SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ok0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 117
PRO H 149
THR H 116
PRO H 118
 None
 1.33A 1dsdC-2ok0H:
undetectable		 1dsdC-2ok0H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 117
PRO H 149
THR H 116
PRO H 118
 None
 1.33A 1dsdC-2ok0H:
undetectable		 1dsdC-2ok0H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		5 / 11 LEU H 140
ALA H 130
GLN H 133
THR H 199
PRO H 202
 None
 1.29A 3qelA-2ok0H:
undetectable
3qelB-2ok0H:
undetectable		 3qelA-2ok0H:
18.97
3qelB-2ok0H:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.40A 4m7kH-2ok0H:
21.8		 4m7kH-2ok0H:
64.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-2ok0H:
undetectable		 4o2bC-2ok0H:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
ALA H 130
GLN H 133
THR H 199
PRO H 202
 None
 1.33A 5ewjC-2ok0H:
undetectable
5ewjD-2ok0H:
undetectable		 5ewjC-2ok0H:
19.10
5ewjD-2ok0H:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.58A 5eypA-2ok0H:
undetectable		 5eypA-2ok0H:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		4 / 6 LEU H  37
MET H  80
THR H  68
LEU H  69
 None
 1.09A 5x1fA-2ok0H:
undetectable
5x1fJ-2ok0H:
undetectable		 5x1fA-2ok0H:
16.02
5x1fJ-2ok0H:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2ok0 FAB ED10 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.52A 5xiwC-2ok0H:
undetectable		 5xiwC-2ok0H:
15.21