SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2okc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 THR A  20
LEU A  22
GLY A  28
TYR A  32
None
1.25A 1gtiF-2okcA:
0.8
1gtiF-2okcA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 LEU A 229
TYR A 228
ILE A 133
TRP A 122
LEU A 123
None
1.20A 1mrqA-2okcA:
undetectable
1mrqA-2okcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY A 180
GLY A 182
GLY A 183
VAL A 219
ASN A 284
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.5A)
SAM  A 500 (-3.2A)
None
None
0.69A 1n2xB-2okcA:
11.9
1n2xB-2okcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY A 180
GLY A 182
GLY A 183
VAL A 219
GLY A 150
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.5A)
SAM  A 500 (-3.2A)
None
None
0.87A 1n2xB-2okcA:
11.9
1n2xB-2okcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A  38
TYR A  79
GLN A  35
SER A 224
None
1.18A 1nx9A-2okcA:
undetectable
1nx9A-2okcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A  38
TYR A  79
GLN A  35
SER A 224
None
1.19A 1nx9B-2okcA:
undetectable
1nx9B-2okcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A  38
TYR A  79
GLN A  35
SER A 224
None
1.19A 1nx9C-2okcA:
undetectable
1nx9C-2okcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A  38
TYR A  79
GLN A  35
SER A 224
None
1.19A 1nx9D-2okcA:
undetectable
1nx9D-2okcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU A 325
HIS A 331
ILE A 333
PHE A 364
ILE A 417
None
GOL  A 501 (-3.7A)
None
None
None
1.14A 1ot7B-2okcA:
undetectable
1ot7B-2okcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 THR A 221
PRO A 217
TYR A  38
ILE A  96
LEU A  83
None
1.43A 1z9hA-2okcA:
undetectable
1z9hA-2okcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 THR A 221
PRO A 217
TYR A  38
ILE A  96
LEU A  83
None
1.44A 1z9hB-2okcA:
undetectable
1z9hB-2okcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 THR A 221
PRO A 217
TYR A  38
ILE A  96
LEU A  83
None
1.43A 1z9hC-2okcA:
undetectable
1z9hC-2okcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 THR A 154
ALA A 178
ASP A 243
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.3A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
1.06A 2admA-2okcA:
20.7
2admA-2okcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 THR A 154
ALA A 178
ASP A 243
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.3A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
1.00A 2admB-2okcA:
20.8
2admB-2okcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 4 THR A 154
THR A 181
ASP A 214
ASP A 243
SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
0.41A 2f8lA-2okcA:
6.8
2f8lA-2okcA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 ARG A 335
ASP A 366
THR A 428
ASP A 308
None
1.23A 2j2pE-2okcA:
undetectable
2j2pF-2okcA:
undetectable
2j2pE-2okcA:
20.22
2j2pF-2okcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU A  83
ALA A 100
TYR A  97
LEU A  42
TYR A  79
None
1.24A 2japA-2okcA:
6.1
2japA-2okcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU A  83
ALA A 100
TYR A  97
LEU A  42
TYR A  79
None
1.22A 2japB-2okcA:
6.2
2japB-2okcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU A  83
ALA A 100
TYR A  97
LEU A  42
TYR A  79
None
1.23A 2japC-2okcA:
5.8
2japC-2okcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU A  83
ALA A 100
TYR A  97
LEU A  42
TYR A  79
None
1.22A 2japD-2okcA:
6.1
2japD-2okcA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 12 ALA A 178
GLY A 183
VAL A 220
SER A 244
ARG A 265
PHE A 288
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
None
SAM  A 500 (-3.8A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.8A)
1.37A 2okcA-2okcA:
68.0
2okcA-2okcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 12 TYR A 152
ALA A 178
GLY A 182
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-4.7A)
SAM  A 500 (-3.4A)
SAM  A 500 ( 4.5A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.92A 2okcA-2okcA:
68.0
2okcA-2okcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
12 / 12 TYR A 152
ILE A 159
ALA A 178
GLY A 180
GLY A 183
THR A 216
VAL A 219
SER A 244
ASN A 259
PRO A 261
ARG A 265
PHE A 288
SAM  A 500 (-4.7A)
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.2A)
SAM  A 500 (-4.0A)
None
SAM  A 500 (-3.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.8A)
0.10A 2okcA-2okcA:
68.0
2okcA-2okcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 6 THR A 154
ARG A 156
THR A 181
ASP A 214
ASN A 215
ASP A 243
SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.1A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
0.07A 2okcA-2okcA:
68.0
2okcA-2okcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 12 TYR A 152
ALA A 178
GLY A 182
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-4.7A)
SAM  A 500 (-3.4A)
SAM  A 500 ( 4.5A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.95A 2okcB-2okcA:
62.3
2okcB-2okcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
12 / 12 TYR A 152
ILE A 159
ALA A 178
GLY A 180
GLY A 183
ASN A 215
VAL A 219
SER A 244
ASN A 259
PRO A 261
ARG A 265
PHE A 288
SAM  A 500 (-4.7A)
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.2A)
None
SAM  A 500 (-3.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.8A)
0.16A 2okcB-2okcA:
62.3
2okcB-2okcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 6 THR A 154
ARG A 156
THR A 181
ASP A 214
THR A 216
ASP A 243
SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.1A)
SAM  A 500 (-2.9A)
SAM  A 500 (-4.0A)
SAM  A 500 (-3.3A)
0.16A 2okcB-2okcA:
62.3
2okcB-2okcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 GLU A 172
ALA A 188
LEU A 185
THR A 187
None
1.09A 2roxB-2okcA:
undetectable
2roxB-2okcA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 7 ALA A 178
GLY A 180
ASP A 214
ASP A 243
ARG A 265
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
SAM  A 500 ( 4.6A)
1.10A 2uyqA-2okcA:
8.1
2uyqA-2okcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ALA A 178
GLY A 180
ASP A 214
VAL A 219
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
None
0.64A 2uyqA-2okcA:
8.1
2uyqA-2okcA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
9 / 12 ILE A 159
ALA A 178
GLY A 180
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.71A 2y7hB-2okcA:
38.7
2y7hB-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
8 / 12 THR A 154
ALA A 178
THR A 181
GLY A 182
LEU A 245
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.5A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
1.06A 2y7hB-2okcA:
38.7
2y7hB-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
9 / 12 THR A 154
ILE A 159
ALA A 178
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.73A 2y7hB-2okcA:
38.7
2y7hB-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
9 / 12 ILE A 159
ALA A 178
GLY A 180
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.71A 2y7hC-2okcA:
38.8
2y7hC-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
8 / 12 THR A 154
ALA A 178
THR A 181
GLY A 182
LEU A 245
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.5A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
1.06A 2y7hC-2okcA:
38.8
2y7hC-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
9 / 12 THR A 154
ILE A 159
ALA A 178
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.74A 2y7hC-2okcA:
38.8
2y7hC-2okcA:
37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 LEU A  18
GLN A  25
THR A  21
THR A 115
None
1.30A 2zj0B-2okcA:
4.4
2zj0B-2okcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 LEU A  18
GLN A  25
THR A  21
THR A 115
None
1.24A 2zj0C-2okcA:
5.1
2zj0C-2okcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 4 LEU A  18
GLN A  25
THR A  21
THR A 115
None
1.22A 2zj0D-2okcA:
2.4
2zj0D-2okcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 LEU A  18
GLN A  25
THR A  21
THR A 115
None
1.23A 3ce6B-2okcA:
4.1
3ce6B-2okcA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 ILE A 239
ARG A 156
THR A 181
GLU A 135
None
SAM  A 500 (-3.1A)
SAM  A 500 (-3.1A)
None
1.29A 3ny4A-2okcA:
undetectable
3ny4A-2okcA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 GLY A 180
ASP A 214
ASP A 243
SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
0.45A 3ou7C-2okcA:
9.4
3ou7C-2okcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 PRO A 177
LEU A 185
ILE A 256
MET A 292
None
0.94A 3u5jA-2okcA:
undetectable
3u5jA-2okcA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 PRO A 177
LEU A 185
ILE A 256
MET A 292
None
0.89A 3u5kA-2okcA:
undetectable
3u5kA-2okcA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 PRO A 177
LEU A 185
ILE A 256
MET A 292
None
0.84A 3u5kD-2okcA:
undetectable
3u5kD-2okcA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 LEU A 123
MET A 125
ASP A 128
None
0.74A 3v5wA-2okcA:
undetectable
3v5wA-2okcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 GLY A 180
ASP A 214
ASP A 243
ASN A 259
PRO A 261
SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
0.75A 3v8vB-2okcA:
undetectable
3v8vB-2okcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU A 296
THR A 359
ILE A 256
ALA A 258
LEU A 324
None
1.37A 3vw1B-2okcA:
undetectable
3vw1B-2okcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ALA A 302
ALA A 258
VAL A 304
ALA A 188
VAL A 174
None
1.05A 4df3A-2okcA:
10.7
4df3A-2okcA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ALA A 302
ALA A 258
VAL A 304
ALA A 188
VAL A 174
None
1.04A 4df3B-2okcA:
10.7
4df3B-2okcA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 ASP A 105
ASN A 102
THR A  34
GLY A  28
None
0.92A 4fo4A-2okcA:
undetectable
4fo4A-2okcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 HIS A 384
VAL A 350
LEU A 336
None
0.69A 4m2vA-2okcA:
undetectable
4m2vA-2okcA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 4 ASP A 176
GLY A 180
ASP A 214
ASP A 243
SAM  A 500 ( 4.9A)
SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
0.32A 5e72A-2okcA:
15.0
5e72A-2okcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 VAL A 304
LEU A 306
ALA A 258
LEU A 296
None
0.66A 5jq7A-2okcA:
undetectable
5jq7A-2okcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 8 ALA A 302
LEU A 289
LEU A 306
LEU A 330
LEU A 324
None
1.39A 5jqbA-2okcA:
undetectable
5jqbB-2okcA:
undetectable
5jqbA-2okcA:
20.44
5jqbB-2okcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 LEU A 227
ILE A 133
TRP A 122
LEU A  40
MET A  44
None
1.44A 5ljdA-2okcA:
undetectable
5ljdA-2okcA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 12 ALA A 178
GLY A 180
THR A 181
GLY A 182
LEU A 245
PHE A 288
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.5A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-4.8A)
0.97A 5ybbA-2okcA:
35.6
5ybbA-2okcA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 12 ALA A 178
GLY A 180
THR A 181
LEU A 245
ASN A 259
PHE A 288
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.8A)
0.71A 5ybbA-2okcA:
35.6
5ybbA-2okcA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
8 / 12 THR A 154
ARG A 156
ASP A 176
THR A 181
LEU A 245
ASN A 259
PRO A 261
PHE A 288
SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.9A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.68A 5ybbB-2okcA:
35.6
5ybbB-2okcA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ALA A 178
GLY A 183
ASP A 243
ARG A 265
PRO A 261
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.1A)
1.10A 5zvgA-2okcA:
11.3
5zvgA-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ALA A 178
GLY A 183
ASP A 243
PRO A 261
PHE A 288
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.79A 5zvgA-2okcA:
11.3
5zvgA-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ALA A 178
GLY A 183
ASP A 243
ARG A 265
PRO A 261
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.1A)
1.10A 5zvgB-2okcA:
10.3
5zvgB-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ALA A 178
GLY A 183
ASP A 243
PRO A 261
PHE A 288
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
0.78A 5zvgB-2okcA:
10.3
5zvgB-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ILE A 256
VAL A 174
ALA A 188
THR A 187
None
0.71A 6cduC-2okcA:
undetectable
6cduD-2okcA:
undetectable
6cduC-2okcA:
19.91
6cduD-2okcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 ILE A 256
VAL A 174
ALA A 188
THR A 187
None
0.74A 6cduD-2okcA:
undetectable
6cduE-2okcA:
undetectable
6cduD-2okcA:
19.91
6cduE-2okcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ALA A 188
THR A 187
ILE A 256
VAL A 174
None
0.77A 6cduF-2okcA:
undetectable
6cduJ-2okcA:
undetectable
6cduF-2okcA:
19.91
6cduJ-2okcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 9 LEU A 306
VAL A 304
PHE A 328
SER A 354
LEU A 296
ILE A 256
None
1.49A 6fdyU-2okcA:
undetectable
6fdyU-2okcA:
22.25