SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 HIS A 235
LEU A 281
THR A 282
THR A 283
 None
 0.63A 1am6A-2oipA:
undetectable		 1am6A-2oipA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 HIS A 235
LEU A 281
THR A 282
THR A 283
 None
 0.92A 1am6A-2oipA:
undetectable		 1am6A-2oipA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.73A 1ao8A-2oipA:
18.9		 1ao8A-2oipA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
SER A  61
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.90A 1ao8A-2oipA:
18.9		 1ao8A-2oipA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 LYS A 284
ILE A 315
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.43A 1axwA-2oipA:
39.2		 1axwA-2oipA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 LYS A 284
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.49A 1axwB-2oipA:
39.1		 1axwB-2oipA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 11 ALA A 287
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
TYR A 466
ALA A 520
 CB3  A 604 ( 3.2A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.49A 1b02A-2oipA:
34.7		 1b02A-2oipA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
PHE A  36
THR A  58
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.2A)
 0.99A 1bzfA-2oipA:
18.5		 1bzfA-2oipA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
ASP A  32
PHE A  36
THR A  58
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.98A 1bzfA-2oipA:
18.5		 1bzfA-2oipA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.65A 1cd2A-2oipA:
21.7		 1cd2A-2oipA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.50A 1d1gA-2oipA:
19.5		 1d1gA-2oipA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
LYS A  34
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.94A 1d1gA-2oipA:
19.5		 1d1gA-2oipA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 VAL A   9
ALA A  11
ASP A  32
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.52A 1d1gB-2oipA:
19.6		 1d1gB-2oipA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.67A 1ddrA-2oipA:
19.8		 1ddrA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.77A 1ddrA-2oipA:
19.8		 1ddrA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.60A 1ddrB-2oipA:
20.2		 1ddrB-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.62A 1ddsA-2oipA:
20.1		 1ddsA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.62A 1ddsB-2oipA:
20.4		 1ddsB-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.47A 1df7A-2oipA:
21.3		 1df7A-2oipA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 11 ALA A  11
ASP A  32
PHE A  36
SER A  61
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
None
 0.73A 1dg5A-2oipA:
21.1		 1dg5A-2oipA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.62A 1dhfA-2oipA:
22.4		 1dhfA-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.68A 1dhfB-2oipA:
22.7		 1dhfB-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.70A 1dhiA-2oipA:
20.1		 1dhiA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.80A 1dhiA-2oipA:
20.1		 1dhiA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.66A 1dhiB-2oipA:
20.5		 1dhiB-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.70A 1dhjA-2oipA:
20.0		 1dhjA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.78A 1dhjA-2oipA:
20.0		 1dhjA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.73A 1dhjB-2oipA:
20.4		 1dhjB-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.65A 1dlsA-2oipA:
23.0		 1dlsA-2oipA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 11 HIS A 235
SER A 431
LEU A 281
THR A 282
THR A 283
 None
 1.40A 1dmyA-2oipA:
undetectable		 1dmyA-2oipA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.71A 1draA-2oipA:
20.0		 1draA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.80A 1draA-2oipA:
20.0		 1draA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.66A 1draB-2oipA:
20.5		 1draB-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.73A 1drbA-2oipA:
20.0		 1drbA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.82A 1drbA-2oipA:
20.0		 1drbA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.68A 1drbB-2oipA:
20.4		 1drbB-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.59A 1dreA-2oipA:
21.3		 1dreA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
SER A  61
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.65A 1drfA-2oipA:
22.2		 1drfA-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.52A 1dyiA-2oipA:
20.0		 1dyiA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.51A 1dyiB-2oipA:
20.4		 1dyiB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 11 ALA A  11
LEU A  25
PHE A  36
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.34A 1dyrA-2oipA:
21.6		 1dyrA-2oipA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 TYR A 466
GLY A 428
VAL A 247
LEU A 243
ASP A 462
 UMP  A 603 ( 4.3A)
None
None
None
None
 1.40A 1e3vA-2oipA:
undetectable		 1e3vA-2oipA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.73A 1hvyA-2oipA:
19.7		 1hvyA-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.69A 1hvyA-2oipA:
19.7		 1hvyA-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 1.11A 1hvyA-2oipA:
19.7		 1hvyA-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.98A 1hvyA-2oipA:
19.7		 1hvyA-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
ASN A 319
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.74A 1hvyB-2oipA:
44.2		 1hvyB-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASN A 319
ASP A 426
GLY A 430
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.69A 1hvyB-2oipA:
44.2		 1hvyB-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ILE A 315
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 1.01A 1hvyB-2oipA:
44.2		 1hvyB-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 11 GLU A 294
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.74A 1hvyC-2oipA:
19.9		 1hvyC-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ILE A 315
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 1.11A 1hvyC-2oipA:
19.9		 1hvyC-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 GLU A 294
ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.74A 1hvyD-2oipA:
44.3		 1hvyD-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.63A 1hvyD-2oipA:
44.3		 1hvyD-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASN A 319
LEU A 399
ASP A 426
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 1.19A 1hvyD-2oipA:
44.3		 1hvyD-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
LEU A 399
ASP A 426
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 1.05A 1hvyD-2oipA:
44.3		 1hvyD-2oipA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 GLU A 294
ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.66A 1i00A-2oipA:
19.7		 1i00A-2oipA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 GLU A 294
ILE A 315
TRP A 316
LEU A 429
GLY A 430
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
 0.76A 1i00A-2oipA:
19.7		 1i00A-2oipA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 ILE A 315
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.07A 1i00A-2oipA:
19.7		 1i00A-2oipA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
TRP A 316
LEU A 429
GLY A 430
PHE A 433
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
 1.21A 1i00A-2oipA:
19.7		 1i00A-2oipA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.76A 1i00B-2oipA:
19.5		 1i00B-2oipA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.26A 1i00B-2oipA:
19.5		 1i00B-2oipA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 ILE A 315
TRP A 316
ASP A 426
GLY A 430
ASN A 434
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
 0.77A 1i00B-2oipA:
19.5		 1i00B-2oipA:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.46A 1j3jA-2oipA:
9.8		 1j3jA-2oipA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 9 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.40A 1j3jB-2oipA:
23.4		 1j3jB-2oipA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.52A 1jolA-2oipA:
20.0		 1jolA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.52A 1jolB-2oipA:
20.5		 1jolB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 11 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.56A 1jomA-2oipA:
19.5		 1jomA-2oipA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 11 ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.57A 1ju6A-2oipA:
44.1		 1ju6A-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 9 LYS A 284
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.48A 1ju6B-2oipA:
44.1		 1ju6B-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 10 ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.57A 1ju6C-2oipA:
44.1		 1ju6C-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 11 LYS A 284
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.47A 1ju6D-2oipA:
44.2		 1ju6D-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 10 LYS A 284
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.53A 1jujA-2oipA:
43.6		 1jujA-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 10 LYS A 284
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.53A 1jujB-2oipA:
43.5		 1jujB-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 10 LYS A 284
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.53A 1jujC-2oipA:
43.5		 1jujC-2oipA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 10 LYS A 284
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.53A 1jujD-2oipA:
43.5		 1jujD-2oipA:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 TRP A 346
GLY A 290
ALA A 439
ILE A 458
HIS A 403
 None
None
None
None
UMP  A 603 ( 4.4A)
 1.08A 1kxhA-2oipA:
undetectable		 1kxhA-2oipA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.39A 1qzfA-2oipA:
53.3		 1qzfA-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.38A 1qzfB-2oipA:
53.3		 1qzfB-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.39A 1qzfC-2oipA:
53.3		 1qzfC-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.40A 1qzfD-2oipA:
53.3		 1qzfD-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.40A 1qzfE-2oipA:
53.3		 1qzfE-2oipA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.48A 1ra2A-2oipA:
20.4		 1ra2A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.58A 1ra3A-2oipA:
20.4		 1ra3A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.49A 1ra8A-2oipA:
20.3		 1ra8A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.55A 1rb2A-2oipA:
20.4		 1rb2A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.45A 1rb2B-2oipA:
20.4		 1rb2B-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
ASP A  32
LEU A  33
ILE A  62
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.49A 1rb3A-2oipA:
20.6		 1rb3A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.60A 1rb3B-2oipA:
20.7		 1rb3B-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.53A 1rd7A-2oipA:
19.9		 1rd7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.45A 1rd7B-2oipA:
19.8		 1rd7B-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.41A 1re7A-2oipA:
20.0		 1re7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.49A 1re7B-2oipA:
20.0		 1re7B-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.55A 1rg7A-2oipA:
19.1		 1rg7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.66A 1rg7A-2oipA:
19.1		 1rg7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ASP A  32
LEU A  33
PHE A  36
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.60A 1rh3A-2oipA:
21.3		 1rh3A-2oipA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.68A 1rtsA-2oipA:
41.4		 1rtsA-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 8 ILE A 315
TRP A 316
ASP A 426
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.76A 1rtsA-2oipA:
41.4		 1rtsA-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 7 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.56A 1rtsB-2oipA:
42.2		 1rtsB-2oipA:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.53A 1rx2A-2oipA:
21.6		 1rx2A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.57A 1rx3A-2oipA:
21.5		 1rx3A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.53A 1rx7A-2oipA:
19.4		 1rx7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
PHE A  36
THR A  58
LEU A  52
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 1.45A 1rx7A-2oipA:
19.4		 1rx7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.62A 1rx8A-2oipA:
21.2		 1rx8A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.68A 1tdrA-2oipA:
20.0		 1tdrA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 10 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.66A 1tdrB-2oipA:
20.4		 1tdrB-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A  11
ASP A  32
LYS A  38
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
None
MTX  A 605 ( 4.2A)
 1.27A 1tdrB-2oipA:
20.4		 1tdrB-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
LEU A 399
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.50A 1tlsA-2oipA:
39.3		 1tlsA-2oipA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
LEU A 399
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.56A 1tlsB-2oipA:
39.4		 1tlsB-2oipA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
LEU A 399
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.42A 1tsnA-2oipA:
39.2		 1tsnA-2oipA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.56A 1u72A-2oipA:
22.9		 1u72A-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  25
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.45A 2bl9A-2oipA:
22.6		 2bl9A-2oipA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
ASP A  32
PHE A  36
SER A  61
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.2A)
 1.17A 2bl9A-2oipA:
22.6		 2bl9A-2oipA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.72A 2blaA-2oipA:
22.2		 2blaA-2oipA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
THR A  58
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.66A 2cd2A-2oipA:
21.9		 2cd2A-2oipA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.74A 2d0kA-2oipA:
19.8		 2d0kA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.62A 2d0kB-2oipA:
19.9		 2d0kB-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.63A 2drcA-2oipA:
20.1		 2drcA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.72A 2drcA-2oipA:
20.1		 2drcA-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.60A 2drcB-2oipA:
20.5		 2drcB-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 GLU A 294
TRP A 316
LEU A 399
ASP A 426
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.53A 2kceA-2oipA:
39.3		 2kceA-2oipA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.72A 2kceB-2oipA:
39.3		 2kceB-2oipA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
TYR A 466
ALA A 520
 CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.40A 2kceB-2oipA:
39.3		 2kceB-2oipA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 6 LEU A 243
VAL A 247
ILE A 265
ILE A 460
 None
 0.75A 2piwA-2oipA:
undetectable		 2piwA-2oipA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.63A 2qk8A-2oipA:
20.7		 2qk8A-2oipA:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 7 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.70A 2tsrA-2oipA:
41.4		 2tsrA-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.58A 2tsrB-2oipA:
42.0		 2tsrB-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.99A 2tsrB-2oipA:
42.0		 2tsrB-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
TRP A 316
ASP A 426
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.66A 2tsrB-2oipA:
42.0		 2tsrB-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.73A 2tsrC-2oipA:
41.2		 2tsrC-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.07A 2tsrC-2oipA:
41.2		 2tsrC-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
THR A 514
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
None
 0.80A 2tsrD-2oipA:
19.6		 2tsrD-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.12A 2tsrD-2oipA:
19.6		 2tsrD-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
TRP A 316
ASP A 426
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.63A 2tsrD-2oipA:
19.6		 2tsrD-2oipA:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 11 ALA A  11
PHE A  36
THR A  58
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.49A 2w3aA-2oipA:
22.5		 2w3aA-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.64A 2w3aB-2oipA:
22.5		 2w3aB-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.52A 2w3bA-2oipA:
22.4		 2w3bA-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.54A 2w3bB-2oipA:
22.5		 2w3bB-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.58A 2w3mA-2oipA:
22.3		 2w3mA-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.46A 2w3mB-2oipA:
22.5		 2w3mB-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 VAL A   9
ALA A  11
ASP A  32
LEU A  33
PHE A  36
SER A  61
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
None
MTX  A 605 ( 4.2A)
 0.59A 2w3vA-2oipA:
21.6		 2w3vA-2oipA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.69A 2w9gA-2oipA:
21.5		 2w9gA-2oipA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.71A 2w9hA-2oipA:
21.1		 2w9hA-2oipA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.68A 2w9sA-2oipA:
21.5		 2w9sA-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.67A 2w9sB-2oipA:
21.5		 2w9sB-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
LEU A  25
ASP A  32
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.68A 2w9sC-2oipA:
21.5		 2w9sC-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
None
MTX  A 605 ( 4.2A)
 0.54A 2w9sD-2oipA:
21.1		 2w9sD-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ALA A  11
LEU A  25
ASP A  32
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 4.2A)
 0.41A 2w9sE-2oipA:
21.2		 2w9sE-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
None
MTX  A 605 ( 4.2A)
 0.50A 2w9sF-2oipA:
21.0		 2w9sF-2oipA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.58A 2zzaA-2oipA:
21.4		 2zzaA-2oipA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.59A 2zzaB-2oipA:
21.4		 2zzaB-2oipA:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
THR A  58
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.71A 3cl9A-2oipA:
18.6		 3cl9A-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_A_TMQA611_1
(DHFR-TS)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 VAL A   9
ALA A  11
ASP A  32
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.50A 3clbA-2oipA:
18.1		 3clbA-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_B_TMQB612_1
(DHFR-TS)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
PHE A  36
THR A  58
SER A  61
ILE A  62
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
 0.60A 3clbB-2oipA:
23.1		 3clbB-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_C_TMQC613_1
(DHFR-TS)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 VAL A   9
ALA A  11
ASP A  32
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.44A 3clbC-2oipA:
18.8		 3clbC-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_D_TMQD614_1
(DHFR-TS)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 VAL A   9
ALA A  11
ASP A  32
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.44A 3clbD-2oipA:
19.3		 3clbD-2oipA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.60A 3datA-2oipA:
21.1		 3datA-2oipA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.56A 3dauA-2oipA:
21.4		 3dauA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.51A 3dfrA-2oipA:
21.2		 3dfrA-2oipA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.55A 3dfrA-2oipA:
21.2		 3dfrA-2oipA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.65A 3drcA-2oipA:
20.0		 3drcA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.74A 3drcA-2oipA:
20.0		 3drcA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.61A 3drcB-2oipA:
20.5		 3drcB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.65A 3eigA-2oipA:
22.0		 3eigA-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A  11
LEU A  25
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.96A 3fl9A-2oipA:
20.6		 3fl9A-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
LEU A  33
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.73A 3fl9B-2oipA:
20.2		 3fl9B-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 LEU A  33
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.81A 3fl9B-2oipA:
20.2		 3fl9B-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ALA A  11
LEU A  25
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.90A 3fl9D-2oipA:
21.0		 3fl9D-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A  11
LEU A  25
LEU A  33
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.67A 3fl9E-2oipA:
20.5		 3fl9E-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A  11
LEU A  33
ILE A  62
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.85A 3fl9E-2oipA:
20.5		 3fl9E-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
LEU A  33
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.75A 3fl9G-2oipA:
20.5		 3fl9G-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  33
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.87A 3fl9G-2oipA:
20.5		 3fl9G-2oipA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.66A 3frbX-2oipA:
21.5		 3frbX-2oipA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 9 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.71A 3freX-2oipA:
21.4		 3freX-2oipA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 HIS A 235
ILE A 435
LEU A 281
THR A 282
THR A 283
 None
 0.88A 3fw3A-2oipA:
undetectable		 3fw3A-2oipA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 HIS A 235
ILE A 435
LEU A 281
THR A 282
THR A 283
 None
 0.89A 3fw3B-2oipA:
undetectable		 3fw3B-2oipA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 VAL A   9
ALA A  11
ASP A  32
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.54A 3hbbA-2oipA:
18.1		 3hbbA-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 VAL A   9
ALA A  11
ASP A  32
THR A  58
SER A  61
TYR A 119
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
None
 0.55A 3hbbB-2oipA:
20.4		 3hbbB-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 VAL A   9
ALA A  11
ASP A  32
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.44A 3hbbC-2oipA:
18.8		 3hbbC-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 VAL A   9
ALA A  11
ASP A  32
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.44A 3hbbD-2oipA:
19.5		 3hbbD-2oipA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
PHE A  36
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.25A 3hj3A-2oipA:
52.8		 3hj3A-2oipA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
LYS A  34
PHE A  36
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 4.1A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.40A 3hj3B-2oipA:
53.0		 3hj3B-2oipA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
PHE A  36
SER A  37
THR A  58
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.36A 3hj3C-2oipA:
51.9		 3hj3C-2oipA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		12 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
PHE A  36
SER A  37
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.43A 3hj3D-2oipA:
50.9		 3hj3D-2oipA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.76A 3ia4A-2oipA:
21.2		 3ia4A-2oipA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.77A 3ia4B-2oipA:
21.3		 3ia4B-2oipA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.71A 3ia4C-2oipA:
21.3		 3ia4C-2oipA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.71A 3ia4D-2oipA:
21.3		 3ia4D-2oipA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
LEU A  33
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.56A 3ix9A-2oipA:
21.8		 3ix9A-2oipA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
LEU A  25
LEU A  33
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.50A 3ix9B-2oipA:
21.7		 3ix9B-2oipA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 8 ARG A 135
SER A 169
PHE A 484
PRO A 481
 None
 1.23A 3jq7B-2oipA:
undetectable		 3jq7B-2oipA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ALA A  11
LEU A  33
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.81A 3jw3A-2oipA:
21.8		 3jw3A-2oipA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ALA A  11
LEU A  25
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.81A 3jw3B-2oipA:
21.8		 3jw3B-2oipA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 11 ALA A  11
LEU A  25
LEU A  33
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.43A 3jw5A-2oipA:
21.5		 3jw5A-2oipA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ALA A  11
LEU A  25
LEU A  33
ILE A  62
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.70A 3jw5B-2oipA:
21.4		 3jw5B-2oipA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 GLY A 364
ALA A 393
ASP A 337
GLY A 339
ASN A 390
 None
 1.32A 3jzjA-2oipA:
undetectable		 3jzjA-2oipA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ALA A 287
GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.2A)
CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.51A 3k2hA-2oipA:
43.6		 3k2hA-2oipA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.57A 3k2hA-2oipA:
43.6		 3k2hA-2oipA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ALA A 287
GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.2A)
CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.51A 3k2hB-2oipA:
44.1		 3k2hB-2oipA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.63A 3k2hB-2oipA:
44.1		 3k2hB-2oipA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.65A 3k2hB-2oipA:
44.1		 3k2hB-2oipA:
46.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.68A 3n0hA-2oipA:
22.9		 3n0hA-2oipA:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
THR A  58
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.31A 3nrrA-2oipA:
44.4		 3nrrA-2oipA:
46.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ALA A 287
GLU A 294
ILE A 315
TRP A 316
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.2A)
CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.56A 3nrrA-2oipA:
44.4		 3nrrA-2oipA:
46.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
THR A  58
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.35A 3nrrB-2oipA:
44.3		 3nrrB-2oipA:
46.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ALA A 287
GLU A 294
ILE A 315
ASN A 319
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.2A)
CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.54A 3nrrB-2oipA:
44.3		 3nrrB-2oipA:
46.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ALA A 287
GLU A 294
ILE A 315
TRP A 316
ASN A 319
ASP A 426
GLY A 430
PHE A 433
TYR A 466
MET A 519
 CB3  A 604 ( 3.2A)
CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.52A 3nrrB-2oipA:
44.3		 3nrrB-2oipA:
46.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 1.08A 3qfxA-2oipA:
22.2		 3qfxA-2oipA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 VAL A   9
ALA A  11
ASP A  32
PHE A  36
THR A  58
SER A  61
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
None
MTX  A 605 ( 4.2A)
 0.27A 3qfxA-2oipA:
22.2		 3qfxA-2oipA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 1.08A 3qfxB-2oipA:
22.2		 3qfxB-2oipA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 VAL A   9
ALA A  11
ASP A  32
PHE A  36
THR A  58
SER A  61
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
None
MTX  A 605 ( 4.2A)
 0.27A 3qfxB-2oipA:
22.2		 3qfxB-2oipA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.44A 3qg2A-2oipA:
40.5		 3qg2A-2oipA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.43A 3qg2B-2oipA:
40.5		 3qg2B-2oipA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.42A 3qgtA-2oipA:
40.3		 3qgtA-2oipA:
40.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A  11
ASP A  32
PHE A  36
SER A  61
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.2A)
 0.91A 3qgtA-2oipA:
40.3		 3qgtA-2oipA:
40.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 1.25A 3qgtB-2oipA:
40.3		 3qgtB-2oipA:
40.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ALA A  11
ASP A  32
PHE A  36
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.34A 3qgtB-2oipA:
40.3		 3qgtB-2oipA:
40.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.58A 3ql0A-2oipA:
21.5		 3ql0A-2oipA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.52A 3ql3A-2oipA:
21.6		 3ql3A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.71A 3s3vA-2oipA:
22.8		 3s3vA-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 9 ALA A  11
LEU A  25
ASP A  32
PHE A  36
SER A  61
ILE A  62
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.65A 3tq8A-2oipA:
22.1		 3tq8A-2oipA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  61
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.71A 3tq9A-2oipA:
21.7		 3tq9A-2oipA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 11 ALA A  11
LEU A  25
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.65A 3tqbA-2oipA:
21.3		 3tqbA-2oipA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ASP A  32
PHE A  36
THR A  58
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.51A 3um5A-2oipA:
40.8		 3um5A-2oipA:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 VAL A  10
PHE A  36
THR A  58
SER A  61
ILE A  62
 NDP  A 606 ( 3.9A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
 1.25A 3um5A-2oipA:
40.8		 3um5A-2oipA:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ASP A  32
PHE A  36
THR A  58
SER A  61
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.53A 3um5B-2oipA:
40.7		 3um5B-2oipA:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 VAL A  10
PHE A  36
THR A  58
SER A  61
ILE A  62
 NDP  A 606 ( 3.9A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
 1.32A 3um5B-2oipA:
40.7		 3um5B-2oipA:
40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ILE A 315
TRP A 316
LEU A 399
HIS A 403
LEU A 429
GLY A 430
PHE A 433
ASN A 434
TYR A 466
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 4.4A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.57A 3uwlB-2oipA:
39.0		 3uwlB-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 TRP A 316
LEU A 399
HIS A 403
LEU A 429
GLY A 430
PHE A 433
ASN A 434
TYR A 466
ALA A 520
 CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 4.4A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.58A 3uwlD-2oipA:
38.0		 3uwlD-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.57A 4cd2A-2oipA:
20.4		 4cd2A-2oipA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.74A 4dfrA-2oipA:
19.8		 4dfrA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.65A 4dfrA-2oipA:
19.8		 4dfrA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.61A 4dfrB-2oipA:
20.4		 4dfrB-2oipA:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
GLY A 430
PHE A 433
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 1.01A 4eb4A-2oipA:
43.9		 4eb4A-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.97A 4eb4A-2oipA:
43.9		 4eb4A-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ILE A 315
TRP A 316
ASP A 426
GLY A 430
ASN A 434
LYS A 516
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
None
CB3  A 604 ( 3.5A)
 0.74A 4eb4A-2oipA:
43.9		 4eb4A-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
ASP A 426
GLY A 430
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.52A 4eb4A-2oipA:
43.9		 4eb4A-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
GLY A 430
PHE A 433
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.98A 4eb4B-2oipA:
43.8		 4eb4B-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.95A 4eb4B-2oipA:
43.8		 4eb4B-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ILE A 315
TRP A 316
ASP A 426
GLY A 430
ASN A 434
LYS A 516
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
None
CB3  A 604 ( 3.5A)
 0.74A 4eb4B-2oipA:
43.8		 4eb4B-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
ASP A 426
GLY A 430
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.52A 4eb4B-2oipA:
43.8		 4eb4B-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
ASP A 426
GLY A 430
ASN A 434
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
 0.56A 4eb4C-2oipA:
40.6		 4eb4C-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.78A 4eb4C-2oipA:
40.6		 4eb4C-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
GLY A 430
PHE A 433
ASN A 434
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
 1.34A 4eb4C-2oipA:
40.6		 4eb4C-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.26A 4eb4C-2oipA:
40.6		 4eb4C-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ASP A 426
GLY A 430
ASN A 434
TYR A 466
LYS A 516
 CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
None
 1.00A 4eb4D-2oipA:
42.1		 4eb4D-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.66A 4eb4D-2oipA:
42.1		 4eb4D-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.19A 4eb4D-2oipA:
42.1		 4eb4D-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ILE A 315
TRP A 316
ASP A 426
GLY A 430
ASN A 434
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
 0.62A 4eb4D-2oipA:
42.1		 4eb4D-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 VAL A   9
ALA A  11
LEU A  25
PHE A  36
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.81A 4eckA-2oipA:
42.9		 4eckA-2oipA:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
PHE A  36
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.81A 4eckB-2oipA:
42.9		 4eckB-2oipA:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.45A 4eilA-2oipA:
44.8		 4eilA-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.50A 4eilB-2oipA:
44.5		 4eilB-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.47A 4eilC-2oipA:
44.8		 4eilC-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 VAL A   9
ALA A  11
ASP A  32
SER A  37
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.29A 4eilD-2oipA:
44.8		 4eilD-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.44A 4eilE-2oipA:
44.7		 4eilE-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.41A 4eilF-2oipA:
44.7		 4eilF-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.46A 4eilG-2oipA:
44.7		 4eilG-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 VAL A   9
ALA A  11
ASP A  32
LYS A  34
SER A  37
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.2A)
 0.67A 4eilH-2oipA:
44.5		 4eilH-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 9 VAL A   9
ALA A  11
ASP A  32
SER A  37
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.35A 4eilH-2oipA:
44.5		 4eilH-2oipA:
44.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.55A 4ej1A-2oipA:
19.8		 4ej1A-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.69A 4ej1B-2oipA:
19.7		 4ej1B-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 8 TYR A 240
LEU A 244
VAL A 247
TYR A 263
 None
 0.70A 4fgzA-2oipA:
undetectable		 4fgzA-2oipA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 8 TYR A 240
LEU A 244
VAL A 247
TYR A 263
 None
 0.69A 4fgzB-2oipA:
undetectable		 4fgzB-2oipA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.57A 4fhbA-2oipA:
20.5		 4fhbA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 GLU A 352
GLY A 351
VAL A 363
PRO A 401
GLY A 343
 None
 1.06A 4fimA-2oipA:
undetectable		 4fimA-2oipA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 LYS A 284
ILE A 315
TRP A 316
LEU A 399
ASP A 426
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.41A 4fogA-2oipA:
37.7		 4fogA-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ILE A 315
TRP A 316
LEU A 399
ASP A 426
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.43A 4fogC-2oipA:
38.3		 4fogC-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 11 LYS A 284
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.45A 4fogD-2oipA:
39.3		 4fogD-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.51A 4foxA-2oipA:
38.0		 4foxA-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.49A 4foxB-2oipA:
37.9		 4foxB-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 GLU A 294
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.54A 4foxC-2oipA:
37.7		 4foxC-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.45A 4foxD-2oipA:
39.2		 4foxD-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 LYS A 284
GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.45A 4foxE-2oipA:
38.0		 4foxE-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.53A 4foxF-2oipA:
37.9		 4foxF-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.43A 4foxG-2oipA:
38.0		 4foxG-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 GLU A 294
ILE A 315
TRP A 316
ASP A 426
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.54A 4foxH-2oipA:
37.8		 4foxH-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.42A 4fqsA-2oipA:
39.2		 4fqsA-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.43A 4fqsB-2oipA:
39.1		 4fqsB-2oipA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ALA A  11
LEU A  25
PHE A  36
SER A  61
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
None
MTX  A 605 ( 4.2A)
 0.69A 4g8zX-2oipA:
21.9		 4g8zX-2oipA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.53A 4gh8A-2oipA:
21.2		 4gh8A-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
ILE A  62
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
None
 0.46A 4gh8B-2oipA:
21.1		 4gh8B-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.60A 4i13A-2oipA:
19.7		 4i13A-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		3 / 3 ASP A  32
ARG A  70
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.22A 4i13A-2oipA:
19.7		 4i13A-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ALA A  11
ASP A  32
LEU A  33
PHE A  36
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.53A 4i1nA-2oipA:
19.7		 4i1nA-2oipA:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 7 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.77A 4iqqA-2oipA:
40.5		 4iqqA-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 7 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.18A 4iqqA-2oipA:
40.5		 4iqqA-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.76A 4iqqB-2oipA:
39.5		 4iqqB-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.70A 4iqqC-2oipA:
39.7		 4iqqC-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.71A 4iqqD-2oipA:
39.4		 4iqqD-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.19A 4iqqD-2oipA:
39.4		 4iqqD-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 LYS A 284
ILE A 315
ASP A 426
GLY A 430
TYR A 466
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 1.05A 4iqqD-2oipA:
39.4		 4iqqD-2oipA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.57A 4kebB-2oipA:
22.5		 4kebB-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.56A 4kfjB-2oipA:
22.7		 4kfjB-2oipA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.56A 4kjjA-2oipA:
20.5		 4kjjA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 4 ASP A  32
LEU A  33
ARG A  70
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.36A 4kjjA-2oipA:
20.5		 4kjjA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.56A 4kjkA-2oipA:
21.2		 4kjkA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 4 ASP A  32
LEU A  33
ARG A  70
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.37A 4kjkA-2oipA:
21.2		 4kjkA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.49A 4kjlA-2oipA:
21.0		 4kjlA-2oipA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A  11
ASP A  32
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 1.18A 4km0A-2oipA:
20.0		 4km0A-2oipA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ALA A  11
ASP A  32
PHE A  36
THR A  58
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 0.57A 4km0A-2oipA:
20.0		 4km0A-2oipA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
PHE A  36
THR A  58
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 0.54A 4km0B-2oipA:
20.4		 4km0B-2oipA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
PHE A  36
THR A  58
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.66A 4km2A-2oipA:
20.3		 4km2A-2oipA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
PHE A  36
THR A  58
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 0.52A 4km2A-2oipA:
20.3		 4km2A-2oipA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
PHE A  36
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.51A 4km2B-2oipA:
19.9		 4km2B-2oipA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
LYS A  34
SER A  37
ILE A  62
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.55A 4ky8A-2oipA:
51.7		 4ky8A-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.57A 4ky8A-2oipA:
51.7		 4ky8A-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
LYS A  34
SER A  37
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.53A 4ky8B-2oipA:
51.8		 4ky8B-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.50A 4ky8B-2oipA:
51.8		 4ky8B-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
LYS A  34
SER A  37
SER A  61
ILE A  62
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.65A 4ky8C-2oipA:
51.5		 4ky8C-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.45A 4ky8C-2oipA:
51.5		 4ky8C-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
LYS A  34
SER A  37
ILE A  62
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.48A 4ky8D-2oipA:
51.7		 4ky8D-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.46A 4ky8D-2oipA:
51.7		 4ky8D-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
LYS A  34
SER A  37
ILE A  62
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.2A)
 0.52A 4ky8E-2oipA:
51.6		 4ky8E-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
ILE A  62
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.44A 4ky8E-2oipA:
51.6		 4ky8E-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 VAL A   9
ALA A  11
ASP A  32
SER A  37
THR A  58
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.48A 4kyaA-2oipA:
44.1		 4kyaA-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.37A 4kyaB-2oipA:
44.3		 4kyaB-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 10 ALA A  11
ASP A  32
SER A  37
LEU A  52
ARG A  70
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
None
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 1.49A 4kyaC-2oipA:
42.8		 4kyaC-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.51A 4kyaC-2oipA:
42.8		 4kyaC-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.40A 4kyaD-2oipA:
43.0		 4kyaD-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 VAL A   9
ALA A  11
ASP A  32
SER A  37
THR A  58
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.51A 4kyaE-2oipA:
44.1		 4kyaE-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.39A 4kyaF-2oipA:
44.0		 4kyaF-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 VAL A   9
ALA A  11
ASP A  32
SER A  37
THR A  58
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.50A 4kyaG-2oipA:
44.1		 4kyaG-2oipA:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 VAL A   9
ALA A  11
ASP A  32
SER A  37
LEU A  67
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.41A 4kyaH-2oipA:
44.4		 4kyaH-2oipA:
44.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A 388
TYR A 408
LEU A 445
LEU A 416
GLY A 454
 None
 1.13A 4l9qB-2oipA:
undetectable		 4l9qB-2oipA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
PHE A  36
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
None
 0.61A 4m2xA-2oipA:
21.0		 4m2xA-2oipA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 ALA A  11
ASP A  32
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.59A 4m2xC-2oipA:
20.8		 4m2xC-2oipA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.49A 4m6kA-2oipA:
23.1		 4m6kA-2oipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.50A 4nx6A-2oipA:
21.6		 4nx6A-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.57A 4nx7A-2oipA:
21.7		 4nx7A-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.51A 4p3qA-2oipA:
21.6		 4p3qA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 5 ASP A  32
LEU A  33
ARG A  70
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.54A 4p3qA-2oipA:
21.6		 4p3qA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.56A 4p3rA-2oipA:
21.6		 4p3rA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		3 / 3 ASP A  32
ARG A  70
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.23A 4p3rA-2oipA:
21.6		 4p3rA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
ASP A  32
LEU A  33
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.51A 4p66A-2oipA:
21.6		 4p66A-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ASP A  32
PHE A  36
SER A  61
ILE A  62
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.56A 4p68A-2oipA:
21.5		 4p68A-2oipA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
 0.57A 4pssA-2oipA:
undetectable		 4pssA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.50A 4pstA-2oipA:
undetectable		 4pstA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.56A 4psyA-2oipA:
21.6		 4psyA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.59A 4pthA-2oipA:
21.4		 4pthA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		3 / 3 ASP A  32
LEU A  33
PHE A  36
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
 0.11A 4pthA-2oipA:
21.4		 4pthA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.46A 4ptjA-2oipA:
21.5		 4ptjA-2oipA:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 VAL A   9
ALA A  11
ASP A  32
LYS A  34
SER A  37
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.69A 4q0dA-2oipA:
52.2		 4q0dA-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.24A 4q0dA-2oipA:
52.2		 4q0dA-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 VAL A   9
ALA A  11
ASP A  32
LYS A  34
SER A  37
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.68A 4q0dB-2oipA:
52.2		 4q0dB-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.25A 4q0dB-2oipA:
52.2		 4q0dB-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ALA A  11
ASP A  32
LYS A  34
SER A  37
SER A  61
LEU A  67
ARG A  70
CYH A 113
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
None
MTX  A 605 ( 4.2A)
 0.80A 4q0dC-2oipA:
52.1		 4q0dC-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
LEU A  67
ARG A  70
CYH A 113
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
None
MTX  A 605 ( 4.2A)
 0.47A 4q0dC-2oipA:
52.1		 4q0dC-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ALA A  11
ASP A  32
LYS A  34
SER A  37
SER A  61
LEU A  67
ARG A  70
CYH A 113
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
None
MTX  A 605 ( 4.2A)
 0.81A 4q0dD-2oipA:
52.2		 4q0dD-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
SER A  61
LEU A  67
ARG A  70
CYH A 113
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
None
MTX  A 605 ( 4.2A)
 0.47A 4q0dD-2oipA:
52.2		 4q0dD-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 VAL A   9
ALA A  11
ASP A  32
LYS A  34
SER A  37
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.68A 4q0dE-2oipA:
52.2		 4q0dE-2oipA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 VAL A   9
ALA A  11
LEU A  25
ASP A  32
LEU A  33
SER A  37
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.24A 4q0dE-2oipA:
52.2		 4q0dE-2oipA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 GLY A 305
ILE A 341
GLY A 320
VAL A 313
ILE A 315
 None
None
None
None
CB3  A 604 ( 3.7A)
 0.84A 4q5mA-2oipA:
undetectable		 4q5mA-2oipA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.51A 4qi9A-2oipA:
19.0		 4qi9A-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.57A 4qi9A-2oipA:
19.0		 4qi9A-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.63A 4qi9B-2oipA:
19.4		 4qi9B-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.65A 4qi9B-2oipA:
19.4		 4qi9B-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 11 ALA A  11
ASP A  32
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.52A 4qi9C-2oipA:
18.7		 4qi9C-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 11 ALA A  11
ASP A  32
LYS A  38
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
None
None
MTX  A 605 ( 4.2A)
 1.28A 4qi9C-2oipA:
18.7		 4qi9C-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 11 ALA A  11
ASP A  32
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.66A 4qi9C-2oipA:
18.7		 4qi9C-2oipA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.52A 4qleA-2oipA:
20.7		 4qleA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 12 ALA A  11
ASP A  32
PHE A  36
THR A  58
LEU A  52
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 1.48A 4qleA-2oipA:
20.7		 4qleA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.59A 4qleB-2oipA:
20.8		 4qleB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 11 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.61A 4qleB-2oipA:
20.8		 4qleB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 11 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.54A 4qlfA-2oipA:
17.6		 4qlfA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.59A 4qlgA-2oipA:
20.8		 4qlgA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.50A 4qlgB-2oipA:
20.4		 4qlgB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.53A 4rgcA-2oipA:
21.7		 4rgcA-2oipA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.53A 4x5fA-2oipA:
20.3		 4x5fA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.52A 4x5fB-2oipA:
20.7		 4x5fB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
ASP A  32
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.48A 4x5gA-2oipA:
20.4		 4x5gA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.63A 4x5gB-2oipA:
20.9		 4x5gB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.65A 4x5hA-2oipA:
20.3		 4x5hA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.69A 4x5iA-2oipA:
20.3		 4x5iA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.56A 4x5jA-2oipA:
20.3		 4x5jA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 SER A 437
TYR A 438
PHE A 298
GLU A 294
 None
None
None
CB3  A 604 ( 3.8A)
 1.41A 4xzkA-2oipA:
undetectable		 4xzkA-2oipA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
None
MTX  A 605 ( 4.2A)
 0.44A 5e8qA-2oipA:
20.0		 5e8qA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		3 / 3 ASP A  32
LEU A  67
ARG A  70
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
 0.47A 5e8qA-2oipA:
20.0		 5e8qA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.58A 5e8qB-2oipA:
20.5		 5e8qB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.56A 5eajA-2oipA:
20.1		 5eajA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.56A 5eajB-2oipA:
20.4		 5eajB-2oipA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 11 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.65A 5fctA-2oipA:
44.8		 5fctA-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 LYS A 284
VAL A 286
ILE A 315
TRP A 316
LEU A 399
CYH A 402
LEU A 429
TYR A 466
MET A 517
MET A 519
ALA A 520
 CB3  A 604 ( 4.7A)
None
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 3.0A)
CB3  A 604 ( 4.4A)
UMP  A 603 ( 4.3A)
None
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.53A 5fctB-2oipA:
44.9		 5fctB-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		3 / 3 ASN A 319
ASP A 426
GLY A 430
 CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
 0.34A 5fctB-2oipA:
44.9		 5fctB-2oipA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 ILE A 315
ASP A 426
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.54A 5h3aA-2oipA:
41.0		 5h3aA-2oipA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 ILE A 315
ASP A 426
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.42A 5h3aB-2oipA:
19.9		 5h3aB-2oipA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.50A 5hi6A-2oipA:
20.5		 5hi6A-2oipA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.60A 5hi6A-2oipA:
20.5		 5hi6A-2oipA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
ASP A  32
LEU A  33
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.58A 5hi6B-2oipA:
21.0		 5hi6B-2oipA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
ASP A  32
LEU A  33
SER A  61
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.86A 5hi6B-2oipA:
21.0		 5hi6B-2oipA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.50A 5j7wC-2oipA:
38.7		 5j7wC-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 GLU A 294
ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.51A 5j7wD-2oipA:
38.4		 5j7wD-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ALA A 122
ILE A  53
GLY A  55
VAL A  10
ILE A   8
 None
None
NDP  A 606 ( 3.2A)
NDP  A 606 ( 3.9A)
None
 1.12A 5kr0A-2oipA:
undetectable		 5kr0A-2oipA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 HIS A 235
LEU A 281
THR A 282
THR A 283
 None
 0.92A 5m78A-2oipA:
undetectable		 5m78A-2oipA:
8.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 7 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.76A 5nooA-2oipA:
40.4		 5nooA-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 7 ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.77A 5nooB-2oipA:
40.1		 5nooB-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 6 ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.77A 5nooC-2oipA:
20.2		 5nooC-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.78A 5nooD-2oipA:
20.3		 5nooD-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.25A 5nooD-2oipA:
20.3		 5nooD-2oipA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A 436
PHE A 499
ILE A 296
ILE A 299
ALA A 439
 None
 1.22A 5nukA-2oipA:
undetectable		 5nukA-2oipA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ALA A  11
ASP A  32
LEU A  33
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 4.2A)
 0.51A 5uihA-2oipA:
19.6		 5uihA-2oipA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.61A 5ujxA-2oipA:
20.0		 5ujxA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.58A 5ujxB-2oipA:
20.4		 5ujxB-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 4 LEU A 420
LEU A 456
SER A 437
ALA A 439
 None
 1.03A 5uunA-2oipA:
undetectable		 5uunA-2oipA:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 GLU A 294
ILE A 315
ASP A 426
LEU A 429
GLY A 430
THR A 514
MET A 517
ALA A 520
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
None
None
CB3  A 604 ( 4.0A)
 0.87A 5x5qB-2oipA:
43.4		 5x5qB-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 GLU A 294
ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
TYR A 466
THR A 514
MET A 517
 CB3  A 604 ( 3.8A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
None
None
 0.72A 5x5qB-2oipA:
43.4		 5x5qB-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ILE A 315
TRP A 316
ASP A 426
LEU A 429
GLY A 430
TYR A 466
THR A 514
MET A 517
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
None
None
CB3  A 604 ( 3.5A)
 0.81A 5x5qB-2oipA:
43.4		 5x5qB-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 7 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.66A 5x5qC-2oipA:
41.3		 5x5qC-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.64A 5x5qD-2oipA:
19.7		 5x5qD-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 6 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.63A 5x5qE-2oipA:
41.4		 5x5qE-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 8 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.64A 5x5qF-2oipA:
41.4		 5x5qF-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
LEU A 429
GLY A 430
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.55A 5x66A-2oipA:
43.1
5x66B-2oipA:
20.0		 5x66A-2oipA:
38.51
5x66B-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 9 ILE A 315
ASP A 426
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 1.13A 5x66C-2oipA:
43.3		 5x66C-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 9 ILE A 315
ASP A 426
LEU A 429
GLY A 430
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.55A 5x66C-2oipA:
43.3		 5x66C-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ILE A 315
ASP A 426
GLY A 430
ASN A 434
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.48A 5x66D-2oipA:
43.4		 5x66D-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 ILE A 315
ASP A 426
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 1.08A 5x66D-2oipA:
43.4		 5x66D-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
ASP A 426
GLY A 430
PHE A 433
TYR A 466
MET A 519
ALA A 520
VAL A 521
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
None
 1.27A 5x66F-2oipA:
43.5		 5x66F-2oipA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 LYS A 284
ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
THR A 514
MET A 519
ALA A 520
VAL A 521
 CB3  A 604 ( 4.7A)
CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
None
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
None
 0.86A 5x66F-2oipA:
43.5		 5x66F-2oipA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 12 PRO A 511
THR A 282
GLU A 237
HIS A 235
THR A 226
 None
 1.46A 5xiqC-2oipA:
2.4		 5xiqC-2oipA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
ARG A  70
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
None
MTX  A 605 ( 4.2A)
 0.49A 5z6fA-2oipA:
21.6		 5z6fA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.51A 5z6jA-2oipA:
21.8		 5z6jA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ALA A  11
LEU A  33
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.58A 5z6kA-2oipA:
21.7		 5z6kA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 9 ALA A  11
ASP A  32
LEU A  33
ILE A  62
ARG A  70
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 3.1A)
 0.72A 5z6lA-2oipA:
21.6		 5z6lA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 11 ALA A  11
ASP A  32
LEU A  33
PHE A  36
LEU A  67
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 4.2A)
 0.91A 5z6mA-2oipA:
21.0		 5z6mA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		6 / 11 ALA A  11
ASP A  32
LEU A  33
PHE A  36
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 4.1A)
None
MTX  A 605 ( 4.2A)
 0.75A 5z6mA-2oipA:
21.0		 5z6mA-2oipA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 VAL A   9
ALA A  11
ASP A  32
PHE A  36
THR A  58
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 0.34A 6aogA-2oipA:
44.6		 6aogA-2oipA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 10 VAL A   9
ALA A  11
ASP A  32
PHE A  36
THR A  58
TYR A 119
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
None
MTX  A 605 ( 4.2A)
 0.38A 6aogB-2oipA:
44.7		 6aogB-2oipA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A 122
ILE A  53
GLY A  55
VAL A  10
ILE A   8
 None
None
NDP  A 606 ( 3.2A)
NDP  A 606 ( 3.9A)
None
 1.02A 6dj2A-2oipA:
undetectable		 6dj2A-2oipA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		5 / 10 ALA A 436
LEU A 280
LEU A 281
TYR A 240
VAL A 286
 None
 1.42A 6g2pB-2oipA:
undetectable		 6g2pB-2oipA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		4 / 5 ASN A 256
GLY A 428
HIS A 464
ASP A 462
 None
None
UMP  A 603 ( 4.1A)
None
 1.13A 6gh9A-2oipA:
undetectable		 6gh9A-2oipA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
LEU A 399
LEU A 429
GLY A 430
PHE A 433
ASN A 434
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
 0.56A 6qxsB-2oipA:
37.8		 6qxsB-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		8 / 12 ILE A 315
TRP A 316
LEU A 399
ASP A 426
LEU A 429
GLY A 430
ASN A 434
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 4.0A)
 0.64A 6qxsD-2oipA:
37.8		 6qxsD-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 12 ILE A 315
TRP A 316
LEU A 399
HIS A 403
LEU A 429
GLY A 430
PHE A 433
TYR A 466
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 4.4A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.50A 6qyaB-2oipA:
37.6		 6qyaB-2oipA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 12 ILE A 315
TRP A 316
LEU A 399
HIS A 403
LEU A 429
GLY A 430
PHE A 433
ASN A 434
TYR A 466
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 4.4A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 4.0A)
 0.54A 6qyaD-2oipA:
37.5		 6qyaD-2oipA:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
ASN A 434
TYR A 466
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
UMP  A 603 ( 4.3A)
CB3  A 604 ( 3.5A)
 0.75A 6r2eA-2oipA:
44.5		 6r2eA-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 10 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
ASN A 434
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
 0.70A 6r2eB-2oipA:
44.4		 6r2eB-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 10 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
ASN A 434
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
 0.77A 6r2eC-2oipA:
44.6		 6r2eC-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		9 / 10 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
ASN A 434
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
 0.67A 6r2eD-2oipA:
44.4		 6r2eD-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ILE A 315
TRP A 316
ASN A 319
TYR A 342
LEU A 399
LEU A 429
GLY A 430
PHE A 433
ASN A 434
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
None
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.63A 6r2eE-2oipA:
44.4		 6r2eE-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 11 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
ASN A 434
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.68A 6r2eF-2oipA:
44.5		 6r2eF-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		10 / 11 ILE A 315
TRP A 316
ASN A 319
LEU A 399
ASP A 426
LEU A 429
GLY A 430
PHE A 433
ASN A 434
MET A 519
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
 0.70A 6r2eG-2oipA:
44.5		 6r2eG-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		11 / 12 ILE A 315
TRP A 316
ASN A 319
TYR A 342
LEU A 399
ASP A 426
LEU A 429
GLY A 430
ASN A 434
MET A 519
ALA A 520
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 4.3A)
None
None
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 2.7A)
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.83A 6r2eH-2oipA:
44.4		 6r2eH-2oipA:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  67
TYR A 119
THR A 134
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.1A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
None
MTX  A 605 ( 4.2A)
 0.48A 7dfrA-2oipA:
21.5		 7dfrA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR
(Cryptosporidium
hominis) 		3 / 3 ASP A  32
LEU A  33
ARG A  70
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.1A)
 0.38A 7dfrA-2oipA:
21.5		 7dfrA-2oipA:
16.67