SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ols'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A  34
HIS A 310
GLU A 308
GLY A 312
MET A 315
 None
 1.33A 1d4fD-2olsA:
undetectable		 1d4fD-2olsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 8 ALA A 738
GLY A 698
ILE A 677
ILE A 771
ILE A 739
 None
 1.16A 1hshD-2olsA:
undetectable		 1hshD-2olsA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 6 ALA A 107
LYS A 110
ASP A 114
ALA A 115
 None
 0.38A 1iwhA-2olsA:
undetectable		 1iwhA-2olsA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ILE A 739
LEU A 735
PHE A 762
GLY A 755
 None
 0.95A 1os6A-2olsA:
undetectable		 1os6A-2olsA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 GLY A 750
VAL A 749
GLU A 772
SER A 775
ILE A 701
 None
 1.24A 1pk9C-2olsA:
undetectable		 1pk9C-2olsA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ALA A 188
LEU A  92
HIS A 159
PHE A  55
PHE A  96
 None
 1.31A 1y0xX-2olsA:
undetectable		 1y0xX-2olsA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 GLY A 199
SER A 201
SER A 291
VAL A 282
ILE A 263
 None
 1.11A 2nnhA-2olsA:
undetectable		 2nnhA-2olsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 VAL A 633
ASN A 641
ILE A 516
MET A 513
VAL A 578
 None
 1.09A 2uxoB-2olsA:
undetectable		 2uxoB-2olsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 VAL A   6
ILE A 120
VAL A 122
GLY A  44
 None
 0.87A 3hjoB-2olsA:
undetectable		 3hjoB-2olsA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ARG A 321
VAL A 280
PRO A 283
ALA A 200
GLY A 199
 None
 0.96A 3ku1A-2olsA:
undetectable		 3ku1A-2olsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ARG A 321
ASP A 286
PRO A 283
ALA A 200
GLY A 199
 None
 0.77A 3ku1C-2olsA:
undetectable		 3ku1C-2olsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ARG A 321
VAL A 280
PRO A 283
ALA A 200
GLY A 199
 None
 0.88A 3ku1C-2olsA:
undetectable		 3ku1C-2olsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 ILE A 516
GLU A 514
THR A 576
LEU A 630
VAL A 564
 None
 1.15A 3n0hA-2olsA:
undetectable		 3n0hA-2olsA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 ASN A 685
ASP A 705
GLU A 587
SER A 684
 None
 1.25A 3p2kC-2olsA:
undetectable		 3p2kC-2olsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 HIS A 759
ARG A 727
GLU A 726
 None
 1.14A 3qf1A-2olsA:
undetectable		 3qf1A-2olsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 4 SER A 684
GLY A 610
GLU A 514
 None
 0.52A 3raeA-2olsA:
1.4
3raeC-2olsA:
undetectable		 3raeA-2olsA:
23.91
3raeC-2olsA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 1.03A 3rr3A-2olsA:
undetectable		 3rr3A-2olsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 1.02A 3rr3B-2olsA:
undetectable		 3rr3B-2olsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 1.02A 3rr3C-2olsA:
undetectable		 3rr3C-2olsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 1.02A 3rr3D-2olsA:
undetectable		 3rr3D-2olsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 ILE A 739
LEU A 735
PHE A 762
GLY A 755
 None
 1.03A 4hajA-2olsA:
undetectable		 4hajA-2olsA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ILE A 253
ILE A 292
PHE A 290
GLY A 548
 None
 0.79A 4hb6A-2olsA:
undetectable		 4hb6A-2olsA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ILE A 253
ILE A 292
PHE A 290
GLY A 548
 None
 0.82A 4hb8A-2olsA:
undetectable		 4hb8A-2olsA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 ILE A 739
LEU A 735
PHE A 762
GLY A 755
 None
 1.02A 4hbfA-2olsA:
undetectable		 4hbfA-2olsA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 ILE A 739
LEU A 735
PHE A 762
GLY A 755
 None
 0.91A 4hc3A-2olsA:
undetectable		 4hc3A-2olsA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ILE A 253
ILE A 292
PHE A 290
GLY A 548
 None
 0.83A 4hdlA-2olsA:
undetectable		 4hdlA-2olsA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 ASP A 316
LEU A 207
VAL A 241
 None
 0.55A 4jecB-2olsA:
undetectable		 4jecB-2olsA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 TYR A 614
VAL A 649
LEU A 662
LEU A 676
 None
 1.09A 4jtrA-2olsA:
9.2		 4jtrA-2olsA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 4 SER A 684
GLY A 610
GLU A 514
 None
 0.46A 4juoA-2olsA:
undetectable
4juoC-2olsA:
undetectable		 4juoA-2olsA:
23.91
4juoC-2olsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 SER A 121
MET A 265
LEU A 225
PHE A 267
 None
 1.31A 5evyX-2olsA:
0.0		 5evyX-2olsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ALA A  46
ALA A 188
VAL A 124
GLY A  21
THR A 129
 None
 1.07A 5igjA-2olsA:
undetectable		 5igjA-2olsA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 0.97A 5jvzA-2olsA:
0.3		 5jvzA-2olsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 1.06A 5jw1A-2olsA:
undetectable		 5jw1A-2olsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 4 LEU A 591
ARG A 613
ILE A 517
PHE A 583
 None
 1.15A 5kirB-2olsA:
undetectable		 5kirB-2olsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 THR A 414
ALA A 434
ALA A 365
GLY A 417
GLY A 418
 None
 0.86A 5lf3K-2olsA:
undetectable
5lf3L-2olsA:
undetectable		 5lf3K-2olsA:
14.85
5lf3L-2olsA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 THR A 414
ALA A 434
ALA A 365
GLY A 417
GLY A 418
 None
 0.87A 5lf3Y-2olsA:
undetectable
5lf3Z-2olsA:
undetectable		 5lf3Y-2olsA:
14.85
5lf3Z-2olsA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 THR A 414
ALA A 434
ALA A 365
GLY A 417
GLY A 418
 None
 0.79A 5lf7K-2olsA:
undetectable
5lf7L-2olsA:
undetectable		 5lf7K-2olsA:
14.85
5lf7L-2olsA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 THR A 414
ALA A 434
ALA A 365
GLY A 417
GLY A 418
 None
 0.79A 5lf7Y-2olsA:
undetectable
5lf7Z-2olsA:
undetectable		 5lf7Y-2olsA:
14.85
5lf7Z-2olsA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ILE A 516
PRO A 647
GLU A 681
LEU A 510
GLU A 626
 None
 1.42A 5mqtC-2olsA:
undetectable		 5mqtC-2olsA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 LEU A 328
VAL A  39
GLU A 295
ALA A 252
ALA A 301
 None
 1.11A 5n5dB-2olsA:
2.2		 5n5dB-2olsA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 10 VAL A 241
ILE A 292
LEU A 300
THR A 298
ALA A 301
 None
 1.04A 5vm8B-2olsA:
undetectable		 5vm8B-2olsA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 ALA A 568
GLY A 507
ASP A 635
LEU A 667
LEU A 674
 None
 1.15A 5wwsA-2olsA:
undetectable		 5wwsA-2olsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 MET A 679
ASP A 582
ARG A 715
 None
 1.21A 5z6kA-2olsA:
undetectable		 5z6kA-2olsA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 TYR A 588
ALA A 527
LEU A 528
 None
 0.58A 6ag0C-2olsA:
9.5		 6ag0C-2olsA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 GLY A 753
GLN A 754
SER A 703
PHE A 724
 None
 1.17A 6eqpA-2olsA:
undetectable		 6eqpA-2olsA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 THR A 414
ALA A 434
ALA A 365
GLY A 417
GLY A 418
 None
 0.86A 6hwdK-2olsA:
undetectable
6hwdL-2olsA:
undetectable		 6hwdK-2olsA:
7.22
6hwdL-2olsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ols PHOSPHOENOLPYRUVATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 11 THR A 414
ALA A 434
ALA A 365
GLY A 417
GLY A 418
 None
 0.86A 6hwdY-2olsA:
undetectable
6hwdZ-2olsA:
undetectable		 6hwdY-2olsA:
7.22
6hwdZ-2olsA:
7.59