SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2omj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IEP_A_STIA201_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	4 / 6	VAL A 32 VAL A 60 ILE A 72 ARG A 9	None	1.06A	1iepA-2omjA: undetectable	1iepA-2omjA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKV_A_478A200_1 (PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 10	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.85A	3ekvA-2omjA: undetectable	3ekvA-2omjA: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM3_B_478B200_1 (PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 10	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.92A	3em3A-2omjA: undetectable	3em3A-2omjA: 25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NUO_B_478B478_2 (PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 9	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.92A	3nuoB-2omjA: undetectable	3nuoB-2omjA: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_B_478B200_1 (HIV-1 PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 9	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.95A	3oxvA-2omjA: undetectable	3oxvA-2omjA: 25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_C_478C200_1 (HIV-1 PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 9	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.88A	3oxvC-2omjA: undetectable	3oxvC-2omjA: 25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVJ_B_478B101_2 (HIV-1 PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 9	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.84A	4rvjB-2omjA: undetectable	4rvjB-2omjA: 27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVJ_D_478D101_2 (HIV-1 PROTEASE)	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	5 / 9	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.84A	4rvjD-2omjA: undetectable	4rvjD-2omjA: 27.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IEP_A_STIA201_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",4,"VAL A  32;VAL A  60;ILE A  72;ARG A   9","None","1.06A","1iepA-2omjA:undetectable","1iepA-2omjA:14.97"],["3EKV_A_478A200_1","PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.85A","3ekvA-2omjA:undetectable","3ekvA-2omjA:24.53"],["3EM3_B_478B200_1","PROTEASE;PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.92A","3em3A-2omjA:undetectable","3em3A-2omjA:25.47"],["3NUO_B_478B478_2","PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.92A","3nuoB-2omjA:undetectable","3nuoB-2omjA:22.64"],["3OXV_B_478B200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.95A","3oxvA-2omjA:undetectable","3oxvA-2omjA:25.47"],["3OXV_C_478C200_1","HIV-1 PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.88A","3oxvC-2omjA:undetectable","3oxvC-2omjA:25.47"],["4RVJ_B_478B101_2","HIV-1 PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.84A","4rvjB-2omjA:undetectable","4rvjB-2omjA:27.52"],["4RVJ_D_478D101_2","HIV-1 PROTEASE","2omj","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","Homo sapiens",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.84A","4rvjD-2omjA:undetectable","4rvjD-2omjA:27.52"]]