SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2om6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 195
GLY A 196
GLY A 191
PHE A 164
VAL A   7
 None
 1.08A 1fduC-2om6A:
3.6		 1fduC-2om6A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 179
LEU A 108
LEU A 116
ILE A 145
 None
 0.99A 1z95A-2om6A:
undetectable		 1z95A-2om6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 136
ILE A 145
HIS A 180
ASP A 188
GLY A 182
 None
 1.19A 1zz1B-2om6A:
undetectable
1zz1C-2om6A:
undetectable		 1zz1B-2om6A:
21.93
1zz1C-2om6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A  15
THR A 104
THR A   8
HIS A 180
 None
 1.01A 2zj0B-2om6A:
3.5		 2zj0B-2om6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A  48
ILE A  51
LEU A  66
THR A 132
 SO4  A1300 (-2.5A)
None
None
None
 1.23A 3nxuA-2om6A:
undetectable		 3nxuA-2om6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 103
THR A 104
LEU A 101
GLU A 106
 None
 1.00A 3ps9A-2om6A:
undetectable		 3ps9A-2om6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 8 GLU A  60
GLU A 153
ASN A 123
GLY A 122
 None
 0.73A 4f93B-2om6A:
undetectable		 4f93B-2om6A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A  10
ASP A 188
ALA A 186
ASP A 183
 SO4  A1300 ( 4.9A)
None
None
None
 1.20A 4mdaA-2om6A:
undetectable		 4mdaA-2om6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  65
PHE A 126
ARG A  48
 None
None
SO4  A1300 (-2.5A)
 0.64A 4xr4B-2om6A:
5.1		 4xr4B-2om6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 155
ASP A  61
PRO A  62
ARG A  63
 None
 1.17A 6fgdA-2om6A:
2.1		 6fgdA-2om6A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE
(Pyrococcus
horikoshii) 		3 / 3 TRP A 198
GLU A 176
GLU A 214
 None
 0.85A 6fhwA-2om6A:
undetectable		 6fhwA-2om6A:
16.31