SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 6 VAL A 187
GLY A 188
ALA A 121
LEU A 125
 None
 0.64A 1e7bB-2omlA:
undetectable		 1e7bB-2omlA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 8 ALA A  93
GLY A  92
ARG A  97
THR A  89
 None
 0.88A 3rglA-2omlA:
undetectable		 3rglA-2omlA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 8 ARG A 153
TYR A  48
GLU A 114
ARG A 178
 SO4  A1428 (-3.1A)
SO4  A1428 (-4.6A)
None
None
 1.39A 4kr4C-2omlA:
undetectable		 4kr4C-2omlA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 8 GLU A 146
ILE A 157
GLN A 112
LEU A 194
 None
 0.76A 4mj8A-2omlA:
undetectable		 4mj8A-2omlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		3 / 3 ASN A  91
ALA A  93
ARG A  97
 None
 0.71A 5cvtB-2omlA:
undetectable		 5cvtB-2omlA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 6 GLY A  76
ASP A  81
ILE A 195
TYR A 109
 None
SO4  A1428 ( 4.9A)
None
SO4  A1424 (-4.3A)
 1.08A 5iwuA-2omlA:
undetectable		 5iwuA-2omlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		5 / 12 ILE A  67
LEU A 204
ASN A  45
LEU A  98
LEU A  88
 None
 1.29A 5xxiA-2omlA:
undetectable		 5xxiA-2omlA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E
(Escherichia
coli) 		4 / 8 ILE A 195
GLN A 112
THR A 165
GLU A 114
 None
 1.15A 6fbvC-2omlA:
undetectable		 6fbvC-2omlA:
10.19