SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2olw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 6 VAL A 187
GLY A 188
ALA A 121
LEU A 125
 None
 0.64A 1e7bB-2olwA:
undetectable		 1e7bB-2olwA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 7 SER A  82
ASP A  81
VAL A 111
LEU A 131
 None
None
None
ACY  A1004 (-3.8A)
 1.03A 2hdnE-2olwA:
undetectable
2hdnF-2olwA:
undetectable
2hdnH-2olwA:
undetectable		 2hdnE-2olwA:
11.83
2hdnF-2olwA:
21.11
2hdnH-2olwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 6 GLU A  65
LYS A  46
PHE A  66
PRO A  47
 None
 1.43A 2vmyA-2olwA:
undetectable		 2vmyA-2olwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 8 SER A 203
ASP A 205
VAL A 215
ARG A 213
 None
ACY  A1005 ( 4.7A)
None
None
 1.14A 4lnwA-2olwA:
undetectable		 4lnwA-2olwA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 6 GLY A  76
ASP A  81
ILE A 195
TYR A 109
 None
 1.14A 5iwuA-2olwA:
undetectable		 5iwuA-2olwA:
20.66