SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ohf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		5 / 12 GLY A 299
LEU A  88
GLY A  26
PHE A  38
SER A  62
 None
 1.08A 1fduA-2ohfA:
3.4		 1fduA-2ohfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		4 / 8 LEU A 111
VAL A  28
GLY A  29
GLU A 151
 None
 1.04A 1jlfA-2ohfA:
undetectable
1jlfB-2ohfA:
undetectable		 1jlfA-2ohfA:
21.92
1jlfB-2ohfA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		3 / 3 LEU A  88
PHE A 300
ARG A 317
 None
 0.85A 1xdkB-2ohfA:
undetectable		 1xdkB-2ohfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		3 / 3 LEU A  88
PHE A 300
ARG A 317
 None
 0.85A 1xdkF-2ohfA:
undetectable		 1xdkF-2ohfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		3 / 3 ASP A  68
PHE A 309
ARG A  70
 None
 0.75A 2a3aA-2ohfA:
2.7		 2a3aA-2ohfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		5 / 12 SER A  62
PHE A  87
THR A  43
LEU A 292
ILE A 296
 None
 1.25A 2xrlA-2ohfA:
undetectable		 2xrlA-2ohfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		4 / 8 ILE A  27
LEU A 123
PHE A 263
GLY A 265
 None
 1.02A 3selX-2ohfA:
undetectable		 3selX-2ohfA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		3 / 3 TYR A 368
GLU A 351
TYR A 350
 None
 0.73A 3ug8A-2ohfA:
undetectable		 3ug8A-2ohfA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		5 / 8 ASP A 381
ILE A 382
GLY A 380
PHE A 309
SER A  82
 None
 1.41A 4acbB-2ohfA:
12.7
4acbC-2ohfA:
11.7		 4acbB-2ohfA:
23.06
4acbC-2ohfA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		3 / 3 PHE A 121
VAL A 251
ILE A 247
 None
 0.61A 4emaA-2ohfA:
undetectable		 4emaA-2ohfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		5 / 12 ILE A  25
GLY A 299
PHE A  38
ILE A  93
VAL A  28
 None
 0.99A 5n0tA-2ohfA:
2.2		 5n0tA-2ohfA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		5 / 12 ILE A  25
GLY A 299
PHE A  38
ILE A  93
VAL A  28
 None
 1.00A 5n0tB-2ohfA:
undetectable		 5n0tB-2ohfA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		4 / 7 LEU A  23
GLY A 119
GLY A  26
SER A  22
 None
 0.75A 5o96C-2ohfA:
undetectable		 5o96C-2ohfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens) 		4 / 8 VAL A  91
ASP A  92
HIS A 113
GLY A  29
 None
 0.92A 5w3jB-2ohfA:
undetectable		 5w3jB-2ohfA:
23.52