SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ola'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A 176
ARG A 178
LEU A 184
ALA A 188
ILE A 213
 None
 0.92A 1fk6A-2olaA:
undetectable		 1fk6A-2olaA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 PHE A  15
TYR A 275
PRO A  14
SER A  12
 None
 1.45A 1gyxA-2olaA:
0.0
1gyxB-2olaA:
0.0		 1gyxA-2olaA:
15.38
1gyxB-2olaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 LEU A 313
PRO A 297
LEU A 318
ARG A 317
 None
 1.44A 1hrkB-2olaA:
undetectable		 1hrkB-2olaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ILE A 152
PRO A 214
LEU A 184
VAL A 241
ASP A 219
 None
 1.45A 1mrlB-2olaA:
undetectable
1mrlC-2olaA:
undetectable		 1mrlB-2olaA:
20.58
1mrlC-2olaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A 184
LEU A 187
GLN A 191
LEU A 168
ARG A 160
 None
 1.14A 1zucB-2olaA:
undetectable		 1zucB-2olaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.35A 2eimJ-2olaA:
undetectable		 2eimJ-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.36A 2eimW-2olaA:
undetectable		 2eimW-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 PHE A  51
TYR A  56
THR A 282
ARG A 246
TYR A 301
 None
 1.40A 2qm9B-2olaA:
undetectable		 2qm9B-2olaA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 THR A 102
GLU A  47
PHE A  51
ILE A  61
 None
 1.23A 2w98B-2olaA:
undetectable		 2w98B-2olaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.34A 3ag1J-2olaA:
undetectable		 3ag1J-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A 184
LEU A 187
GLN A 191
LEU A 168
ARG A 160
 None
 1.09A 3d90B-2olaA:
undetectable		 3d90B-2olaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 VAL A 240
SER A 224
ALA A 256
LEU A 260
 None
 0.88A 3kk6B-2olaA:
undetectable		 3kk6B-2olaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ARG A  29
THR A  53
TRP A  55
 None
 1.20A 4d7hA-2olaA:
1.3		 4d7hA-2olaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLN A 155
ASP A 163
LEU A 146
PRO A 141
ILE A 144
 None
 1.40A 4kmuC-2olaA:
0.0		 4kmuC-2olaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 LEU A  36
VAL A  90
VAL A  67
ARG A 246
 None
 1.09A 4r7iA-2olaA:
undetectable		 4r7iA-2olaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ARG A  29
THR A  53
TRP A  55
 None
 1.16A 4ug5A-2olaA:
undetectable		 4ug5A-2olaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ARG A  29
THR A  53
TRP A  55
 None
 1.18A 4uglA-2olaA:
undetectable		 4uglA-2olaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ARG A  29
THR A  53
TRP A  55
 None
 1.18A 5g6cA-2olaA:
undetectable		 5g6cA-2olaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 0.99A 5igjA-2olaA:
undetectable		 5igjA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 0.97A 5igpA-2olaA:
undetectable		 5igpA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ILE A  34
VAL A 104
ALA A  85
ALA A  86
VAL A  90
 None
 1.00A 5igtA-2olaA:
undetectable		 5igtA-2olaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LYS A 243
LEU A 225
ILE A 257
 None
 0.82A 5kc4A-2olaA:
undetectable		 5kc4A-2olaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ILE A  34
VAL A  67
LEU A  36
PHE A   8
LEU A   3
 None
 1.31A 5tiwA-2olaA:
undetectable		 5tiwA-2olaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A 242
ILE A 269
GLY A 270
GLY A 271
VAL A 253
 None
 1.07A 5twjB-2olaA:
undetectable		 5twjB-2olaA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.26A 5w97J-2olaA:
undetectable		 5w97J-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.36A 5wauJ-2olaA:
undetectable		 5wauJ-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.38A 5x19J-2olaA:
undetectable		 5x19J-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.30A 5x1bW-2olaA:
undetectable		 5x1bW-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.30A 5x1fW-2olaA:
undetectable		 5x1fW-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		5 / 7 PHE A  51
ILE A  61
PHE A   8
LEU A  32
CYH A  31
 None
 1.16A 6b5vA-2olaA:
0.4
6b5vB-2olaA:
undetectable		 6b5vA-2olaA:
14.14
6b5vB-2olaA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.25A 6nknJ-2olaA:
undetectable		 6nknJ-2olaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 TYR A 280
MET A 284
THR A 282
LEU A 285
 None
 1.25A 6nknW-2olaA:
undetectable		 6nknW-2olaA:
13.70