SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2okk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 4 THR A 391
LEU A 407
VAL A 409
LEU A 414
 None
 0.98A 1fbmB-2okkA:
undetectable		 1fbmB-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 4 THR A 107
LEU A 111
VAL A 114
LEU A 118
 None
 0.86A 1fbmD-2okkA:
undetectable		 1fbmD-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 5 THR A 107
LEU A 111
VAL A 114
LEU A 118
 None
 0.72A 1fbmE-2okkA:
undetectable		 1fbmE-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 PHE A 330
LEU A 285
ALA A 275
GLY A 288
LEU A 270
 None
 1.27A 1kglA-2okkA:
undetectable		 1kglA-2okkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 GLY A 337
VAL A 384
LEU A 347
LEU A 371
LEU A 381
 None
 1.07A 1mx1F-2okkA:
undetectable		 1mx1F-2okkA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 4 THR A 107
LEU A 111
VAL A 114
LEU A 118
 None
 0.87A 1mz9D-2okkA:
undetectable		 1mz9D-2okkA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 GLY A 370
GLY A 369
VAL A 390
LEU A 381
SER A 382
 None
 0.89A 1ya4C-2okkA:
2.1		 1ya4C-2okkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 4 LEU A 182
SER A 405
ASP A 364
ASP A 345
 ABU  A 585 ( 3.9A)
LLP  A 396 ( 4.9A)
LLP  A 396 ( 2.6A)
None
 1.35A 2br4B-2okkA:
2.5		 2br4B-2okkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 LEU A 371
LEU A 381
ALA A 366
THR A 391
MET A 361
 None
None
LLP  A 396 ( 3.5A)
None
None
 1.26A 2v0mC-2okkA:
undetectable		 2v0mC-2okkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		3 / 3 ARG A 177
GLU A 576
TYR A 480
 None
 0.93A 3k37B-2okkA:
undetectable		 3k37B-2okkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 6 ILE A 245
ALA A 244
ALA A 366
THR A 391
 None
LLP  A 396 ( 3.3A)
LLP  A 396 ( 3.5A)
None
 0.99A 3mdrB-2okkA:
undetectable		 3mdrB-2okkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 GLY A 337
ALA A 336
ASP A 364
VAL A 384
 None
None
LLP  A 396 ( 2.6A)
None
 0.68A 3t3cA-2okkA:
undetectable		 3t3cA-2okkA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 GLN A 500
GLY A 337
GLY A 342
SER A 281
ALA A 336
 None
None
None
GOL  A 587 (-3.9A)
None
 1.37A 3t7sC-2okkA:
undetectable		 3t7sC-2okkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 11 VAL A 363
PHE A 344
SER A 382
LEU A 372
VAL A 390
 None
 1.39A 4eilA-2okkA:
2.0		 4eilA-2okkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 10 VAL A 363
PHE A 344
SER A 382
LEU A 372
VAL A 390
 None
 1.42A 4eilB-2okkA:
2.0		 4eilB-2okkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 11 VAL A 363
PHE A 344
SER A 382
LEU A 372
VAL A 390
 None
 1.40A 4eilC-2okkA:
2.0		 4eilC-2okkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 11 VAL A 363
PHE A 344
SER A 382
LEU A 372
VAL A 390
 None
 1.41A 4eilE-2okkA:
2.0		 4eilE-2okkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 8 ARG A 177
ASN A 563
GLY A 185
ASP A 187
THR A 567
 None
 1.49A 4eyrB-2okkA:
undetectable		 4eyrB-2okkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		3 / 3 LYS A 323
LEU A 320
ALA A 322
 None
 0.70A 4ikiA-2okkA:
undetectable		 4ikiA-2okkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 10 TRP A 392
ALA A 366
ASP A 364
THR A 502
THR A 391
 None
LLP  A 396 ( 3.5A)
LLP  A 396 ( 2.6A)
None
None
 1.24A 4km0A-2okkA:
undetectable		 4km0A-2okkA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 11 GLY A 288
ALA A 289
ILE A 253
THR A 277
VAL A 299
 None
None
None
GOL  A 587 ( 4.9A)
None
 0.97A 4l1aA-2okkA:
undetectable		 4l1aA-2okkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 8 MET A 252
SER A 389
VAL A 409
GLY A 243
 None
None
None
LLP  A 396 ( 3.6A)
 1.01A 4mk4A-2okkA:
4.1		 4mk4A-2okkA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 6 LEU A 407
ASN A 419
GLN A 445
LEU A 444
 None
 1.14A 4nc3A-2okkA:
undetectable		 4nc3A-2okkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 11 PHE A 344
GLY A 342
THR A 502
LEU A 475
SER A 374
 None
 1.36A 4or0A-2okkA:
0.7		 4or0A-2okkA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 LEU A 455
LEU A 408
GLY A 369
MET A 373
PHE A 467
 None
 1.48A 4pgfA-2okkA:
undetectable		 4pgfA-2okkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.79A 5a06A-2okkA:
undetectable		 5a06A-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.80A 5a06B-2okkA:
undetectable		 5a06B-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.78A 5a06C-2okkA:
3.2		 5a06C-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.79A 5a06E-2okkA:
undetectable		 5a06E-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.77A 5a06F-2okkA:
3.0		 5a06F-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 4 ASP A 305
HIS A 280
SER A 278
GLU A 279
 None
 1.19A 5hfjC-2okkA:
0.0		 5hfjC-2okkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 GLY A 235
ALA A 387
SER A 240
ILE A 238
PHE A 239
 None
 0.98A 5ih0A-2okkA:
undetectable		 5ih0A-2okkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 5 HIS A 395
ALA A 366
SER A 405
GLY A 242
 LLP  A 396 ( 4.1A)
LLP  A 396 ( 3.5A)
LLP  A 396 ( 4.9A)
LLP  A 396 ( 3.4A)
 1.19A 5yodD-2okkA:
undetectable		 5yodD-2okkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		3 / 3 LYS A 454
VAL A 400
ASP A 194
 None
 0.51A 6fgdA-2okkA:
2.2		 6fgdA-2okkA:
21.18