SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oi6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 9 ILE A 202
GLY A 127
ILE A 174
ILE A 198
ILE A 201
 None
 0.93A 1hshB-2oi6A:
undetectable		 1hshB-2oi6A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 7 PHE A 260
VAL A 284
VAL A 272
ILE A 274
 None
 0.98A 1p7rA-2oi6A:
undetectable		 1p7rA-2oi6A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 133
GLY A 138
ILE A 152
VAL A 131
ILE A 168
 None
 0.87A 2f8gB-2oi6A:
undetectable		 2f8gB-2oi6A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 11 ILE A 202
GLU A 154
GLY A 171
THR A 170
THR A 199
 None
UD1  A4000 (-2.7A)
UD1  A4000 ( 4.7A)
None
UD1  A4000 (-3.6A)
 1.12A 2fn1B-2oi6A:
undetectable		 2fn1B-2oi6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 133
GLY A 138
ILE A 142
ILE A 152
VAL A 131
 None
 0.84A 2hs1B-2oi6A:
undetectable		 2hs1B-2oi6A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 133
GLY A 138
ILE A 152
VAL A 131
ILE A 168
 None
 0.88A 2hs1B-2oi6A:
undetectable		 2hs1B-2oi6A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 None
 1.25A 2iyfB-2oi6A:
undetectable		 2iyfB-2oi6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 6 LEU A 286
VAL A 284
ILE A 280
ILE A 292
 None
 0.89A 2piwA-2oi6A:
undetectable		 2piwA-2oi6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 9 GLU A 208
ILE A 212
GLY A 125
GLY A 124
LEU A 204
 None
 1.11A 2qmmA-2oi6A:
undetectable		 2qmmA-2oi6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 5 ARG A 237
ASP A 261
ILE A 279
GLU A 236
 None
 1.38A 2xrzA-2oi6A:
undetectable
2xrzB-2oi6A:
undetectable		 2xrzA-2oi6A:
19.88
2xrzB-2oi6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 THR A 382
ILE A 378
GLY A 379
LEU A 409
ILE A 421
 None
None
COA  A2000 ( 4.5A)
None
None
 1.18A 2y7kD-2oi6A:
undetectable		 2y7kD-2oi6A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 11 LEU A  53
ALA A  13
ALA A  12
VAL A  51
GLN A  37
 None
UD1  A4000 (-3.3A)
None
None
None
 1.20A 3bszE-2oi6A:
undetectable		 3bszE-2oi6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 THR A 170
THR A 130
GLU A 167
LEU A 173
ILE A 202
 None
 1.21A 3gwxB-2oi6A:
undetectable		 3gwxB-2oi6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 ALA A 178
ARG A 182
LYS A 186
 None
 0.47A 3kp5B-2oi6A:
undetectable		 3kp5B-2oi6A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 GLU A 236
LEU A  30
LEU A  23
 None
 0.72A 3ohtA-2oi6A:
undetectable		 3ohtA-2oi6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 ASP A 179
VAL A 149
ILE A 142
ILE A 198
ALA A 175
 None
 1.17A 3ohtA-2oi6A:
undetectable
3ohtB-2oi6A:
undetectable		 3ohtA-2oi6A:
20.74
3ohtB-2oi6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 GLU A 236
LEU A  30
LEU A  23
 None
 0.69A 3ohtB-2oi6A:
undetectable		 3ohtB-2oi6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 11 VAL A 344
ALA A 361
GLY A 362
LEU A 332
TYR A 366
 None
 1.26A 3rc0A-2oi6A:
undetectable		 3rc0A-2oi6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 8 ALA A 158
ASP A 157
GLY A 140
ILE A 168
THR A 143
 None
None
UD1  A4000 (-3.3A)
None
None
 1.20A 3so9A-2oi6A:
undetectable		 3so9A-2oi6A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 100
ALA A  89
ILE A 198
LEU A  11
VAL A  54
 None
None
None
UD1  A4000 (-4.1A)
None
 0.97A 3w67C-2oi6A:
undetectable		 3w67C-2oi6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 9 ILE A 109
GLN A 115
LEU A 114
VAL A 215
LEU A 129
 None
 1.22A 4g1bC-2oi6A:
2.7		 4g1bC-2oi6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 11 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 None
 1.26A 4m83A-2oi6A:
undetectable		 4m83A-2oi6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.82A 4o2bD-2oi6A:
undetectable		 4o2bD-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.89A 4o2bD-2oi6A:
undetectable		 4o2bD-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 PRO A 122
VAL A 215
HIS A 216
 None
 0.76A 4pevC-2oi6A:
2.2		 4pevC-2oi6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 PRO A 136
VAL A 131
HIS A 216
 None
 0.81A 4pevC-2oi6A:
2.2		 4pevC-2oi6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 ASP A 200
ILE A 201
ILE A 198
GLY A 171
ILE A 202
 None
None
None
UD1  A4000 ( 4.7A)
None
 0.98A 4q1yB-2oi6A:
undetectable		 4q1yB-2oi6A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 8 GLU A 211
LEU A 173
VAL A 215
GLY A 151
 None
 0.75A 4r3aA-2oi6A:
undetectable		 4r3aA-2oi6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 1.08A 4x1iB-2oi6A:
undetectable		 4x1iB-2oi6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.97A 4x20B-2oi6A:
undetectable		 4x20B-2oi6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 0.88A 4x20B-2oi6A:
undetectable		 4x20B-2oi6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 7 LEU A 102
THR A 170
THR A 113
LEU A 117
 None
 0.96A 4z91F-2oi6A:
undetectable
4z91G-2oi6A:
undetectable
4z91H-2oi6A:
undetectable
4z91I-2oi6A:
undetectable
4z91J-2oi6A:
undetectable		 4z91F-2oi6A:
22.32
4z91G-2oi6A:
22.32
4z91H-2oi6A:
22.32
4z91I-2oi6A:
22.32
4z91J-2oi6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 ARG A 255
LYS A 291
GLU A 273
 None
 0.63A 5d0yA-2oi6A:
undetectable		 5d0yA-2oi6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.85A 5eypB-2oi6A:
undetectable		 5eypB-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A  46
LEU A 117
THR A 130
ILE A 109
ILE A 172
 None
 1.08A 5mioB-2oi6A:
undetectable		 5mioB-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.85A 5nm5B-2oi6A:
undetectable		 5nm5B-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.89A 5xiwB-2oi6A:
undetectable		 5xiwB-2oi6A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.88A 5xiwD-2oi6A:
undetectable		 5xiwD-2oi6A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 6 SER A 301
ARG A 331
ASP A 369
ASP A 317
 None
 1.07A 5zw4A-2oi6A:
undetectable		 5zw4A-2oi6A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 6 ARG A 118
LEU A 117
ALA A 214
GLN A 115
 None
 1.08A 6b89B-2oi6A:
undetectable		 6b89B-2oi6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 339
GLY A 356
VAL A 415
VAL A 401
ASP A 400
 None
 1.34A 6bxlB-2oi6A:
undetectable		 6bxlB-2oi6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2oi6 BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 7 SER A 359
GLY A 398
VAL A 427
LEU A 409
 None
 0.83A 6dwnB-2oi6A:
undetectable		 6dwnB-2oi6A:
11.73