SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ohg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		5 / 8 TYR A 126
ASP A 205
GLY A 207
GLY A 182
LEU A 181
 None
 1.31A 1qzzA-2ohgA:
3.3		 1qzzA-2ohgA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		5 / 12 TYR A 186
GLY A  12
GLU A 152
VAL A  13
GLY A  14
 None
 1.33A 3f8wB-2ohgA:
undetectable		 3f8wB-2ohgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		4 / 4 GLN A 246
PRO A 242
VAL A 259
GLU A 260
 None
 1.47A 3huoA-2ohgA:
undetectable		 3huoA-2ohgA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		5 / 11 HIS A 234
PHE A 236
PHE A 245
GLY A  15
GLY A  14
 None
 1.37A 4fglA-2ohgA:
undetectable
4fglB-2ohgA:
undetectable		 4fglA-2ohgA:
21.07
4fglB-2ohgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		4 / 8 ALA A  40
SER A  37
TYR A  42
ARG A  45
 None
 1.18A 4ijiF-2ohgA:
undetectable		 4ijiF-2ohgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 137
ILE A 104
VAL A 112
THR A 178
ILE A 204
 None
 1.27A 5lg3F-2ohgA:
undetectable		 5lg3F-2ohgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 137
ILE A 104
VAL A 112
THR A 178
ILE A 204
 None
 1.27A 5lg3G-2ohgA:
undetectable		 5lg3G-2ohgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 137
ILE A 104
VAL A 112
THR A 178
ILE A 204
 None
 1.25A 5lg3H-2ohgA:
undetectable		 5lg3H-2ohgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2ohg GLUTAMATE RACEMASE
(Streptococcus
pyogenes) 		4 / 7 VAL A 173
PRO A 187
LEU A 188
LEU A 181
 None
 1.21A 6aycA-2ohgA:
undetectable		 6aycA-2ohgA:
14.51