SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2og9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A  62
VAL A  18
ALA A  52
ASP A 128
ALA A 125
 None
 1.41A 2avdB-2og9A:
undetectable		 2avdB-2og9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 4 LEU A 285
PRO A 287
LEU A 312
ARG A 330
 None
 1.36A 2qd2A-2og9A:
undetectable		 2qd2A-2og9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 6 PHE A 344
PRO A 290
ALA A 317
LEU A 320
 None
 0.70A 2vcvB-2og9A:
undetectable		 2vcvB-2og9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 6 PHE A 344
PRO A 290
ALA A 317
LEU A 320
 None
 0.68A 2vcvK-2og9A:
undetectable		 2vcvK-2og9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 TYR A  67
ILE A  47
LEU A 343
LEU A 340
 None
 0.94A 2zb7A-2og9A:
undetectable		 2zb7A-2og9A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 204
LEU A 166
ALA A 170
VAL A 197
LYS A 184
 None
 1.19A 3e22B-2og9A:
3.1		 3e22B-2og9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 204
LEU A 166
ALA A 170
VAL A 197
LYS A 184
 None
 1.22A 3e22D-2og9A:
3.0		 3e22D-2og9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 6 GLU A 265
PRO A 290
ARG A 291
GLY A 264
 None
 1.25A 3oxvA-2og9A:
undetectable		 3oxvA-2og9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 7 GLU A 349
ARG A 347
GLU A 346
PRO A 358
 None
 1.24A 3ql6A-2og9A:
1.2		 3ql6A-2og9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 11 ALA A  80
LEU A 129
ILE A  15
LEU A  50
GLY A  64
 None
 1.16A 3zosA-2og9A:
undetectable
3zosB-2og9A:
undetectable		 3zosA-2og9A:
24.21
3zosB-2og9A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 293
GLY A 120
ILE A 295
VAL A 124
ASP A 288
 None
 1.09A 4a6dA-2og9A:
undetectable		 4a6dA-2og9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 293
GLY A 120
ILE A 295
VAL A 124
ASP A 288
 None
 1.13A 4a6eA-2og9A:
undetectable		 4a6eA-2og9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 GLY A 143
TYR A 328
TYR A 145
GLU A 306
 None
 1.24A 4ae1B-2og9A:
2.8		 4ae1B-2og9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 10 ASP A 128
GLY A 120
ILE A 119
VAL A  18
ILE A  54
 None
 1.05A 4dqcA-2og9A:
undetectable		 4dqcA-2og9A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 6 PHE A 298
ALA A 302
ALA A 327
LEU A 312
 None
 0.97A 4dtzA-2og9A:
undetectable		 4dtzA-2og9A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 7 ALA A 289
PRO A 297
LEU A 324
LEU A 320
 None
 0.93A 4iomA-2og9A:
2.6		 4iomA-2og9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 ALA A 289
PRO A 297
LEU A 324
LEU A 320
 None
 0.91A 4jjkA-2og9A:
undetectable		 4jjkA-2og9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 LEU A 343
PRO A 342
ARG A 376
 None
 0.72A 4klrB-2og9A:
undetectable		 4klrB-2og9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 ALA A  48
GLY A  75
PRO A  74
GLY A  72
ILE A  83
 None
 1.01A 4n49A-2og9A:
undetectable		 4n49A-2og9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 9 ALA A  80
ALA A  78
SER A  68
ALA A 118
SER A  66
 None
 1.16A 4twdA-2og9A:
undetectable
4twdB-2og9A:
undetectable
4twdC-2og9A:
undetectable
4twdD-2og9A:
undetectable
4twdE-2og9A:
undetectable		 4twdA-2og9A:
21.88
4twdB-2og9A:
21.88
4twdC-2og9A:
21.88
4twdD-2og9A:
21.88
4twdE-2og9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 9 ALA A 118
SER A  66
ALA A  80
ALA A  78
SER A  68
 None
 1.17A 4twdA-2og9A:
undetectable
4twdB-2og9A:
undetectable
4twdC-2og9A:
undetectable
4twdD-2og9A:
undetectable
4twdE-2og9A:
undetectable		 4twdA-2og9A:
21.88
4twdB-2og9A:
21.88
4twdC-2og9A:
21.88
4twdD-2og9A:
21.88
4twdE-2og9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 10 ALA A 139
ALA A 326
VAL A 149
LEU A 320
VAL A 334
 None
 1.46A 5eb5B-2og9A:
undetectable		 5eb5B-2og9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 6 PHE A  65
GLU A 319
GLU A 335
VAL A 334
 None
 1.34A 5h4dA-2og9A:
undetectable		 5h4dA-2og9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 10 ILE A  49
LEU A 343
GLY A  64
ALA A 121
PHE A  65
 None
 1.04A 5mxbA-2og9A:
undetectable		 5mxbA-2og9A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 VAL A 212
PHE A 233
LEU A 235
ILE A 229
 None
 0.78A 5nujA-2og9A:
undetectable		 5nujA-2og9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 199
LEU A 183
ILE A 194
PHE A 233
LEU A 235
 None
 1.27A 5uanB-2og9A:
undetectable		 5uanB-2og9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 204
GLY A 180
GLY A 179
MET A 211
LEU A 183
 None
 1.18A 5uc1A-2og9A:
undetectable		 5uc1A-2og9A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 340
HIS A 336
LEU A 365
ILE A 348
 None
 1.00A 5v0vA-2og9A:
2.0		 5v0vA-2og9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 10 PRO A 314
PRO A 332
ALA A 305
GLY A 274
ILE A 277
 None
 1.33A 5vyhA-2og9A:
undetectable		 5vyhA-2og9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		6 / 12 PHE A 122
ALA A  78
GLY A  73
GLY A  64
ALA A 125
SER A  68
 None
 1.46A 5w4zB-2og9A:
5.3		 5w4zB-2og9A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 GLY A 294
ILE A 295
ASP A 288
PRO A 314
 None
 0.93A 6ag0A-2og9A:
8.3		 6ag0A-2og9A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 204
ARG A 196
VAL A 200
THR A 154
GLY A 156
 None
 1.00A 6brdA-2og9A:
undetectable		 6brdA-2og9A:
13.07