SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oi2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.97A 1fbyA-2oi2A:
undetectable		 1fbyA-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.96A 1fbyB-2oi2A:
undetectable		 1fbyB-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.93A 1fm9A-2oi2A:
undetectable		 1fm9A-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.95A 1k74A-2oi2A:
undetectable		 1k74A-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 4 HIS A 194
ALA A 195
PHE A 192
GLY A 197
 None
 1.41A 1mj2B-2oi2A:
undetectable		 1mj2B-2oi2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 4 HIS A 194
ALA A 195
PHE A 192
GLY A 197
 None
 1.40A 1mjoB-2oi2A:
undetectable		 1mjoB-2oi2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 4 HIS A 194
ALA A 195
PHE A 192
GLY A 197
 None
 1.39A 1mjoA-2oi2A:
undetectable		 1mjoA-2oi2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 4 HIS A 194
ALA A 195
PHE A 192
GLY A 197
 None
 1.43A 1mjoD-2oi2A:
undetectable		 1mjoD-2oi2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.96A 1xiuA-2oi2A:
undetectable		 1xiuA-2oi2A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  97
ILE A 100
ALA A  99
ILE A 126
PHE A 104
 None
 1.17A 1xzxX-2oi2A:
undetectable		 1xzxX-2oi2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.93A 2aclG-2oi2A:
undetectable		 2aclG-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 MET A 158
LEU A  16
ALA A 162
LEU A 164
VAL A 165
 None
 1.10A 2c12C-2oi2A:
undetectable		 2c12C-2oi2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 8 VAL A 182
LEU A 134
GLY A  18
ALA A  28
 None
 0.92A 2xfsA-2oi2A:
1.6		 2xfsA-2oi2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 8 VAL A 182
LEU A 134
GLY A  18
ALA A  28
 None
 0.95A 2xh9A-2oi2A:
undetectable		 2xh9A-2oi2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 258
ILE A  14
LEU A  31
ILE A 263
VAL A  22
 None
None
None
None
DP6  A 300 (-4.6A)
 1.14A 2ygnA-2oi2A:
undetectable		 2ygnA-2oi2A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 8 VAL A 231
ASP A 237
GLY A 259
HIS A 223
 None
 0.96A 3af0A-2oi2A:
undetectable		 3af0A-2oi2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  97
ILE A 100
ALA A  99
ILE A 126
PHE A 104
 None
 1.08A 3gwsX-2oi2A:
undetectable		 3gwsX-2oi2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.96A 3oapA-2oi2A:
undetectable		 3oapA-2oi2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 265
LEU A 219
ALA A 251
ILE A 289
LEU A 275
 None
 1.02A 3q95B-2oi2A:
undetectable		 3q95B-2oi2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 275
ALA A 167
ASP A 168
ILE A  15
 None
 0.95A 4eyrA-2oi2A:
undetectable		 4eyrA-2oi2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.97A 5z12C-2oi2A:
undetectable		 5z12C-2oi2A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.95A 6a5yD-2oi2A:
undetectable		 6a5yD-2oi2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2oi2 MEVALONATE KINASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.94A 6a5zL-2oi2A:
undetectable		 6a5zL-2oi2A:
14.86