SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 8 LEU A 136
ALA A 186
GLY A 179
ILE A 178
VAL A 162
 None
 1.43A 1d4sB-2ogaA:
undetectable		 1d4sB-2ogaA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 10 MET A 147
LEU A 150
LEU A 153
ALA A 154
HIS A 139
 None
 1.30A 1gwrA-2ogaA:
undetectable		 1gwrA-2ogaA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 8 ASP A 164
ALA A 166
GLY A 201
GLY A 202
ALA A  99
 PGU  A1020 (-2.6A)
PGU  A1020 (-3.5A)
None
None
None
 1.00A 1sguA-2ogaA:
undetectable		 1sguA-2ogaA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 11 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.23A 2a1nA-2ogaA:
undetectable		 2a1nA-2ogaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 10 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.21A 2cp4A-2ogaA:
undetectable		 2cp4A-2ogaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 PRO A 117
HIS A 139
ASP A 148
ASP A 146
 None
 1.40A 2lh8A-2ogaA:
undetectable		 2lh8A-2ogaA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 8 LEU A 159
LEU A 135
LEU A  75
ALA A 105
 None
 0.88A 2vcvF-2ogaA:
undetectable		 2vcvF-2ogaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 8 SER A  36
ARG A  32
ALA A 243
ALA A 244
 None
 1.01A 3ax9B-2ogaA:
undetectable		 3ax9B-2ogaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		3 / 3 LEU A  41
VAL A  33
ARG A  38
 None
 0.68A 3b0wB-2ogaA:
undetectable		 3b0wB-2ogaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 277
ALA A 373
ALA A 368
LEU A 351
ILE A 312
 None
 0.99A 3gwsX-2ogaA:
undetectable		 3gwsX-2ogaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 10 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.20A 3lxiA-2ogaA:
undetectable		 3lxiA-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 11 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.16A 3lxiB-2ogaA:
undetectable		 3lxiB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 8 SER A  36
ARG A  32
ALA A 243
ALA A 244
 None
 0.93A 3ns1L-2ogaA:
undetectable		 3ns1L-2ogaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 PHE A 187
PHE A 189
ALA A  53
THR A  58
 None
 0.90A 3t3sB-2ogaA:
undetectable		 3t3sB-2ogaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 8 PHE A 187
PHE A 189
ALA A  53
THR A  58
 None
 1.01A 3t3sE-2ogaA:
undetectable		 3t3sE-2ogaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 5 HIS A 317
SER A 350
THR A 294
ASP A  14
 None
 1.23A 3tm4A-2ogaA:
2.2		 3tm4A-2ogaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 5 HIS A 317
SER A 350
THR A 294
ASP A  14
 None
 1.19A 3tm4B-2ogaA:
undetectable		 3tm4B-2ogaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		3 / 3 PRO A 112
ASP A 120
GLU A 114
 None
 0.86A 3v4tC-2ogaA:
undetectable		 3v4tC-2ogaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 GLU A 335
GLY A 336
LEU A 324
GLU A 111
 None
 0.92A 3w9tB-2ogaA:
undetectable		 3w9tB-2ogaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 GLU A 335
GLY A 336
LEU A 324
GLU A 111
 None
 0.90A 3w9tE-2ogaA:
undetectable		 3w9tE-2ogaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 GLU A 335
GLY A 336
LEU A 324
GLU A 111
 None
 0.90A 3w9tF-2ogaA:
undetectable		 3w9tF-2ogaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 9 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.27A 4c9kB-2ogaA:
undetectable		 4c9kB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 10 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.26A 4c9nB-2ogaA:
undetectable		 4c9nB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 9 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.22A 4c9pA-2ogaA:
undetectable		 4c9pA-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 10 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.17A 4c9pB-2ogaA:
undetectable		 4c9pB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 12 ALA A  50
ALA A 243
ALA A 203
GLY A  63
LEU A 238
 None
 1.08A 4oaeA-2ogaA:
undetectable		 4oaeA-2ogaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 8 GLU A  46
GLY A  47
VAL A  33
SER A  36
 None
 0.84A 4r20A-2ogaA:
undetectable		 4r20A-2ogaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 GLU A  46
GLY A  67
ASP A  69
GLY A 201
 None
PGU  A1020 (-3.4A)
None
None
 0.88A 5cdnA-2ogaA:
0.8
5cdnB-2ogaA:
undetectable		 5cdnA-2ogaA:
21.65
5cdnB-2ogaA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 9 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.32A 5cp4A-2ogaA:
undetectable		 5cp4A-2ogaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 HIS A 169
LEU A 253
CYH A 197
LEU A 246
 None
 1.27A 5hrqD-2ogaA:
undetectable
5hrqG-2ogaA:
undetectable
5hrqH-2ogaA:
undetectable		 5hrqD-2ogaA:
8.28
5hrqG-2ogaA:
7.26
5hrqH-2ogaA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 12 GLY A 258
ASN A 257
HIS A 143
ALA A 168
SER A 350
 None
 1.14A 5igyA-2ogaA:
undetectable		 5igyA-2ogaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 12 THR A  92
ILE A  94
LEU A  98
LEU A  71
ALA A  95
 None
None
None
None
PGU  A1020 (-3.5A)
 1.04A 5l0zA-2ogaA:
undetectable		 5l0zA-2ogaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		4 / 6 ARG A 304
ARG A 300
LEU A 303
ALA A 368
 None
 1.09A 6b89B-2ogaA:
undetectable		 6b89B-2ogaA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2oga TRANSAMINASE
(Streptomyces
venezuelae) 		5 / 10 GLY A  77
LEU A  78
THR A 103
VAL A  86
ALA A 105
 None
 1.09A 6czmA-2ogaA:
undetectable
6czmC-2ogaA:
undetectable		 6czmA-2ogaA:
24.94
6czmC-2ogaA:
24.94