cmlC-2og7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 9 ARG A  79
GLY A  80
THR A 185
VAL A  77
VAL A 280
 None
 1.25A 2nnhB-2og7A:
undetectable		 2nnhB-2og7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 9 GLY A 115
THR A 112
ALA A 113
LEU A 110
THR A 306
 None
 1.30A 2npnA-2og7A:
undetectable		 2npnA-2og7A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 PHE A 208
VAL A 191
LEU A 229
GLN A 260
LEU A 242
 None
 1.34A 2rctA-2og7A:
undetectable		 2rctA-2og7A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 182
LEU A 170
VAL A 168
ALA A 181
GLY A 145
 None
None
None
None
AHB  A7002 (-3.0A)
 1.00A 2vmyA-2og7A:
undetectable		 2vmyA-2og7A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 THR A 306
LEU A 110
VAL A  45
VAL A 325
 None
 1.05A 2zuhA-2og7A:
undetectable		 2zuhA-2og7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 THR A 306
LEU A 110
VAL A  45
VAL A 325
 None
 1.09A 2zuiA-2og7A:
undetectable		 2zuiA-2og7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 HIS A 262
THR A 266
PHE A 263
LEU A 195
 None
 1.13A 3bgdA-2og7A:
undetectable		 3bgdA-2og7A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 PRO A 214
LEU A 152
ALA A 243
PRO A 213
 None
None
None
AHB  A7002 (-4.2A)
 1.25A 3gv1A-2og7A:
undetectable
3gv1C-2og7A:
undetectable		 3gv1A-2og7A:
17.09
3gv1C-2og7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 LEU A 152
ALA A 243
PRO A 213
PRO A 214
 None
None
AHB  A7002 (-4.2A)
None
 1.28A 3gv1A-2og7A:
undetectable
3gv1B-2og7A:
undetectable		 3gv1A-2og7A:
17.09
3gv1B-2og7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 7 ARG A  67
ASP A 118
PHE A 167
ARG A 283
 None
 1.36A 3kivA-2og7A:
undetectable		 3kivA-2og7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 170
PHE A 307
VAL A 168
PRO A 165
ASN A 158
 None
None
None
None
AHB  A7002 (-3.5A)
 1.39A 3nuvB-2og7A:
0.0		 3nuvB-2og7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		3 / 3 THR A 153
ASP A 241
GLU A 157
 None
AHB  A7002 (-4.3A)
FE2  A5001 (-2.5A)
 0.85A 3qowA-2og7A:
undetectable		 3qowA-2og7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.48A 3ticB-2og7A:
undetectable		 3ticB-2og7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.50A 3ticC-2og7A:
undetectable		 3ticC-2og7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.48A 3ticD-2og7A:
undetectable		 3ticD-2og7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		3 / 3 ARG A  67
ARG A 283
ASP A 311
 None
 0.90A 3wipG-2og7A:
undetectable
3wipH-2og7A:
undetectable		 3wipG-2og7A:
20.17
3wipH-2og7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 130
ALA A  35
GLU A  46
ALA A  48
GLY A  37
 None
 1.09A 4hfpD-2og7A:
undetectable		 4hfpD-2og7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  32
GLN A  99
LEU A  88
PRO A  89
LEU A 173
 None
 1.09A 4m2xE-2og7A:
undetectable		 4m2xE-2og7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 5 GLY A 148
SER A 149
PHE A 143
GLU A 142
 None
 1.06A 4m93B-2og7A:
undetectable
4m93C-2og7A:
undetectable		 4m93B-2og7A:
20.17
4m93C-2og7A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 PRO A 236
LEU A 229
VAL A 188
GLY A 288
THR A 185
 None
 1.45A 4mubA-2og7A:
undetectable		 4mubA-2og7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.44A 4mwrA-2og7A:
undetectable		 4mwrA-2og7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.42A 4mwxA-2og7A:
undetectable		 4mwxA-2og7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 7 LEU A 272
ALA A  75
LEU A  78
ARG A  79
 None
 0.73A 4ubsA-2og7A:
undetectable		 4ubsA-2og7A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 11 LEU A  59
ARG A  60
LEU A  16
GLU A  25
ALA A  28
 None
 1.07A 4wg0F-2og7A:
undetectable
4wg0G-2og7A:
undetectable
4wg0H-2og7A:
undetectable		 4wg0F-2og7A:
4.20
4wg0G-2og7A:
4.20
4wg0H-2og7A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 11 LEU A  59
ARG A  60
LEU A  16
GLU A  25
ALA A  28
 None
 1.05A 4wg0J-2og7A:
undetectable
4wg0K-2og7A:
undetectable
4wg0L-2og7A:
undetectable		 4wg0J-2og7A:
4.20
4wg0K-2og7A:
4.20
4wg0L-2og7A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ASN A 158
SER A 219
ALA A 244
GLU A 157
LEU A 152
 AHB  A7002 (-3.5A)
None
None
FE2  A5001 (-2.5A)
None
 1.16A 4zjoA-2og7A:
undetectable		 4zjoA-2og7A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.38A 5l17A-2og7A:
undetectable		 5l17A-2og7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 259
THR A 153
ARG A 239
ARG A 209
 None
 1.27A 6ew0B-2og7A:
undetectable		 6ew0B-2og7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 259
THR A 153
ARG A 239
ARG A 209
 None
 1.27A 6ew0D-2og7A:
undetectable		 6ew0D-2og7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 259
THR A 153
ARG A 239
ARG A 209
 None
 1.27A 6ew0H-2og7A:
undetectable		 6ew0H-2og7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 259
THR A 153
ARG A 239
ARG A 209
 None
 1.27A 6ew0I-2og7A:
undetectable		 6ew0I-2og7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 257
ARG A 251
GLU A 250
ALA A 205
GLU A 207
 None
 1.42A 6hcxA-2og7A:
undetectable		 6hcxA-2og7A:
10.31