SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2omk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2omk HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 8 LEU A 170
ALA A 188
LEU A 205
GLY A -10
ASP A -12
 None
 1.49A 2yfxA-2omkA:
undetectable		 2yfxA-2omkA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2omk HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A  47
HIS A  49
SER A  46
 None
 0.92A 4mjwA-2omkA:
undetectable
4mjwB-2omkA:
undetectable		 4mjwA-2omkA:
17.47
4mjwB-2omkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2omk HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A  46
ARG A  47
HIS A  49
 None
 0.90A 4mjwA-2omkA:
undetectable
4mjwB-2omkA:
undetectable		 4mjwA-2omkA:
17.47
4mjwB-2omkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2omk HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 4 ASN A  15
ILE A  99
TYR A 122
PHE A 138
 SNN  A  38 ( 3.4A)
None
None
None
 1.32A 5igvA-2omkA:
undetectable		 5igvA-2omkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2omk HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLY A  56
GLN A  75
LYS A  86
 None
 0.96A 5imsB-2omkA:
2.8		 5imsB-2omkA:
17.59