SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ohc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		3 / 3 TYR A 279
GLU A 238
TYR A 229
 None
 0.82A 3ug8A-2ohcA:
undetectable		 3ug8A-2ohcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A  52
ILE A  22
TYR A  26
TYR A  75
TYR A  72
 None
 1.43A 4a79A-2ohcA:
undetectable		 4a79A-2ohcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		5 / 11 ILE A  52
ILE A  22
TYR A  26
TYR A  75
TYR A  72
 None
 1.40A 4a7aA-2ohcA:
undetectable		 4a7aA-2ohcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		4 / 6 VAL A 228
LEU A 230
ILE A 215
CYH A 214
 None
 0.80A 4asdA-2ohcA:
undetectable		 4asdA-2ohcA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A  90
VAL A  85
GLU A  87
TYR A  93
 None
 0.91A 4fgzA-2ohcA:
undetectable		 4fgzA-2ohcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A 211
GLY A 147
LEU A 230
VAL A 228
 None
 0.83A 4fgzA-2ohcA:
undetectable		 4fgzA-2ohcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A  90
VAL A  85
GLU A  87
TYR A  93
 None
 0.90A 4fgzB-2ohcA:
undetectable		 4fgzB-2ohcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		4 / 7 ALA A  74
VAL A  67
ARG A  71
TYR A  41
 None
 1.16A 4ijiH-2ohcA:
undetectable		 4ijiH-2ohcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		3 / 3 TYR A 138
ARG A 258
SER A 254
 None
 0.99A 4khpI-2ohcA:
undetectable
4khpJ-2ohcA:
undetectable		 4khpI-2ohcA:
20.14
4khpJ-2ohcA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		3 / 3 LEU A 102
ASP A 124
TYR A 125
 None
 0.66A 4qc6B-2ohcA:
undetectable		 4qc6B-2ohcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2ohc TRNA-SPLICING
ENDONUCLEASE
(Thermoplasma
acidophilum) 		5 / 11 VAL A 241
SER A 242
TYR A 239
PRO A 145
LEU A 209
 None
 1.27A 5jh7D-2ohcA:
undetectable		 5jh7D-2ohcA:
23.13