SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ome'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A  87
GLY A 105
ILE A 104
VAL A 111
 None
 0.69A 1d4sB-2omeA:
undetectable		 1d4sB-2omeA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE A 345
VAL A  36
GLY A  78
ALA A  55
LEU A  51
 None
 1.05A 1e7bA-2omeA:
undetectable		 1e7bA-2omeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A 240
VAL A 206
LEU A 183
 None
 0.74A 1yajG-2omeA:
undetectable		 1yajG-2omeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 229
LEU A 232
LEU A 183
LEU A 241
THR A 257
 None
 1.14A 1zucB-2omeA:
undetectable		 1zucB-2omeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ARG A 198
LEU A 145
VAL A 268
VAL A 195
 None
 0.95A 2bdmA-2omeA:
undetectable		 2bdmA-2omeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 VAL A  36
GLY A  78
ALA A  55
LEU A  51
ARG A 342
 None
 1.23A 2bxgA-2omeA:
undetectable		 2bxgA-2omeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASP A 237
PHE A 266
ALA A 176
ARG A 291
 None
 1.23A 2e5dA-2omeA:
undetectable
2e5dB-2omeA:
undetectable		 2e5dA-2omeA:
22.27
2e5dB-2omeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE A 101
ILE A 121
ALA A  97
LEU A  98
LEU A  87
 None
 1.06A 3ozvB-2omeA:
2.8		 3ozvB-2omeA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLY A 273
GLY A 274
ASN A 249
GLU A 301
 None
None
NAD  A 901 (-4.2A)
None
 0.72A 4fgkB-2omeA:
4.8		 4fgkB-2omeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A 330
MET A 333
ASP A 136
 None
 0.91A 4mm4B-2omeA:
undetectable		 4mm4B-2omeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 ALA A  79
ASP A 112
GLY A 117
GLU A 360
 None
 0.95A 5bs8A-2omeA:
undetectable
5bs8B-2omeA:
undetectable
5bs8C-2omeA:
undetectable		 5bs8A-2omeA:
22.51
5bs8B-2omeA:
23.16
5bs8C-2omeA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 THR A 138
ALA A 135
THR A 134
HIS A 242
 None
None
NAD  A 901 (-3.4A)
None
 0.99A 5ecoA-2omeA:
2.7		 5ecoA-2omeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG A 190
PRO A 127
ASN A 355
 NAD  A 901 (-4.0A)
None
None
 1.08A 5jwaA-2omeA:
4.1
5jwaH-2omeA:
4.5		 5jwaA-2omeA:
19.10
5jwaH-2omeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 290
ASP A 277
LEU A 145
PHE A 305
GLY A 308
 None
 1.01A 5uxdB-2omeA:
undetectable		 5uxdB-2omeA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 GLY A 292
ARG A 148
ASN A 315
LEU A 145
 None
 1.45A 6b58A-2omeA:
undetectable		 6b58A-2omeA:
20.94